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    PF3D7_0523000 multidrug resistance protein 1 [ Plasmodium falciparum 3D7 ]

    Gene ID: 813045, updated on 23-Nov-2023

    Summary

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    Gene symbol
    PF3D7_0523000
    Gene description
    multidrug resistance protein 1
    Locus tag
    PF3D7_0523000
    Gene type
    protein coding
    RNA name
    multidrug resistance protein 1
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_004326.2 (957890..962149)

    Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene pre-mRNA-splicing factor BUD31, putative Neighboring gene zinc finger protein, putative Neighboring gene mitochondrial-processing peptidase subunit alpha, putative Neighboring gene heptatricopeptide repeat-containing protein, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004326.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport. Calçada C, et al. mBio, 2020 Dec 1. PMID 33262257, Free PMC Article
    2. Spatio-temporal distribution of PfMDR1 polymorphism among uncomplicated Plasmodium falciparum malaria cases along international border of north east India. Goomber S, et al. Infect Genet Evol, 2018 Sep. PMID 29842979
    3. pfmdr1 (Plasmodium falciparum multidrug drug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies. Gil JP, et al. Expert Rev Anti Infect Ther, 2017 Jun. PMID 28355493
    4. Influence of the pfmdr1 Gene on In Vitro Sensitivities of Piperaquine in Thai Isolates of Plasmodium falciparum. Mungthin M, et al. Am J Trop Med Hyg, 2017 Mar. PMID 28044042, Free PMC Article
    5. Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1. Sonoiki E, et al. Antimicrob Agents Chemother, 2017 Jan. PMID 27821443, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea.
      Title: Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea.
    2. Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport.
      Title: Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport.
    3. Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China.
      Title: Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China.
    4. Selection of pfcrt K76 and pfmdr1 N86 Coding Alleles after Uncomplicated Malaria Treatment by Artemether-Lumefantrine in Mali.
      Title: Selection of pfcrt K76 and pfmdr1 N86 Coding Alleles after Uncomplicated Malaria Treatment by Artemether-Lumefantrine in Mali.
    5. Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria.
      Title: Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria.
    6. Spatio-temporal screening of Plasmodium population with PfMDR1 single nucleotide polymorphism accounts for its association with antimalarial susceptibility.
      Title: Spatio-temporal distribution of PfMDR1 polymorphism among uncomplicated Plasmodium falciparum malaria cases along international border of north east India.
    7. N86Y mutation augments resistance to the artemisinin-based combination therapy partner drug amodiaquine and the former first-line agent chloroquine; N86Y increases parasite susceptibility to the partner drugs lumefantrine and mefloquine, and the active artemisinin metabolite dihydroartemisinin
      Title: Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.
    8. Pfmdr1 is a pivotal factor in malaria resistance to artemisinin combination therapies. (Review)
      Title: pfmdr1 (Plasmodium falciparum multidrug drug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies.
    9. Altered Plasmodium falciparum sensitivity to the antiretroviral protease inhibitor lopinavir associated with polymorphisms in PfMDR1.
      Title: Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1.
    10. No significant association between the pfmdr1 copy number and piperaquine IC50 values was found. In contrast, the parasites containing the pfmdr1 86Y allele exhibited significantly reduced piperaquine sensitivity.
      Title: Influence of the pfmdr1 Gene on In Vitro Sensitivities of Piperaquine in Thai Isolates of Plasmodium falciparum.
    Submit: New GeneRIF Correction See all GeneRIFs (59)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables ATPase-coupled transmembrane transporter activity ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in food vacuole HDA PubMed 
    located_in food vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    multidrug resistance protein 1
    XP_001351787.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004326.2 Reference assembly

      Range
      957890..962149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351751.1 → XP_001351787.1  multidrug resistance protein 1 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351787.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P13568
      UniProtKB/TrEMBL
      A0A0L1IG68, A0A0L7M770, D5L5S6, F1C8M9, Q7K6A5, W7JYG0
      Conserved Domains (1) summary
      PTZ00265
      Location:1 → 1419
      PTZ00265; multidrug resistance protein (mdr1); Provisional
    Nucleotide Protein
    Heading Accession and Version

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