U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 [ Gallus gallus (chicken) ]

    Gene ID: 419070, updated on 3-Apr-2024

    Summary

    Go to the top of the page Help
    Symbol
    GDPD5provided by CGNC
    Full Name
    glycerophosphodiester phosphodiesterase domain containing 5provided by CGNC
    Primary source
    CGNC:50910
    See related
    Ensembl:ENSGALG00010002946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    GDE2
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (195409382..195567671)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (195276289..195434439)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101751623 Neighboring gene serpin family H member 1 Neighboring gene uncharacterized LOC121109258 Neighboring gene kelch like family member 35 Neighboring gene microtubule associated protein 6

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. GDP-bound Galphai2 regulates spinal motor neuron differentiation through interaction with GDE2. Periz G, et al. Dev Biol, 2010 May 1. PMID 20197066, Free PMC Article
    2. Transmembrane protein GDE2 induces motor neuron differentiation in vivo. Rao M, et al. Science, 2005 Sep 30. PMID 16195461
    3. GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Park S, et al. Science, 2013 Jan 18. PMID 23329048, Free PMC Article
    4. Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Yan Y, et al. Nat Commun, 2015 May 6. PMID 25943695, Free PMC Article
    5. The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2. Yan Y, et al. Cell, 2009 Sep 18. PMID 19766572, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prdx4 dimers generated by hydrogen peroxide metabolism oxidize two cysteine residues within the GDE2 enzymatic domain, which blocks GDE2 trafficking to the plasma membrane and prevents GDE2 neurogeneic function.
      Title: Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2.
    2. This study identifies a previously unrecognized mechanism to initiate neurogenesis that involves GDE2-mediated surface cleavage of GPI-anchored targets to inhibit Dll1-Notch signaling.
      Title: GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK.
    3. Study shows that Galphai2 function is mediated in part by its interaction with GDE2, a known regulator of motor neuron differentiation, and that disruption of the GDE2/Galphai2 complex in vivo causes motor neuron deficits analogous to Galphai2 ablation.
      Title: GDP-bound Galphai2 regulates spinal motor neuron differentiation through interaction with GDE2.
    4. Study identified the antioxidant enzyme Prdx1 as an interactor of GDE2 and uncover a developmental role for Prdx1 in regulating neuronal differentiation in the spinal cord.
      Title: The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2.
    5. a retinoid-inducible gene, GDE2 (glycerophosphodiester phosphodiesterase 2), encoding a six-transmembrane protein that is necessary and sufficient to drive spinal motor neuron differentiation in vivo was identified
      Title: Transmembrane protein GDE2 induces motor neuron differentiation in vivo.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glycerophosphodiester phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    glycerophosphodiester phosphodiesterase domain-containing protein 5
    Names
    glycerophosphocholine phosphodiesterase GDPD5
    glycerophosphodiester phosphodiesterase 2
    phosphoinositide phospholipase C GDPD5
    NP_001292079.1
    XP_015136462.1
    XP_015136464.1
    XP_040556487.1
    XP_040556494.1
    XP_046764341.1
    XP_046764342.1
    XP_046764343.1
    XP_046764344.1
    XP_046764345.1
    XP_046764346.1
    XP_046798199.1
    XP_046798208.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305150.2 → NP_001292079.1  glycerophosphodiester phosphodiesterase domain-containing protein 5

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000032
      UniProtKB/Swiss-Prot
      Q3KTM2
      Related
      ENSGALP00010004193.1, ENSGALT00010006876.1
      Conserved Domains (1) summary
      cd08608
      Location:227 → 576
      GDPD_GDE2; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE2 and similar proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      195409382..195567671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015280976.4 → XP_015136462.1  glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3KTM2
      UniProtKB/TrEMBL
      A0A1D5NU41
      Related
      ENSGALP00010004186.1, ENSGALT00010006867.1
      Conserved Domains (2) summary
      cd08608
      Location:227 → 581
      GDPD_GDE2; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE2 and similar proteins
      COG0584
      Location:227 → 484
      UgpQ; Glycerophosphoryl diester phosphodiesterase [Lipid transport and metabolism]

    2. XM_040700553.2 → XP_040556487.1  glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X2

      UniProtKB/Swiss-Prot
      Q3KTM2
      Related
      ENSGALP00010004180.1, ENSGALT00010006860.1
      Conserved Domains (1) summary
      cd08608
      Location:227 → 576
      GDPD_GDE2; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE2 and similar proteins

    3. XM_046942252.1 → XP_046798208.1  glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X4

      UniProtKB/TrEMBL
      A0A1D5P988
      Related
      ENSGALP00010004200.1, ENSGALT00010006885.1

    4. XM_046942243.1 → XP_046798199.1  glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X3

      UniProtKB/TrEMBL
      A0A8V0X7U9
      Related
      ENSGALP00010004183.1, ENSGALT00010006863.1

    5. XM_015280978.4 → XP_015136464.1  glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3KTM2
      UniProtKB/TrEMBL
      A0A1D5NU41
      Conserved Domains (2) summary
      cd08608
      Location:227 → 581
      GDPD_GDE2; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE2 and similar proteins
      COG0584
      Location:227 → 484
      UgpQ; Glycerophosphoryl diester phosphodiesterase [Lipid transport and metabolism]

    6. XM_040700560.2 → XP_040556494.1  glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X2

      UniProtKB/Swiss-Prot
      Q3KTM2
      Conserved Domains (1) summary
      cd08608
      Location:227 → 576
      GDPD_GDE2; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE2 and similar proteins

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      195276289..195434439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046908385.1 → XP_046764341.1  glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1

    2. XM_046908387.1 → XP_046764343.1  glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X2

    3. XM_046908390.1 → XP_046764346.1  glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X4

    4. XM_046908389.1 → XP_046764345.1  glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X3

    5. XM_046908386.1 → XP_046764342.1  glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1

    6. XM_046908388.1 → XP_046764344.1  glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037271.1: Suppressed sequence

      Description
      NM_001037271.1: This RefSeq was temporarily suppressed because it had an insertion compared to the reference sequence and an exon with a non-consensus splice site. Correction of these differences results in premature translation termination.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KTM2.1 GenPept UniProtKB/Swiss-Prot:Q3KTM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous