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    PACRG parkin coregulated [ Homo sapiens (human) ]

    Gene ID: 135138, updated on 7-May-2017
    Official Symbol
    PACRGprovided by HGNC
    Official Full Name
    parkin coregulatedprovided by HGNC
    Primary source
    HGNC:HGNC:19152
    See related
    Ensembl:ENSG00000112530 MIM:608427; Vega:OTTHUMG00000016116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLUP; PARK2CRG; HAK005771
    Summary
    This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    6q26
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (162726870..163315492)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (163148164..163736524)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene parkin RBR E3 ubiquitin protein ligase Neighboring gene uncharacterized LOC105369171 Neighboring gene keratin 8 pseudogene 44 Neighboring gene transfer RNA-Glu (TTC) 15-1 Neighboring gene ribosomal protein L34 pseudogene 15 Neighboring gene PACRG antisense RNA 2 Neighboring gene uncharacterized LOC105378095 Neighboring gene PACRG antisense RNA 3 Neighboring gene uncharacterized LOC401282 Neighboring gene PACRG antisense RNA 1 Neighboring gene ribosomal protein L37a pseudogene 4

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ32724

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Hsp70 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to unfolded protein TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatid development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell body IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sperm midpiece IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    parkin coregulated gene protein
    Names
    PARK2 co-regulated
    PARK2 coregulated
    molecular chaperone/chaperonin-binding protein
    parkin co-regulated gene protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011525.1 RefSeqGene

      Range
      5001..593361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001080378.1NP_001073847.1  parkin coregulated gene protein isoform 2

      See identical proteins and their annotated locations for NP_001073847.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AP001576, BC044227
      Consensus CDS
      CCDS43524.1
      UniProtKB/Swiss-Prot
      Q96M98
      Related
      ENSP00000355855.2, OTTHUMP00000017729, ENST00000366889.6, OTTHUMT00000043332
      Conserved Domains (1) summary
      pfam10274
      Location:70253
      ParcG; Parkin co-regulated protein
    2. NM_001080379.1NP_001073848.1  parkin coregulated gene protein isoform 2

      See identical proteins and their annotated locations for NP_001073848.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon at its 5' end and an in-frame internal exon, compared to variant 1. These differences produce a unique 5' UTR and a protein (isoform 2) that is shorter than isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AF546872, BC044227
      Consensus CDS
      CCDS43524.1
      UniProtKB/Swiss-Prot
      Q96M98
      Related
      ENSP00000355854.2, OTTHUMP00000017730, ENST00000366888.6, OTTHUMT00000043333
      Conserved Domains (1) summary
      pfam10274
      Location:70253
      ParcG; Parkin co-regulated protein
    3. NM_152410.2NP_689623.2  parkin coregulated gene protein isoform 1

      See identical proteins and their annotated locations for NP_689623.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK057286, AL354942, BC044227
      Consensus CDS
      CCDS5284.1
      UniProtKB/Swiss-Prot
      Q96M98
      Related
      ENSP00000337946.3, OTTHUMP00000239114, ENST00000337019.7, OTTHUMT00000400424
      Conserved Domains (1) summary
      pfam10274
      Location:70292
      ParcG; Parkin co-regulated protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      162726870..163315492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010277.1XP_016865766.1  parkin coregulated gene protein isoform X1

    2. XM_017010275.1XP_016865764.1  parkin coregulated gene protein isoform X1

    3. XM_017010279.1XP_016865768.1  parkin coregulated gene protein isoform X1

    4. XM_017010278.1XP_016865767.1  parkin coregulated gene protein isoform X1

    5. XM_011535461.2XP_011533763.1  parkin coregulated gene protein isoform X2

      Conserved Domains (1) summary
      pfam10274
      Location:70227
      ParcG; Parkin co-regulated protein
    6. XM_011535462.2XP_011533764.1  parkin coregulated gene protein isoform X3

      Conserved Domains (1) summary
      pfam10274
      Location:70205
      ParcG; Parkin co-regulated protein
    7. XM_011535468.2XP_011533770.1  parkin coregulated gene protein isoform X11

      Conserved Domains (1) summary
      pfam10274
      Location:70204
      ParcG; Parkin co-regulated protein
    8. XM_006715344.3XP_006715407.1  parkin coregulated gene protein isoform X5

      Conserved Domains (1) summary
      pfam10274
      Location:70204
      ParcG; Parkin co-regulated protein
    9. XM_006715345.3XP_006715408.1  parkin coregulated gene protein isoform X9

      Conserved Domains (1) summary
      pfam10274
      Location:70204
      ParcG; Parkin co-regulated protein
    10. XM_011535469.2XP_011533771.1  parkin coregulated gene protein isoform X12

      Conserved Domains (1) summary
      pfam10274
      Location:70204
      ParcG; Parkin co-regulated protein
    11. XM_005266826.4XP_005266883.1  parkin coregulated gene protein isoform X10

      Conserved Domains (1) summary
      pfam10274
      Location:70204
      ParcG; Parkin co-regulated protein
    12. XM_005266825.4XP_005266882.1  parkin coregulated gene protein isoform X7

      Conserved Domains (1) summary
      pfam10274
      Location:70204
      ParcG; Parkin co-regulated protein
    13. XM_017010276.1XP_016865765.1  parkin coregulated gene protein isoform X1

    14. XM_017010280.1XP_016865769.1  parkin coregulated gene protein isoform X4

    15. XM_011535466.1XP_011533768.1  parkin coregulated gene protein isoform X8

      Conserved Domains (1) summary
      pfam10274
      Location:70204
      ParcG; Parkin co-regulated protein
    16. XM_011535471.1XP_011533773.1  parkin coregulated gene protein isoform X13

      Conserved Domains (1) summary
      pfam10274
      Location:7097
      ParcG; Parkin co-regulated protein
    17. XM_017010281.1XP_016865770.1  parkin coregulated gene protein isoform X6

    18. XM_017010282.1XP_016865771.1  parkin coregulated gene protein isoform X6

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      163410401..163998862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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