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    Npepl1 aminopeptidase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 228961, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Npepl1provided by MGI
    Official Full Name
    aminopeptidase-like 1provided by MGI
    Primary source
    MGI:MGI:2448523
    See related
    Ensembl:ENSMUSG00000039263 AllianceGenome:MGI:2448523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1974
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in protein metabolic process. Predicted to be active in cytoplasm. Orthologous to human NPEPL1 (aminopeptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 80.4), adrenal adult (RPKM 69.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H4; 2 97.87 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173951904..173964495)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (174110338..174122702)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 7, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7892 Neighboring gene syntaxin 16 Neighboring gene predicted gene 10714 Neighboring gene STARR-seq mESC enhancer starr_06632 Neighboring gene microRNA 296

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable aminopeptidase NPEPL1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378793.1 → NP_001365722.1  probable aminopeptidase NPEPL1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL669896
      UniProtKB/TrEMBL
      Q3TCV9, Q3U199, Q3UD03
      Conserved Domains (1) summary
      cd00433
      Location:35 → 492
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

    2. NM_213733.2 → NP_998898.1  probable aminopeptidase NPEPL1 isoform 2

      See identical proteins and their annotated locations for NP_998898.1

      Status: VALIDATED

      Source sequence(s)
      AK150313, BU148687, BX517579
      Consensus CDS
      CCDS17148.1
      UniProtKB/Swiss-Prot
      A2ACM6, Q66JY0, Q6NSR8
      UniProtKB/TrEMBL
      Q3TCV9, Q3U199, Q3UD03
      Related
      ENSMUSP00000042808.10, ENSMUST00000044415.16
      Conserved Domains (1) summary
      cd00433
      Location:35 → 487
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      173951904..173964495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_374463.2 RNA Sequence

    2. XR_374462.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NSR8.1 GenPept UniProtKB/Swiss-Prot:Q6NSR8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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