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    EFL1 elongation factor like GTPase 1 [ Homo sapiens (human) ]

    Gene ID: 79631, updated on 9-May-2017
    Official Symbol
    EFL1provided by HGNC
    Official Full Name
    elongation factor like GTPase 1provided by HGNC
    Primary source
    HGNC:HGNC:25789
    See related
    Ensembl:ENSG00000140598 Vega:OTTHUMG00000172573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RIA1; EFTUD1; FAM42A; HsT19294
    Orthologs
    Location:
    15q25.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (82130220..82262763, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (82422561..82555104, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mex-3 RNA binding family member B Neighboring gene uncharacterized LOC105370924 Neighboring gene long intergenic non-protein coding RNA 1583 Neighboring gene RNA, U1 small nuclear 77, pseudogene Neighboring gene stabilizer of axonemal microtubules 2 Neighboring gene ADAMTS7 pseudogene 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of elongation factor Tu GTP binding domain containing 1 (EFTUD1) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ13119

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribosome binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    mature ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translational elongation IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    elongation factor-like GTPase 1
    Names
    elongation factor Tu GTP binding domain containing 1
    elongation factor Tu GTP-binding domain-containing protein 1
    elongation factor-like 1
    ribosome assembly 1 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040610.2NP_001035700.1  elongation factor-like GTPase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the 5' coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC026624, AC026956, BC014628
      Consensus CDS
      CCDS42070.1
      UniProtKB/Swiss-Prot
      Q7Z2Z2
      Related
      ENSP00000352418.3, OTTHUMP00000248769, ENST00000359445.7, OTTHUMT00000419253
      Conserved Domains (6) summary
      cd01681
      Location:636935
      aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
      cd04096
      Location:9321010
      eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
      PTZ00416
      Location:11052
      PTZ00416; elongation factor 2; Provisional
      cd16268
      Location:451549
      EF2_II; Domain II of Elongation Factor 2
      cd16261
      Location:565636
      EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)
      cl21455
      Location:20202
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001322844.1NP_001309773.1  elongation factor-like GTPase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC026624, AC026956
      Conserved Domains (4) summary
      cd01681
      Location:424723
      aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
      cd04096
      Location:720798
      eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
      cd16268
      Location:239337
      EF2_II; Domain II of Elongation Factor 2
      cd16261
      Location:353424
      EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)
    3. NM_001322845.1NP_001309774.1  elongation factor-like GTPase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC026624, AC026956
      Consensus CDS
      CCDS42071.1
      UniProtKB/Swiss-Prot
      Q7Z2Z2
      Conserved Domains (6) summary
      cd01885
      Location:20253
      EF2; Elongation Factor 2 (EF2) in archaea and eukarya
      cd01681
      Location:687986
      aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
      cd04096
      Location:9831061
      eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
      PTZ00416
      Location:11103
      PTZ00416; elongation factor 2; Provisional
      cd16268
      Location:502600
      EF2_II; Domain II of Elongation Factor 2
      cd16261
      Location:616687
      EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)
    4. NM_024580.5NP_078856.4  elongation factor-like GTPase 1 isoform 1

      See identical proteins and their annotated locations for NP_078856.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the the longest isoform (1).
      Source sequence(s)
      AC026624, AC026956, BC014628
      Consensus CDS
      CCDS42071.1
      UniProtKB/Swiss-Prot
      Q7Z2Z2
      Related
      ENSP00000268206.7, OTTHUMP00000248768, ENST00000268206.11, OTTHUMT00000419252
      Conserved Domains (6) summary
      cd01885
      Location:20253
      EF2; Elongation Factor 2 (EF2) in archaea and eukarya
      cd01681
      Location:687986
      aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
      cd04096
      Location:9831061
      eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
      PTZ00416
      Location:11103
      PTZ00416; elongation factor 2; Provisional
      cd16268
      Location:502600
      EF2_II; Domain II of Elongation Factor 2
      cd16261
      Location:616687
      EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)

    RNA

    1. NR_136410.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC026624, AC026956

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      82130220..82262763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522000.1XP_011520302.1  elongation factor-like GTPase 1 isoform X1

      See identical proteins and their annotated locations for XP_011520302.1

      Conserved Domains (4) summary
      cd01681
      Location:424723
      aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
      cd04096
      Location:720798
      eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
      cd16268
      Location:239337
      EF2_II; Domain II of Elongation Factor 2
      cd16261
      Location:353424
      EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      82540549..82673133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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