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Apoe apolipoprotein E [ Rattus norvegicus (Norway rat) ]

Gene ID: 25728, updated on 11-Apr-2024

Summary

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Official Symbol: Apoeprovided by RGD
Official Full Name: apolipoprotein Eprovided by RGD
Primary source: RGD:2138
See related: Ensembl:ENSRNOG00000018454 AllianceGenome:RGD:2138
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: APOEA
Summary: Enables several functions, including amyloid-beta binding activity; hydroxyapatite binding activity; and phospholipid binding activity. Involved in several processes, including cellular response to alcohol; neurogenesis; and regulation of lipid metabolic process. Located in several cellular components, including late endosome; neuronal cell body; and nuclear envelope. Is extrinsic component of external side of plasma membrane. Part of several cellular components, including discoidal high-density lipoprotein particle; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Colocalizes with early endosome and microtubule. Used to study artery disease (multiple); familial hyperlipidemia; fatty liver disease (multiple); glomerulosclerosis; and middle cerebral artery infarction. Biomarker of several diseases, including glomerulonephritis (multiple); hyperhomocysteinemia; hypertension; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 45248.9), Adrenal (RPKM 6775.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Apoe in Genome Data Viewer

Location:: 1q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88481889..88485816, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (79353924..79357852, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80612894..80616820, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of ApoE in fatty acid transport from neurons to astrocytes under ischemia/hypoxia conditions.
Title: The role of ApoE in fatty acid transport from neurons to astrocytes under ischemia/hypoxia conditions.
Apolipoprotein E-depletion accelerates arterial fat deposition in the spontaneously hypertensive rat.
Title: Apolipoprotein E-depletion accelerates arterial fat deposition in the spontaneously hypertensive rat.
Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-kappaB Signaling Pathway.
Title: Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway.
Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats.
Title: Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats.
ApoE4 attenuates cortical neuronal activity in young behaving apoE4 rats.
Title: ApoE4 attenuates cortical neuronal activity in young behaving apoE4 rats.
Cdc42 Facilitates Axonogenesis by Enhancing Microtubule Stabilization in Primary Hippocampal Neurons.
Title: Cdc42 Facilitates Axonogenesis by Enhancing Microtubule Stabilization in Primary Hippocampal Neurons.
Astrocytic expression of the Alzheimer's disease risk allele, ApoEepsilon4, potentiates neuronal tau pathology in multiple preclinical models.
Title: Astrocytic expression of the Alzheimer's disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models.
Apolipoprotein E4 Is Associated with Right Ventricular Dysfunction in Dilated Cardiomyopathy-An Animal and In-Human Comparative Study.
Title: Apolipoprotein E4 Is Associated with Right Ventricular Dysfunction in Dilated Cardiomyopathy-An Animal and In-Human Comparative Study.
The inhibition of HDAC6 activity was also demonstrated to reduce brain injury induced by APOE4 and Abeta140 coaggregation in model rats.
Title: Inhibition of HDAC6 expression decreases brain injury induced by APOE4 and Aβ co‑aggregation in rats.
Data demonstrated that mechanical injury of neurons stimulated oligodendrocytes to secrete apoE. The injured neurons could absorb secreted apoE. The expression of apoE contributed to the activation of p38 MAPK, which facilitated neuron repair.
Title: The absorption of apolipoprotein E by damaged neurons facilitates neuronal repair.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94459 (e-PCR)
- UniSTS:119707

NoName (e-PCR)
- UniSTS:532416

Apoe (e-PCR), detects polymorphism
- UniSTS:532416

RH94767 (e-PCR)
- UniSTS:120014

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	ISS Inferred from Sequence or Structural Similarity more info
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	IEA Inferred from Electronic Annotation more info
enables heparan sulfate proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydroxyapatite binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipid transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid transporter activity	IEA Inferred from Electronic Annotation more info
enables lipid transporter activity	ISO Inferred from Sequence Orthology more info
enables lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal chelating activity	IEA Inferred from Electronic Annotation more info
enables metal chelating activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables tau protein binding	IEA Inferred from Electronic Annotation more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables very-low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info
enables very-low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in AMPA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in NMDA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect NMDA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in acylglycerol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid precursor protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in amyloid precursor protein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within artery morphogenesis	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cholesterol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cholesterol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in chylomicron remnant clearance	IEA Inferred from Electronic Annotation more info
involved_in chylomicron remnant clearance	ISO Inferred from Sequence Orthology more info
involved_in chylomicron remnant clearance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within circulatory system development	ISO Inferred from Sequence Orthology more info
involved_in fatty acid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in fatty acid homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle assembly	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in high-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in intermediate-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
involved_in intermediate-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in intermediate-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipid transport involved in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lipoprotein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in locomotory exploration behavior	IEA Inferred from Electronic Annotation more info
involved_in locomotory exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid transport	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	IEA Inferred from Electronic Annotation more info
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maintenance of location in cell	ISO Inferred from Sequence Orthology more info
involved_in melanosome organization	IEA Inferred from Electronic Annotation more info
involved_in melanosome organization	ISO Inferred from Sequence Orthology more info
involved_in melanosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid fibril formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of postsynaptic membrane organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection regeneration	TAS Traceable Author Statement more info	PubMed
involved_in nitric oxide-cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide-cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in peripheral nervous system axon regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in phospholipid efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid efflux	IEA Inferred from Electronic Annotation more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation by host of viral process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid transport across blood-brain barrier	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of low-density lipoprotein particle receptor catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of low-density lipoprotein particle receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurofibrillary tangle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid efflux	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of presynaptic membrane organization	ISO Inferred from Sequence Orthology more info
involved_in protein import	IEA Inferred from Electronic Annotation more info
involved_in protein import	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of Cdc42 protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of Cdc42 protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid fibril formation	IEA Inferred from Electronic Annotation more info
involved_in regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid-beta clearance	IEA Inferred from Electronic Annotation more info
involved_in regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of behavioral fear response	IEA Inferred from Electronic Annotation more info
involved_in regulation of behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to very-low-density lipoprotein particle stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to very-low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of plasma lipoprotein particle levels	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of triglyceride metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to D-galactosamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to caloric restriction	IEA Inferred from Electronic Annotation more info
involved_in response to caloric restriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in reverse cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride-rich lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in triglyceride-rich lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within vasodilation	ISO Inferred from Sequence Orthology more info
involved_in very-low-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
involved_in very-low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in very-low-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in very-low-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in virion assembly	IEA Inferred from Electronic Annotation more info
involved_in virion assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
part_of chylomicron	IBA Inferred from Biological aspect of Ancestor more info
part_of chylomicron	IDA Inferred from Direct Assay more info	PubMed
part_of chylomicron	IEA Inferred from Electronic Annotation more info
part_of chylomicron	ISO Inferred from Sequence Orthology more info
part_of chylomicron remnant	IEA Inferred from Electronic Annotation more info
part_of chylomicron remnant	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of discoidal high-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in extracellular vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in extrinsic component of external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of intermediate-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of intermediate-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of intermediate-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
part_of lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of low-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IEA Inferred from Electronic Annotation more info
located_in multivesicular body, internal vesicle	IEA Inferred from Electronic Annotation more info
located_in multivesicular body, internal vesicle	ISO Inferred from Sequence Orthology more info
located_in multivesicular body, internal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic cleft	IEA Inferred from Electronic Annotation more info
is_active_in synaptic cleft	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein E

Names: apo-E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270681.1 → NP_001257610.1 apolipoprotein E precursor

See identical proteins and their annotated locations for NP_001257610.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.

Source sequence(s)

BC086581, JAXUCZ010000001

UniProtKB/Swiss-Prot

P02650

UniProtKB/TrEMBL

A6J8R8, Q6PAH0

Related

ENSRNOP00000092257.1, ENSRNOT00000108411.1

Conserved Domains (3) summary

pfam01442
Location:78 → 256

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl03075
Location:55 → 124

GrpE; nucleotide exchange factor GrpE

cl21478
Location:209 → 291

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001270682.1 → NP_001257611.1 apolipoprotein E precursor

See identical proteins and their annotated locations for NP_001257611.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

BC086581, JAXUCZ010000001

UniProtKB/Swiss-Prot

P02650

UniProtKB/TrEMBL

A6J8R8, Q6PAH0

Conserved Domains (3) summary

pfam01442
Location:78 → 256

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl03075
Location:55 → 124

GrpE; nucleotide exchange factor GrpE

cl21478
Location:209 → 291

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001270683.1 → NP_001257612.1 apolipoprotein E precursor

See identical proteins and their annotated locations for NP_001257612.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

BC086581, JAXUCZ010000001

UniProtKB/Swiss-Prot

P02650

UniProtKB/TrEMBL

A6J8R8, Q6PAH0

Related

ENSRNOP00000071702.1, ENSRNOT00000080453.2

Conserved Domains (3) summary

pfam01442
Location:78 → 256

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl03075
Location:55 → 124

GrpE; nucleotide exchange factor GrpE

cl21478
Location:209 → 291

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001270684.1 → NP_001257613.1 apolipoprotein E precursor

See identical proteins and their annotated locations for NP_001257613.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

BC086581, JAXUCZ010000001

UniProtKB/Swiss-Prot

P02650

UniProtKB/TrEMBL

A6J8R8, Q6PAH0

Conserved Domains (3) summary

pfam01442
Location:78 → 256

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl03075
Location:55 → 124

GrpE; nucleotide exchange factor GrpE

cl21478
Location:209 → 291

ATP-synt_B; ATP synthase B/B' CF(0)
NM_138828.3 → NP_620183.2 apolipoprotein E precursor

See identical proteins and their annotated locations for NP_620183.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

BC086581, JAXUCZ010000001

UniProtKB/Swiss-Prot

P02650

UniProtKB/TrEMBL

A6J8R8, Q6PAH0

Conserved Domains (3) summary

pfam01442
Location:78 → 256

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl03075
Location:55 → 124

GrpE; nucleotide exchange factor GrpE

cl21478
Location:209 → 291

ATP-synt_B; ATP synthase B/B' CF(0)