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    Iars isoleucyl-tRNA synthetase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306804, updated on 26-Sep-2017
    Official Symbol
    Iarsprovided by RGD
    Official Full Name
    isoleucyl-tRNA synthetaseprovided by RGD
    Primary source
    RGD:621022
    See related
    Ensembl:ENSRNOG00000014616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Iarsl
    Summary
    participates in the carotid neointimal formation [RGD, Feb 2006]
    Orthologs
    Location:
    17p14
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (15356016..15402680, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (17414466..17461119, complement) , (16604188..16614960, complement)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690246 Neighboring gene spermatogenesis-associated protein 31A6-like Neighboring gene high mobility group protein B1-like Neighboring gene similar to chromosome 9 open reading frame 79 Neighboring gene nucleolar protein 8 Neighboring gene osteoglycin Neighboring gene hypothetical protein LOC679342

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
     
    isoleucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    isoleucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    isoleucine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    isoleucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    isoleucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    isoleucyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of translational fidelity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    isoleucine--tRNA ligase, cytoplasmic
    Names
    isoleucine-tRNA synthetase
    isoleucyl-tRNA synthetase, cytoplasmic
    NP_001094042.1
    XP_006253768.1
    XP_008769755.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100572.1NP_001094042.1  isoleucine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_001094042.1

      Status: VALIDATED

      Source sequence(s)
      AABR07072539
      UniProtKB/TrEMBL
      F1LS86
      Related
      ENSRNOP00000019862.6, ENSRNOT00000019862.6
      Conserved Domains (3) summary
      cd07961
      Location:640833
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:406640
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:61070
      PLN02882; aminoacyl-tRNA ligase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      15356016..15402680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253706.3XP_006253768.1  isoleucine--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006253768.1

      UniProtKB/TrEMBL
      F1LS86
      Related
      ENSRNOP00000076307.1, ENSRNOT00000093637.1
      Conserved Domains (3) summary
      cd07961
      Location:640833
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:406640
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:61070
      PLN02882; aminoacyl-tRNA ligase
    2. XM_008771533.2XP_008769755.1  isoleucine--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_008769755.1

      UniProtKB/TrEMBL
      F1LS86
      Related
      ENSRNOP00000069534.1, ENSRNOT00000086344.1
      Conserved Domains (3) summary
      cd07961
      Location:640833
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:406640
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:61070
      PLN02882; aminoacyl-tRNA ligase

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      14672657..14718804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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