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    Hmox1 heme oxygenase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24451, updated on 8-Oct-2017
    Official Symbol
    Hmox1provided by RGD
    Official Full Name
    heme oxygenase 1provided by RGD
    Primary source
    RGD:2806
    See related
    Ensembl:ENSRNOG00000014117
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ho1; Heox; Hmox; Ho-1; HEOXG; hsp32
    Summary
    catalyzes the oxidative cleavage of heme to biliverdin [RGD, Feb 2006]
    Orthologs
    Location:
    19p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (14508634..14515455)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (25622556..25629377)

    Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 Neighboring gene zinc finger protein 82 Neighboring gene minichromosome maintenance complex component 5 Neighboring gene RASD family, member 2

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heme binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heme oxygenase (decyclizing) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heme oxygenase (decyclizing) activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase D activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to cisplatin IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cisplatin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    erythrocyte homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heme catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heme catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heme metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heme oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    heme oxidation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    liver regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of mast cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mast cell degranulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of muscle cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of vascular smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phospholipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter in response to iron IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter in response to iron ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    response to nicotine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    wound healing involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    heme oxygenase 1
    Names
    heme oxygenase (decycling) 1
    heme oxygenase (decyclizing) 1
    NP_036712.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012580.2NP_036712.1  heme oxygenase 1

      See identical proteins and their annotated locations for NP_036712.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091164
      UniProtKB/Swiss-Prot
      P06762
      Related
      ENSRNOP00000019192.4, ENSRNOT00000019192.6
      Conserved Domains (1) summary
      pfam01126
      Location:11216
      Heme_oxygenase; Heme oxygenase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

      Range
      14508634..14515455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000087.1 Alternate Rn_Celera

      Range
      13334259..13341080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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