Dtna dystrobrevin alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dtnaprovided by MGI
Official Full Name: dystrobrevin alphaprovided by MGI
Primary source: MGI:MGI:106039
See related: Ensembl:ENSMUSG00000024302 AllianceGenome:MGI:106039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dtn; adbn; DTN-A; a-DB-1; Gm19389; 2210407P21Rik
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in synaptic signaling. Located in synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sensory organ. Human ortholog(s) of this gene implicated in cardiomyopathy and left ventricular noncompaction. Orthologous to human DTNA (dystrobrevin alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 9.3), cortex adult (RPKM 8.0) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A2; 18 12.08 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (23443063..23792776)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (23310006..23659719)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression.
Title: α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression.
Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle.
Title: Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle.
Phosphorylation of alpha-dystrobrevin is essential for alphakap accumulation and acetylcholine receptor stability.
Title: Phosphorylation of α-dystrobrevin is essential for αkap accumulation and acetylcholine receptor stability.
these results demonstrated that, by inhibiting the activity of DTNA-mediated Notch1 axis, miR-374 could protect against myocardial I/R injury in mice after thoracic epidural anesthesia
Title: Protective role of microRNA-374 against myocardial ischemia-reperfusion injury in mice following thoracic epidural anesthesia by downregulating dystrobrevin alpha-mediated Notch1 axis.
A phosphorylation site on alpha-dystrobrevin-1 is essential for functional interactions with several proteins at the neuromuscular junction.
Title: Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction.
Alpha-dystrobrevin is a multifunctional protein that increases dystrophin's binding to the dystrophin-glycoprotein complex.
Title: Dystrobrevin increases dystrophin's binding to the dystrophin-glycoprotein complex and provides protection during cardiac stress.
Loss of alpha dystrobrevin is associated with perturbation in cell cycle progression and nuclei shape.
Title: Nuclear localization of the dystrophin-associated protein α-dystrobrevin through importin α2/β1 is critical for interaction with the nuclear lamina/maintenance of nuclear integrity.
Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology.
Title: Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology.
alpha-dystrobrevin emerges as a central organizer of dystrophin-associated protein in glial endfeet and a rare example of a glial protein with a role in maintaining BBB function
Title: Absence of glial α-dystrobrevin causes abnormalities of the blood-brain barrier and progressive brain edema.
the interaction between alpha-catulin and alpha-dystrobrevin is evolutionarily conserved in C. elegans and mouse muscles and strongly suggests that this interaction contributes to the integrity of the dystrophin complex
Title: Interaction of α-catulin with dystrobrevin contributes to integrity of dystrophin complex in muscle.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dtna (e-PCR), detects polymorphism
- UniSTS:142875

Dtna (e-PCR), detects polymorphism
- UniSTS:464668

NoName (e-PCR)
- UniSTS:224388

BE096939 (e-PCR)
- UniSTS:244128

stSG614866 (e-PCR)
- UniSTS:450744

D18Mit172 (e-PCR), detects polymorphism
- UniSTS:128193

UniSTS:257001 (e-PCR)
- UniSTS:257001

Dtna (e-PCR), detects polymorphism
- UniSTS:257001

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in synaptic signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of dystrobrevin complex	NAS Non-traceable Author Statement more info	PubMed
located_in extrinsic component of cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	TAS Traceable Author Statement more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dystrobrevin alpha

Names: alpha-dystrobrevin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285807.1 → NP_001272736.1 dystrobrevin alpha isoform a

See identical proteins and their annotated locations for NP_001272736.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC111031, AC133182, AC163102, AK019477, BB337232, BY127150

Consensus CDS

CCDS89200.1

UniProtKB/Swiss-Prot

P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0

UniProtKB/TrEMBL

A0A1Y7VL34

Related

ENSMUSP00000152288.2, ENSMUST00000220904.2

Conserved Domains (3) summary

COG0419
Location:422 → 557

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
NM_001285808.1 → NP_001272737.1 dystrobrevin alpha isoform b

See identical proteins and their annotated locations for NP_001272737.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR and lacks two in-frame exons in the coding region compared to variant 1. The encoded protein (isoform b) is shorter than isoform a.

Source sequence(s)

AC111031, AC163102

UniProtKB/TrEMBL

I6L9D6

Conserved Domains (4) summary

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:16 → 140

EF-hand_2; EF hand

pfam09069
Location:144 → 232

EF-hand_3; EF-hand

pfam11068
Location:414 → 502

YlqD; YlqD protein
NM_001285810.1 → NP_001272739.1 dystrobrevin alpha isoform c

See identical proteins and their annotated locations for NP_001272739.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR and has multiple differences in the coding region compared to variant 1. The resulting protein (isoform c) maintains the reading frame, and is shorter compared to isoform a. Variants 3 and 4 encode the same protein.

Source sequence(s)

AC163102, AK019477, AK147359, BB337232

UniProtKB/TrEMBL

Q3UHJ2, Q3UHP1

Conserved Domains (3) summary

COG0419
Location:368 → 497

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
NM_001285811.1 → NP_001272740.1 dystrobrevin alpha isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 3' coding region and contains an alternate 3' terminal exon. The encoded protein (isoform e) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AC111031, AC133182, AC163102, AW455975

UniProtKB/TrEMBL

A0A1Y7VJN9

Conserved Domains (4) summary

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:16 → 140

EF-hand_2; EF hand

pfam09069
Location:144 → 232

EF-hand_3; EF-hand

pfam11068
Location:471 → 568

YlqD; YlqD protein
NM_001285813.1 → NP_001272742.1 dystrobrevin alpha isoform c

See identical proteins and their annotated locations for NP_001272742.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR and has multiple differences in the coding region compared to variant 1. The resulting protein (isoform c) maintains the reading frame, and is shorter compared to isoform a. Variants 3 and 4 encode the same protein.

Source sequence(s)

AK147279, BB337232, BY122991

UniProtKB/TrEMBL

Q3UHJ2, Q3UHP1

Conserved Domains (3) summary

COG0419
Location:368 → 497

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
NM_001285817.1 → NP_001272746.1 dystrobrevin alpha isoform d

See identical proteins and their annotated locations for NP_001272746.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, 3' UTR and lacks three in-frame exons in the coding region compared to variant 1. The encoded protein (isoform d) is shorter than isoform a. Variants 5 and 6 encode the same protein.

Source sequence(s)

AC163102, AK019477, AK131649, AK147279, AK147359, BB337232

Consensus CDS

CCDS50236.1

UniProtKB/TrEMBL

I6L9D6, Q8CFR5

Conserved Domains (3) summary

COG0419
Location:365 → 494

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
NM_001361215.1 → NP_001348144.1 dystrobrevin alpha isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (9) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (d) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC111031, AC163102

Consensus CDS

CCDS50236.1

UniProtKB/TrEMBL

I6L9D6, Q8CFR5

Conserved Domains (3) summary

COG0419
Location:365 → 494

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
NM_001361216.1 → NP_001348145.1 dystrobrevin alpha isoform g

Status: VALIDATED

Description

Transcript Variant: This variant (10) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform g) is shorter than isoform 1.

Source sequence(s)

AC111031, AC133182, AC163102

UniProtKB/TrEMBL

I6L9D6

Conserved Domains (4) summary

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR03752
Location:388 → 595

conj_TIGR03752; integrating conjugative element protein, PFL_4705 family

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

cl28419
Location:416 → 486

SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
NM_001361217.1 → NP_001348146.1 dystrobrevin alpha isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (11) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform d) is shorter than isoform 1.

Source sequence(s)

AC111031, AC133182, AC163102

Consensus CDS

CCDS50236.1

UniProtKB/TrEMBL

I6L9D6, Q8CFR5

Conserved Domains (3) summary

COG0419
Location:365 → 494

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
NM_010087.4 → NP_034217.2 dystrobrevin alpha isoform f

See identical proteins and their annotated locations for NP_034217.2

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 3' coding region and contains an alternate 3' terminal exon. The encoded protein (isoform f) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AC133182, AK003829, BU700818, BY127150

Consensus CDS

CCDS29094.1

UniProtKB/TrEMBL

Q8BTD9

Related

ENSMUSP00000037475.8, ENSMUST00000047954.15

Conserved Domains (2) summary

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
NM_207650.4 → NP_997533.1 dystrobrevin alpha isoform d

See identical proteins and their annotated locations for NP_997533.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR and lacks three in-frame exons in the coding region compared to variant 1. The encoded protein (isoform d) is shorter than isoform a. Variants 5 and 6 encode the same protein.

Source sequence(s)

AC111031, AC133182, AC163102

Consensus CDS

CCDS50236.1

UniProtKB/TrEMBL

I6L9D6, Q8CFR5

Related

ENSMUSP00000111498.3, ENSMUST00000115832.4

Conserved Domains (3) summary

COG0419
Location:365 → 494

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

23443063..23792776

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250320.2 → XP_030106180.1 dystrobrevin alpha isoform X7

UniProtKB/TrEMBL

I6L9D6, Q8CFR5

Conserved Domains (3) summary

COG0419
Location:365 → 494

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_036160978.1 → XP_036016871.1 dystrobrevin alpha isoform X7

UniProtKB/TrEMBL

I6L9D6, Q8CFR5

Conserved Domains (3) summary

COG0419
Location:365 → 494

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_036160979.1 → XP_036016872.1 dystrobrevin alpha isoform X9

UniProtKB/TrEMBL

A0A1Y7VJN9

Related

ENSMUSP00000152565.2, ENSMUST00000221880.2

Conserved Domains (3) summary

COG0419
Location:365 → 497

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_036160981.1 → XP_036016874.1 dystrobrevin alpha isoform X11

UniProtKB/TrEMBL

Q8BTD9

Conserved Domains (2) summary

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_036160973.1 → XP_036016866.1 dystrobrevin alpha isoform X2

UniProtKB/Swiss-Prot

P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0

Conserved Domains (3) summary

COG0419
Location:425 → 560

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_036160974.1 → XP_036016867.1 dystrobrevin alpha isoform X2

UniProtKB/Swiss-Prot

P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0

Conserved Domains (3) summary

COG0419
Location:425 → 560

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_036160972.1 → XP_036016865.1 dystrobrevin alpha isoform X1

UniProtKB/Swiss-Prot

P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0

Conserved Domains (3) summary

COG0419
Location:425 → 560

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_011246830.1 → XP_011245132.1 dystrobrevin alpha isoform X4

UniProtKB/Swiss-Prot

P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0

Conserved Domains (4) summary

PRK05431
Location:476 → 546

PRK05431; seryl-tRNA synthetase; Provisional

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR03752
Location:448 → 655

conj_TIGR03752; integrating conjugative element protein, PFL_4705 family

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_017317811.1 → XP_017173300.1 dystrobrevin alpha isoform X4

UniProtKB/Swiss-Prot

P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0

Conserved Domains (4) summary

PRK05431
Location:476 → 546

PRK05431; seryl-tRNA synthetase; Provisional

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR03752
Location:448 → 655

conj_TIGR03752; integrating conjugative element protein, PFL_4705 family

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_036160976.1 → XP_036016869.1 dystrobrevin alpha isoform X6

UniProtKB/TrEMBL

Q3UHJ2, Q3UHP1

Conserved Domains (3) summary

COG0419
Location:368 → 497

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_036160975.1 → XP_036016868.1 dystrobrevin alpha isoform X3

UniProtKB/Swiss-Prot

P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0

UniProtKB/TrEMBL

A0A1Y7VL34

Conserved Domains (3) summary

COG0419
Location:422 → 557

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_011246838.1 → XP_011245140.1 dystrobrevin alpha isoform X12

UniProtKB/Swiss-Prot

P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0

Conserved Domains (4) summary

PRK05431
Location:473 → 543

PRK05431; seryl-tRNA synthetase; Provisional

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR03752
Location:445 → 652

conj_TIGR03752; integrating conjugative element protein, PFL_4705 family

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_011246833.1 → XP_011245135.1 dystrobrevin alpha isoform X5

UniProtKB/Swiss-Prot

P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0

Conserved Domains (4) summary

PRK05431
Location:447 → 517

PRK05431; seryl-tRNA synthetase; Provisional

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR03752
Location:419 → 626

conj_TIGR03752; integrating conjugative element protein, PFL_4705 family

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_030250321.1 → XP_030106181.1 dystrobrevin alpha isoform X8

UniProtKB/TrEMBL

A0A1Y7VJN9

Conserved Domains (3) summary

COG0419
Location:368 → 503

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
XM_030250323.1 → XP_030106183.1 dystrobrevin alpha isoform X10

Conserved Domains (2) summary

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16249
Location:54 → 214

EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin