U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rassf1 Ras association (RalGDS/AF-6) domain family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 56289, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rassf1provided by MGI
    Official Full Name
    Ras association (RalGDS/AF-6) domain family member 1provided by MGI
    Primary source
    MGI:MGI:1928386
    See related
    Ensembl:ENSMUSG00000010067 AllianceGenome:MGI:1928386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    123F2; RDA32; NORE2A; REH3P21; Rassf1A; Rassf1B; Rassf1C
    Summary
    Enables small GTPase binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; positive regulation of protein ubiquitination; and protein stabilization. Predicted to be located in cytoplasm and microtubule. Predicted to be active in microtubule cytoskeleton and nucleus. Is expressed in liver and metanephros. Human ortholog(s) of this gene implicated in breast cancer; reproductive organ cancer (multiple); transitional cell carcinoma; and urinary system cancer (multiple). Orthologous to human RASSF1 (Ras association domain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 22.7), testis adult (RPKM 20.7) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    9 F1; 9 58.12 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107428752..107439460)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107551434..107562267)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10584 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E3857 Neighboring gene zinc finger, MYND domain containing 10 Neighboring gene predicted gene, 34106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107453431-107453584 Neighboring gene STARR-positive B cell enhancer ABC_E9335 Neighboring gene predicted gene 9917 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene STARR-positive B cell enhancer ABC_E2304 Neighboring gene hyaluronoglucosaminidase 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid Biopsies in Patients With Pediatric Solid Tumors. van Zogchel LMJ, et al. JCO Precis Oncol, 2021. PMID 34820594, Free PMC Article
    2. RASSF1-AS1, an antisense lncRNA of RASSF1A, inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice. Guo M, et al. Cell Biol Int, 2019 Oct. PMID 30571844
    3. RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis. Schmidt ML, et al. Cancer Res, 2018 May 15. PMID 29735543, Free PMC Article
    4. Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. Del Re DP, et al. J Clin Invest, 2010 Oct. PMID 20890045, Free PMC Article
    5. Megaoesophagus in Rassf1a-null mice. van der Weyden L, et al. Int J Exp Pathol, 2009 Apr. PMID 19335548, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RASSF1A promotes ATM signaling and RASSF1A methylation is a synthetic lethal marker for ATR inhibitors.
      Title: RASSF1A promotes ATM signaling and RASSF1A methylation is a synthetic lethal marker for ATR inhibitors.
    2. WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.
      Title: WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.
    3. RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.
      Title: RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.
    4. Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid Biopsies in Patients With Pediatric Solid Tumors.
      Title: Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid Biopsies in Patients With Pediatric Solid Tumors.
    5. The RASSF1A negatively regulates NF-kappaB and thereby attenuates inflammatory cytokine expression.
      Title: The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium.
    6. Findings indicate that compared with the alcoholic steatohepatitis (ASH) group of patients, the expression levels of all three tumor suppressor genes (TSGs) proteins, RUNX family transcription factor 3 (RUNX3), glutathione S-transferase pi 1 (GSTP1), and RASSF1A tumor suppressor (RASSF1), were significantly lower in the non-alcoholic steatohepatitis (NASH) group of patients.
      Title: The different expression of tumor suppressors, RASSF1A, RUNX3, and GSTP1, in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH).
    7. The authors show that an antisense lncRNA of RASSF1A inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice, indicating a potential application of RASSF1-AS1 as a therapy target for cardiac fibrosis.
      Title: RASSF1-AS1, an antisense lncRNA of RASSF1A, inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice.
    8. Study show that hypoxia promotes stabilization of RASSF1A through NOX-1- and protein kinase C- dependent phosphorylation. HIF-1alpha activates RASSF1A transcription via HIF-binding sites in the RASSF1A promoter region. RASSF1A binds to HIF-1alpha, blocks its prolyl-hydroxylation and proteasomal degradation. Study concludes that RASSF1A-HIF-1alpha forms a feedforward loop driving hypoxia signaling in pulmonary hypertens...
      Title: A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension.
    9. The authors found that haploinsufficiency of Rassf1a was sufficient to dramatically enhance the tumorigenicity of K-Ras in the system.
      Title: RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis.
    10. RASSF1A is expressed in differentiating stem cells.RASSF1A promotes YAP and p73 binding to differentiation related genes.RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.
      Title: RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_negative_effect regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ras association domain-containing protein 1
    Names
    123F protein
    RASSF1A tumor suppressor
    Ras association (RalGDS/AF-6) domain family 1
    protein 123F2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243748.2 → NP_001230677.1  ras association domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001230677.1

      Status: VALIDATED

      Source sequence(s)
      AL672219
      Consensus CDS
      CCDS57699.1
      UniProtKB/Swiss-Prot
      Q99MK9, Q9WUF5
      UniProtKB/TrEMBL
      A9YZW8, B0QZV7
      Related
      ENSMUSP00000091301.3, ENSMUST00000093786.9
      Conserved Domains (3) summary
      cd00029
      Location:52 → 101
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd17218
      Location:130 → 286
      RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
      pfam16517
      Location:295 → 334
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

    2. NM_001411798.1 → NP_001398727.1  ras association domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672219
      UniProtKB/TrEMBL
      Q3UIV8

    3. NM_001411799.1 → NP_001398728.1  ras association domain-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672219

    4. NM_001411800.1 → NP_001398729.1  ras association domain-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672219

    5. NM_001411801.1 → NP_001398730.1  ras association domain-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672219

    6. NM_019713.5 → NP_062687.1  ras association domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_062687.1

      Status: VALIDATED

      Source sequence(s)
      AL672219
      Consensus CDS
      CCDS23494.1
      UniProtKB/Swiss-Prot
      Q99MK9
      UniProtKB/TrEMBL
      Q3UIV8
      Related
      ENSMUSP00000010211.5, ENSMUST00000010211.7
      Conserved Domains (2) summary
      cd17218
      Location:60 → 216
      RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
      pfam16517
      Location:225 → 264
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107428752..107439460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MK9.1 GenPept UniProtKB/Swiss-Prot:Q99MK9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous