Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CDC14B cell division cycle 14B [ Homo sapiens (human) ]

    Gene ID: 8555, updated on 12-Aug-2018

    Summary

    Official Symbol
    CDC14Bprovided by HGNC
    Official Full Name
    cell division cycle 14Bprovided by HGNC
    Primary source
    HGNC:HGNC:1719
    See related
    Ensembl:ENSG00000081377 MIM:603505; Vega:OTTHUMG00000020300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC14B3; Cdc14B1; Cdc14B2; hCDC14B
    Summary
    The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 5.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See CDC14B in Genome Data Viewer
    Location:
    9q22.32-q22.33
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (96492743..96619830, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (99252807..99382112, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis homolog (S. cerevisiae) pseudogene Neighboring gene zinc finger protein 367 Neighboring gene hyaluronan binding protein 4 Neighboring gene uncharacterized LOC105376163 Neighboring gene peroxiredoxin like 2C Neighboring gene makorin ring finger protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cell Cycle, organism-specific biosystem (from WikiPathways)
      Cell Cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
      MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
    • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
      MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
    • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK1 signaling events, organism-specific biosystem
      PLK1 signaling events
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
     
    protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of exit from mitosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signal transduction involved in G2 DNA damage checkpoint IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity protein phosphatase CDC14B
    Names
    CDC14 cell division cycle 14 homolog B
    NP_001070649.1
    NP_001338496.1
    NP_001338497.1
    NP_001338498.1
    NP_001338499.1
    NP_003662.1
    NP_201588.1
    XP_011517449.2
    XP_011517450.2
    XP_011517451.2
    XP_011517453.2
    XP_011517454.2
    XP_011517455.2
    XP_011517458.2
    XP_011517460.1
    XP_011517461.2
    XP_016870729.2
    XP_016870730.2
    XP_016870731.1
    XP_016870733.1
    XP_016870734.1
    XP_016870736.1
    XP_016870737.1
    XP_016870738.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077181.2NP_001070649.1  dual specificity protein phosphatase CDC14B isoform 3

      See identical proteins and their annotated locations for NP_001070649.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 2, resulting in a protein (isoform 3) that has an alternate N-terminus, compared to isoform 2.
      Source sequence(s)
      AK126388, AL133477, BQ004840, DB089608
      Consensus CDS
      CCDS43853.1
      UniProtKB/Swiss-Prot
      O60729
      Related
      ENSP00000364390.3, OTTHUMP00000215877, ENST00000375242.7
      Conserved Domains (2) summary
      pfam14671
      Location:15152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:209323
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_001351567.1NP_001338496.1  dual specificity protein phosphatase CDC14B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AF064104, AI921238, BF979799, BM687919, EF611343
      Consensus CDS
      CCDS87662.1
      Related
      ENSP00000420572.1, ENST00000463569.5
      Conserved Domains (2) summary
      pfam14671
      Location:52189
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:246360
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. NM_001351568.1NP_001338497.1  dual specificity protein phosphatase CDC14B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AI921238, BF979799, BM687919, DB089608, EF611343
      Conserved Domains (2) summary
      pfam14671
      Location:15152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:209323
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    4. NM_001351569.1NP_001338498.1  dual specificity protein phosphatase CDC14B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK126388, AL133477, BP272794, BQ004840, DA943563, DB089608
      Conserved Domains (2) summary
      pfam14671
      Location:15152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:209323
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    5. NM_001351570.1NP_001338499.1  dual specificity protein phosphatase CDC14B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AK126388, AL133477, BG709497, BP272794, BQ004840, DB089608
      Conserved Domains (2) summary
      pfam14671
      Location:29166
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:223337
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    6. NM_003671.4NP_003662.1  dual specificity protein phosphatase CDC14B isoform 1

      See identical proteins and their annotated locations for NP_003662.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 2, resulting in a shorter protein (isoform 1) that lacks an internal segment in the C-terminal region, compared to isoform 2.
      Source sequence(s)
      AF064104, AL133477, BQ004840
      Consensus CDS
      CCDS6721.1
      UniProtKB/Swiss-Prot
      O60729
      Related
      ENSP00000364388.3, OTTHUMP00000021730, ENST00000375240.7
      Conserved Domains (2) summary
      pfam14671
      Location:52189
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:246360
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    7. NM_033331.3NP_201588.1  dual specificity protein phosphatase CDC14B isoform 2

      See identical proteins and their annotated locations for NP_201588.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AF064104, AL133477, BQ004840
      Consensus CDS
      CCDS6722.1
      UniProtKB/Swiss-Prot
      O60729
      Related
      ENSP00000364389.1, OTTHUMP00000021729, ENST00000375241.5
      Conserved Domains (2) summary
      pfam14671
      Location:52189
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:246360
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RNA

    1. NR_147239.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AF064104, AK225361, AL133477, AL353578, BQ004840

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      96492743..96619830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519158.1XP_011517460.1  dual specificity protein phosphatase CDC14B isoform X13

      UniProtKB/Swiss-Prot
      O60729
      Related
      ENSP00000417897.1, OTTHUMP00000215879, ENST00000474602.5, OTTHUMT00000053277
      Conserved Domains (2) summary
      pfam14671
      Location:52189
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:246360
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. XM_011519152.3XP_011517454.2  dual specificity protein phosphatase CDC14B isoform X6

      Conserved Domains (2) summary
      pfam14671
      Location:29166
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:223337
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. XM_011519147.3XP_011517449.2  dual specificity protein phosphatase CDC14B isoform X2

      Conserved Domains (2) summary
      pfam14671
      Location:29166
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:223337
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    4. XM_011519149.3XP_011517451.2  dual specificity protein phosphatase CDC14B isoform X4

      Conserved Domains (2) summary
      pfam14671
      Location:29166
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:223337
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    5. XM_017015242.2XP_016870731.1  dual specificity protein phosphatase CDC14B isoform X9

    6. XM_017015248.2XP_016870737.1  dual specificity protein phosphatase CDC14B isoform X15

    7. XM_011519156.3XP_011517458.2  dual specificity protein phosphatase CDC14B isoform X10

    8. XM_017015241.2XP_016870730.2  dual specificity protein phosphatase CDC14B isoform X8

      Conserved Domains (2) summary
      pfam14671
      Location:29117
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:154268
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    9. XM_017015247.2XP_016870736.1  dual specificity protein phosphatase CDC14B isoform X14

    10. XM_017015244.2XP_016870733.1  dual specificity protein phosphatase CDC14B isoform X11

    11. XM_011519153.3XP_011517455.2  dual specificity protein phosphatase CDC14B isoform X7

      Conserved Domains (2) summary
      pfam14671
      Location:29166
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:223337
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    12. XM_011519148.3XP_011517450.2  dual specificity protein phosphatase CDC14B isoform X3

      Conserved Domains (2) summary
      pfam14671
      Location:29166
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:223337
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    13. XM_017015240.2XP_016870729.2  dual specificity protein phosphatase CDC14B isoform X1

      Conserved Domains (2) summary
      pfam14671
      Location:29166
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:223337
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    14. XM_011519159.3XP_011517461.2  dual specificity protein phosphatase CDC14B isoform X16

    15. XM_017015249.1XP_016870738.1  dual specificity protein phosphatase CDC14B isoform X17

    16. XM_017015245.1XP_016870734.1  dual specificity protein phosphatase CDC14B isoform X12

    17. XM_011519151.3XP_011517453.2  dual specificity protein phosphatase CDC14B isoform X5

      Conserved Domains (2) summary
      pfam14671
      Location:29166
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:223337
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RNA

    1. XR_929864.3 RNA Sequence

    2. XR_929865.3 RNA Sequence

    3. XR_002956814.1 RNA Sequence

    4. XR_001746407.1 RNA Sequence

    5. XR_001746408.1 RNA Sequence

    6. XR_001746409.2 RNA Sequence

    7. XR_001746406.2 RNA Sequence

    8. XR_929868.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033332.1: Suppressed sequence

      Description
      NM_033332.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Support Center