CD300A CD300a molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD300Aprovided by HGNC
Official Full Name: CD300a moleculeprovided by HGNC
Primary source: HGNC:HGNC:19319
See related: Ensembl:ENSG00000167851 MIM:606790; AllianceGenome:HGNC:19319
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9
Summary: This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Expression: Broad expression in spleen (RPKM 24.5), appendix (RPKM 12.1) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (74466373..74484798)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (75356904..75375324)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (72462512..72480937)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD300a and CD300f molecules regulate the function of leukocytes.
Title: CD300a and CD300f molecules regulate the function of leukocytes.
CD300 molecules participate in the mechanisms that viruses employ to develop immune evasion strategies and to infect host cells [Review].
Title: CD300 receptor family in viral infections.
Results provide an insight into the novel set of paired receptors CD300a and CD300c that are distinctively expressed on CD56(bright) natural killers (NK) cells with varied effector functions and show there differential binding to their ligands phosphatidylethanolamine and phosphatidylserine (PS) resulting in their differential ability to affect CD56(bright) NK cell functions.
Title: CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.
High CD300A expression is associated with diffuse large B-cell lymphoma.
Title: Suppression of CD300A inhibits the growth of diffuse large B-cell lymphoma.
US3 protein kinase of pseudorabies virus triggers the binding of the inhibitory natural killer cell receptor CD300a to the surface of the infected cell, and protects of virus infected cells against natural killer cell-mediated lysis.
Title: Pseudorabies Virus US3 Protein Kinase Protects Infected Cells from NK Cell-Mediated Lysis via Increased Binding of the Inhibitory NK Cell Receptor CD300a.
Overall, these data indicate that CD300a is a novel Dengue virus binding receptor that recognizes phosphatidylethanolamine and phosphatidylserine present on virions and enhance infection.
Title: The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances Infection.
Data show that peroxisome proliferator activator receptor delta (PPARdelta/beta) directly regulates CD300a protein in macrophages.
Title: PPARβ/δ activation of CD300a controls intestinal immunity.
CD300a induction by the hypoxic environment represents a mechanism of regulation of monocyte/macrophage pro-inflammatory responses at pathologic sites
Title: Identification of CD300a as a new hypoxia-inducible gene and a regulator of CCL20 and VEGF production by human monocytes and macrophages.
interaction with phosphatidylserines inhibits IgE/FcepsilonRI-dependent anaphylactic basophil degranulation
Title: Mechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a.
The inhibitory receptor CD300a is regulator of monocytes transendothelial migration.
Title: Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif downregulates the expression of CD300a molecule (CD300A) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G32451 (e-PCR)
- UniSTS:117037

D17S690 (e-PCR)
- UniSTS:42806

D17S1727E (e-PCR)
- UniSTS:153961

SHGC-132578 (e-PCR)
- UniSTS:173954

D17S1985 (e-PCR)
- UniSTS:37544

A009D33 (e-PCR)
- UniSTS:20406

SHGC-36245 (e-PCR)
- UniSTS:63951

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables phosphatidylethanolamine binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of NK T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of activation of Janus kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of eosinophil activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of eosinophil migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mast cell activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mast cell degranulation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neutrophil activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in ficolin-1-rich granule membrane	TAS Traceable Author Statement more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in tertiary granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: CMRF35-like molecule 8

Names: CD300 antigen-like family member A; CD300a antigen; CMRF35H leukocyte immunoglobulin-like receptor; NK inhibitory receptor; immunoglobulin superfamily member 12; inhibitory receptor protein 60; leukocyte membrane antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256841.2 → NP_001243770.1 CMRF35-like molecule 8 isoform 2 precursor

See identical proteins and their annotated locations for NP_001243770.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2), also referred to as IRC1c, is shorter compared to isoform 1.

Source sequence(s)

AC079325, AJ010102, BF059016

Consensus CDS

CCDS58590.1

UniProtKB/Swiss-Prot

Q9UGN4

Related

ENSP00000308188.5, ENST00000310828.9

Conserved Domains (1) summary

pfam15330
Location:86 → 160

SIT; SHP2-interacting transmembrane adaptor protein, SIT
NM_001330456.1 → NP_001317385.1 CMRF35-like molecule 8 isoform 3

Status: VALIDATED

Source sequence(s)

AC079325

Consensus CDS

CCDS82197.1

UniProtKB/TrEMBL

J3QKQ4

Related

ENSP00000497133.1, ENST00000648095.1
NM_001330457.2 → NP_001317386.1 CMRF35-like molecule 8 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC079325

Consensus CDS

CCDS82196.1

UniProtKB/Swiss-Prot

Q9UGN4

Related

ENSP00000376401.3, ENST00000392625.7
NM_007261.4 → NP_009192.2 CMRF35-like molecule 8 isoform 1 precursor

See identical proteins and their annotated locations for NP_009192.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1), also referred to as IRC1a.

Source sequence(s)

BC032352

Consensus CDS

CCDS32720.1

UniProtKB/Swiss-Prot

A8MW96, O95100, Q9HD97, Q9P0F3, Q9UBK4, Q9UGN4, Q9UMS9, Q9UMT0

Related

ENSP00000353259.3, ENST00000360141.8

Conserved Domains (3) summary

cd05716
Location:23 → 117

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:22 → 105

IG_like; Immunoglobulin like

pfam15330
Location:199 → 273

SIT; SHP2-interacting transmembrane adaptor protein, SIT

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

74466373..74484798

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005256990.4 → XP_005257047.1 CMRF35-like molecule 8 isoform X1

Conserved Domains (2) summary

cd05716
Location:23 → 117

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:22 → 105

IG_like; Immunoglobulin like
XM_005256991.6 → XP_005257048.1 CMRF35-like molecule 8 isoform X2

Conserved Domains (2) summary

cd05716
Location:23 → 117

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:22 → 105

IG_like; Immunoglobulin like