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    MEF2A myocyte enhancer factor 2A [ Homo sapiens (human) ]

    Gene ID: 4205, updated on 3-Apr-2024

    Summary

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    Official Symbol
    MEF2Aprovided by HGNC
    Official Full Name
    myocyte enhancer factor 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:6993
    See related
    Ensembl:ENSG00000068305 MIM:600660; AllianceGenome:HGNC:6993
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    mef2; ADCAD1; RSRFC4; RSRFC9
    Summary
    The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
    Expression
    Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 12.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    15q26.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (99565417..99716488)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (97329154..97480250)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (100105622..100256693)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10160 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:100105511-100106486 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:100106487-100107460 Neighboring gene ribosomal protein L7 pseudogene 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:100119332-100119832 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:100119833-100120333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10161 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:100169236-100169886 Neighboring gene MPRA-validated peak2449 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100266134-100266634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100266635-100267135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6874 Neighboring gene LysM domain containing 4 Neighboring gene MPRA-validated peak2450 silencer Neighboring gene uncharacterized LOC105371020 Neighboring gene RNA, 7SL, cytoplasmic 484, pseudogene Neighboring gene dynamin 1 pseudogene 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A PGE(2)-MEF2A axis enables context-dependent control of inflammatory gene expression. Cilenti F, et al. Immunity, 2021 Aug 10. PMID 34129840, Free PMC Article
    2. Detection and functional characterization of a novel MEF2A variation responsible for familial dilated cardiomyopathy. Qiao Q, et al. Clin Chem Lab Med, 2021 Apr 27. PMID 33554560
    3. Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. Liu B, et al. Aging (Albany NY), 2019 Jun 10. PMID 31182679, Free PMC Article
    4. MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. Xiong Y, et al. BMC Mol Biol, 2019 Mar 18. PMID 30885136, Free PMC Article
    5. Reversal of pathological cardiac hypertrophy via the MEF2-coregulator interface. Wei J, et al. JCI Insight, 2017 Sep 7. PMID 28878124, Free PMC Article

    See all (164) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
      Title: Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
    2. Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.
      Title: Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.
    3. A Study of transcription factor MEF2A gene polymorphisms in patients with coronary artery disease.
      Title: A Study of transcription factor MEF2A gene polymorphisms in patients with coronary artery disease.
    4. Association between MEF2 family gene polymorphisms and susceptibility to multiple sclerosis in Chinese population.
      Title: Association between MEF2 family gene polymorphisms and susceptibility to multiple sclerosis in Chinese population.
    5. HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation.
      Title: HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation.
    6. MiRNA-615-3p Alleviates Oxidative Stress Injury of Human Cardiomyocytes Via PI3K/Akt Signaling by Targeting MEF2A.
      Title: MiRNA-615-3p Alleviates Oxidative Stress Injury of Human Cardiomyocytes Via PI3K/Akt Signaling by Targeting MEF2A.
    7. Detection and functional characterization of a novel MEF2A variation responsible for familial dilated cardiomyopathy.
      Title: Detection and functional characterization of a novel MEF2A variation responsible for familial dilated cardiomyopathy.
    8. MEF2A transcriptionally upregulates the expression of ZEB2 and CTNNB1 in colorectal cancer to promote tumor progression.
      Title: MEF2A transcriptionally upregulates the expression of ZEB2 and CTNNB1 in colorectal cancer to promote tumor progression.
    9. MEF2A-mediated lncRNA HCP5 Inhibits Gastric Cancer Progression via MiR-106b-5p/p21 Axis.
      Title: MEF2A-mediated lncRNA HCP5 Inhibits Gastric Cancer Progression via MiR-106b-5p/p21 Axis.
    10. A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression.
      Title: A PGE(2)-MEF2A axis enables context-dependent control of inflammatory gene expression.
    Submit: New GeneRIF Correction See all GeneRIFs (85)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Coronary artery disease, autosomal dominant, 1
    MedGen: C1842247 OMIM: 608320 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Phosphorylated DING (pDING) inhibits HIV-1 Tat-induced neuronal cell injury by suppressing the activity of serine/threonine kinases p38 MAPK and Cdk5 and enhancing the activity of neuroprotective factor MEF2 through the phosphotase activity of pDING PubMed
    tat HIV-1 Tat increases levels of phosphorylated MEF2 in human neuronal cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ERK5 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cardiac conduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dendrite morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion distribution ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in muscle organ development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of glucose import IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ventricular cardiac myofibril assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    part_of chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myocyte-specific enhancer factor 2A
    Names
    MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)
    serum response factor-like protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016443.2 RefSeqGene

      Range
      5057..155561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130926.5 → NP_001124398.1  myocyte-specific enhancer factor 2A isoform 2

      See identical proteins and their annotated locations for NP_001124398.1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417, A8K720
      Related
      ENSP00000509537.1, ENST00000691492.1
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    2. NM_001130927.5 → NP_001124399.1  myocyte-specific enhancer factor 2A isoform 3

      See identical proteins and their annotated locations for NP_001124399.1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45363.1
      UniProtKB/TrEMBL
      A8K720
      Related
      ENSP00000454120.1, ENST00000558812.5
      Conserved Domains (2) summary
      pfam12347
      Location:29 → 82
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
      cl00109
      Location:2 → 25
      MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...

    3. NM_001130928.4 → NP_001124400.1  myocyte-specific enhancer factor 2A isoform 4

      See identical proteins and their annotated locations for NP_001124400.1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS58401.1
      UniProtKB/TrEMBL
      A0A0S2Z4C8, A8K720
      Related
      ENSP00000399460.2, ENST00000449277.6
      Conserved Domains (2) summary
      pfam12347
      Location:29 → 81
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
      cl00109
      Location:2 → 25
      MADS; MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type ...

    4. NM_001171894.5 → NP_001165365.1  myocyte-specific enhancer factor 2A isoform 2

      See identical proteins and their annotated locations for NP_001165365.1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417, A8K720
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    5. NM_001319206.4 → NP_001306135.1  myocyte-specific enhancer factor 2A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS81920.1
      UniProtKB/TrEMBL
      A0A0S2Z4N0, A8K720
      Related
      ENSP00000453095.1, ENST00000557942.6
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 150
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    6. NM_001352614.4 → NP_001339543.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417, A8K720
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    7. NM_001352615.4 → NP_001339544.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417, A8K720
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    8. NM_001352616.4 → NP_001339545.1  myocyte-specific enhancer factor 2A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS81920.1
      UniProtKB/TrEMBL
      A0A0S2Z4N0, A8K720
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 150
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    9. NM_001352617.4 → NP_001339546.1  myocyte-specific enhancer factor 2A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45362.1
      UniProtKB/TrEMBL
      A0A0S2Z454, A8K720
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    10. NM_001352618.4 → NP_001339547.1  myocyte-specific enhancer factor 2A isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      UniProtKB/TrEMBL
      A8K720
      Related
      ENSP00000508747.1, ENST00000685785.1
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 156
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    11. NM_001365201.3 → NP_001352130.1  myocyte-specific enhancer factor 2A isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS92068.1
      UniProtKB/TrEMBL
      A0A8I5KVQ4, A8K720
      Related
      ENSP00000337202.8, ENST00000338042.11
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 156
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    12. NM_001365202.3 → NP_001352131.1  myocyte-specific enhancer factor 2A isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS92068.1
      UniProtKB/TrEMBL
      A0A8I5KVQ4, A8K720
      Related
      ENSP00000509700.1, ENST00000690055.1
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 156
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    13. NM_001365203.3 → NP_001352132.1  myocyte-specific enhancer factor 2A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS92067.1
      UniProtKB/Swiss-Prot
      B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
      UniProtKB/TrEMBL
      A0A0S2Z453, A8K720
      Related
      ENSP00000509137.1, ENST00000686611.1
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    14. NM_001365204.3 → NP_001352133.1  myocyte-specific enhancer factor 2A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS92067.1
      UniProtKB/Swiss-Prot
      B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
      UniProtKB/TrEMBL
      A0A0S2Z453, A8K720
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    15. NM_001365205.3 → NP_001352134.1  myocyte-specific enhancer factor 2A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS81920.1
      UniProtKB/TrEMBL
      A0A0S2Z4N0, A8K720
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 150
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    16. NM_001365206.3 → NP_001352135.1  myocyte-specific enhancer factor 2A isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      UniProtKB/TrEMBL
      A8K720
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 156
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    17. NM_001365207.3 → NP_001352136.1  myocyte-specific enhancer factor 2A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45362.1
      UniProtKB/TrEMBL
      A0A0S2Z454, A8K720
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    18. NM_001365208.3 → NP_001352137.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417, A8K720
      Related
      ENSP00000453441.1, ENST00000557785.5
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    19. NM_001365209.3 → NP_001352138.1  myocyte-specific enhancer factor 2A isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45363.1
      UniProtKB/TrEMBL
      A8K720
      Conserved Domains (2) summary
      pfam12347
      Location:29 → 82
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
      cl00109
      Location:2 → 25
      MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...

    20. NM_001365210.2 → NP_001352139.1  myocyte-specific enhancer factor 2A isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    21. NM_001365211.2 → NP_001352140.1  myocyte-specific enhancer factor 2A isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 150
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    22. NM_001393558.2 → NP_001380487.1  myocyte-specific enhancer factor 2A isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      UniProtKB/TrEMBL
      A8K720
      Conserved Domains (1) summary
      pfam12347
      Location:29 → 83
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    23. NM_001393559.2 → NP_001380488.1  myocyte-specific enhancer factor 2A isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS58401.1
      UniProtKB/TrEMBL
      A0A0S2Z4C8, A8K720
      Conserved Domains (2) summary
      pfam12347
      Location:29 → 81
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
      cl00109
      Location:2 → 25
      MADS; MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type ...

    24. NM_001393560.2 → NP_001380489.1  myocyte-specific enhancer factor 2A isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Conserved Domains (2) summary
      COG5068
      Location:1 → 309
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    25. NM_001393561.3 → NP_001380490.1  myocyte-specific enhancer factor 2A isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Conserved Domains (1) summary
      cl00109
      Location:2 → 20
      MADS; MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type ...

    26. NM_001400028.1 → NP_001386957.1  myocyte-specific enhancer factor 2A isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967

    27. NM_001400029.1 → NP_001386958.1  myocyte-specific enhancer factor 2A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS92067.1
      UniProtKB/Swiss-Prot
      B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
      UniProtKB/TrEMBL
      A0A0S2Z453

    28. NM_001400030.1 → NP_001386959.1  myocyte-specific enhancer factor 2A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS92067.1
      UniProtKB/Swiss-Prot
      B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
      UniProtKB/TrEMBL
      A0A0S2Z453

    29. NM_001400031.1 → NP_001386960.1  myocyte-specific enhancer factor 2A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS81920.1
      UniProtKB/TrEMBL
      A0A0S2Z4N0

    30. NM_001400032.1 → NP_001386961.1  myocyte-specific enhancer factor 2A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS81920.1
      UniProtKB/TrEMBL
      A0A0S2Z4N0

    31. NM_001400033.1 → NP_001386962.1  myocyte-specific enhancer factor 2A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS81920.1
      UniProtKB/TrEMBL
      A0A0S2Z4N0

    32. NM_001400034.1 → NP_001386963.1  myocyte-specific enhancer factor 2A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS81920.1
      UniProtKB/TrEMBL
      A0A0S2Z4N0

    33. NM_001400035.1 → NP_001386964.1  myocyte-specific enhancer factor 2A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS81920.1
      UniProtKB/TrEMBL
      A0A0S2Z4N0

    34. NM_001400036.1 → NP_001386965.1  myocyte-specific enhancer factor 2A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS81920.1
      UniProtKB/TrEMBL
      A0A0S2Z4N0

    35. NM_001400037.1 → NP_001386966.1  myocyte-specific enhancer factor 2A isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967

    36. NM_001400038.1 → NP_001386967.1  myocyte-specific enhancer factor 2A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45362.1
      UniProtKB/TrEMBL
      A0A0S2Z454

    37. NM_001400039.1 → NP_001386968.1  myocyte-specific enhancer factor 2A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45362.1
      UniProtKB/TrEMBL
      A0A0S2Z454

    38. NM_001400040.1 → NP_001386969.1  myocyte-specific enhancer factor 2A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45362.1
      UniProtKB/TrEMBL
      A0A0S2Z454

    39. NM_001400049.1 → NP_001386978.1  myocyte-specific enhancer factor 2A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45362.1
      UniProtKB/TrEMBL
      A0A0S2Z454

    40. NM_001400050.1 → NP_001386979.1  myocyte-specific enhancer factor 2A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45362.1
      UniProtKB/TrEMBL
      A0A0S2Z454

    41. NM_001400051.1 → NP_001386980.1  myocyte-specific enhancer factor 2A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45362.1
      UniProtKB/TrEMBL
      A0A0S2Z454

    42. NM_001400052.1 → NP_001386981.1  myocyte-specific enhancer factor 2A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45362.1
      UniProtKB/TrEMBL
      A0A0S2Z454

    43. NM_001400053.1 → NP_001386982.1  myocyte-specific enhancer factor 2A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45362.1
      UniProtKB/TrEMBL
      A0A0S2Z454

    44. NM_001400054.1 → NP_001386983.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    45. NM_001400055.1 → NP_001386984.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    46. NM_001400056.1 → NP_001386985.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    47. NM_001400057.1 → NP_001386986.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    48. NM_001400058.1 → NP_001386987.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    49. NM_001400059.1 → NP_001386988.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    50. NM_001400060.1 → NP_001386989.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    51. NM_001400061.1 → NP_001386990.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    52. NM_001400062.1 → NP_001386991.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    53. NM_001400063.1 → NP_001386992.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    54. NM_001400064.1 → NP_001386993.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    55. NM_001400065.1 → NP_001386994.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    56. NM_001400066.1 → NP_001386995.1  myocyte-specific enhancer factor 2A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS53978.1
      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    57. NM_001400067.1 → NP_001386996.1  myocyte-specific enhancer factor 2A isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967

    58. NM_001400068.1 → NP_001386997.1  myocyte-specific enhancer factor 2A isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967

    59. NM_001400069.1 → NP_001386998.1  myocyte-specific enhancer factor 2A isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967

    60. NM_001400070.1 → NP_001386999.1  myocyte-specific enhancer factor 2A isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967

    61. NM_001400071.1 → NP_001387000.1  myocyte-specific enhancer factor 2A isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967

    62. NM_005587.6 → NP_005578.2  myocyte-specific enhancer factor 2A isoform 1

      See identical proteins and their annotated locations for NP_005578.2

      Status: REVIEWED

      Source sequence(s)
      AC022692, AC103967
      Consensus CDS
      CCDS45362.1
      UniProtKB/TrEMBL
      A0A0S2Z454, A8K720
      Related
      ENSP00000346389.5, ENST00000354410.9
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      99565417..99716488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521572.3 → XP_011519874.1  myocyte-specific enhancer factor 2A isoform X1

      See identical proteins and their annotated locations for XP_011519874.1

      UniProtKB/TrEMBL
      A0A8I5KVQ4, A8K720
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 156
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    2. XM_011521579.3 → XP_011519881.1  myocyte-specific enhancer factor 2A isoform X1

      See identical proteins and their annotated locations for XP_011519881.1

      UniProtKB/TrEMBL
      A0A8I5KVQ4, A8K720
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 156
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    3. XM_047432530.1 → XP_047288486.1  myocyte-specific enhancer factor 2A isoform X6

      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    4. XM_047432531.1 → XP_047288487.1  myocyte-specific enhancer factor 2A isoform X6

      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    5. XM_047432528.1 → XP_047288484.1  myocyte-specific enhancer factor 2A isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z454

    6. XM_011521582.3 → XP_011519884.1  myocyte-specific enhancer factor 2A isoform X2

      See identical proteins and their annotated locations for XP_011519884.1

      UniProtKB/Swiss-Prot
      B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
      UniProtKB/TrEMBL
      A0A0S2Z453, A8K720
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    7. XM_047432520.1 → XP_047288476.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVQ4

    8. XM_047432523.1 → XP_047288479.1  myocyte-specific enhancer factor 2A isoform X4

    9. XM_047432521.1 → XP_047288477.1  myocyte-specific enhancer factor 2A isoform X2

      UniProtKB/Swiss-Prot
      B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
      UniProtKB/TrEMBL
      A0A0S2Z453

    10. XM_047432529.1 → XP_047288485.1  myocyte-specific enhancer factor 2A isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z454

    11. XM_011521585.3 → XP_011519887.1  myocyte-specific enhancer factor 2A isoform X7

      UniProtKB/TrEMBL
      A8K720
      Conserved Domains (2) summary
      pfam12347
      Location:30 → 88
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
      cl00109
      Location:2 → 18
      MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...

    12. XM_047432532.1 → XP_047288488.1  myocyte-specific enhancer factor 2A isoform X8

    13. XM_011521573.3 → XP_011519875.1  myocyte-specific enhancer factor 2A isoform X1

      See identical proteins and their annotated locations for XP_011519875.1

      UniProtKB/TrEMBL
      A0A8I5KVQ4, A8K720
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 156
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    14. XM_047432527.1 → XP_047288483.1  myocyte-specific enhancer factor 2A isoform X4

    15. XM_047432519.1 → XP_047288475.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVQ4

    16. XM_047432526.1 → XP_047288482.1  myocyte-specific enhancer factor 2A isoform X2

      UniProtKB/Swiss-Prot
      B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
      UniProtKB/TrEMBL
      A0A0S2Z453

    17. XM_047432522.1 → XP_047288478.1  myocyte-specific enhancer factor 2A isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z4N0

    18. XM_047432525.1 → XP_047288481.1  myocyte-specific enhancer factor 2A isoform X6

      UniProtKB/TrEMBL
      A0A0S2Z417
      Conserved Domains (2) summary
      COG5068
      Location:1 → 235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

    19. XM_011521577.3 → XP_011519879.1  myocyte-specific enhancer factor 2A isoform X1

      See identical proteins and their annotated locations for XP_011519879.1

      UniProtKB/TrEMBL
      A0A8I5KVQ4, A8K720
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 156
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    20. XM_047432524.1 → XP_047288480.1  myocyte-specific enhancer factor 2A isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z454

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      97329154..97480250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377935.1 → XP_054233910.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVQ4

    2. XM_054377938.1 → XP_054233913.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVQ4

    3. XM_054377951.1 → XP_054233926.1  myocyte-specific enhancer factor 2A isoform X6

      UniProtKB/TrEMBL
      A0A0S2Z417

    4. XM_054377952.1 → XP_054233927.1  myocyte-specific enhancer factor 2A isoform X6

      UniProtKB/TrEMBL
      A0A0S2Z417

    5. XM_054377949.1 → XP_054233924.1  myocyte-specific enhancer factor 2A isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z454

    6. XM_054377941.1 → XP_054233916.1  myocyte-specific enhancer factor 2A isoform X2

      UniProtKB/Swiss-Prot
      B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
      UniProtKB/TrEMBL
      A0A0S2Z453

    7. XM_054377940.1 → XP_054233915.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVQ4

    8. XM_054377944.1 → XP_054233919.1  myocyte-specific enhancer factor 2A isoform X4

    9. XM_054377942.1 → XP_054233917.1  myocyte-specific enhancer factor 2A isoform X2

      UniProtKB/Swiss-Prot
      B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
      UniProtKB/TrEMBL
      A0A0S2Z453

    10. XM_054377950.1 → XP_054233925.1  myocyte-specific enhancer factor 2A isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z454

    11. XM_054377953.1 → XP_054233928.1  myocyte-specific enhancer factor 2A isoform X7

    12. XM_054377954.1 → XP_054233929.1  myocyte-specific enhancer factor 2A isoform X8

    13. XM_054377936.1 → XP_054233911.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVQ4

    14. XM_054377948.1 → XP_054233923.1  myocyte-specific enhancer factor 2A isoform X4

    15. XM_054377939.1 → XP_054233914.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVQ4

    16. XM_054377947.1 → XP_054233922.1  myocyte-specific enhancer factor 2A isoform X2

      UniProtKB/Swiss-Prot
      B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
      UniProtKB/TrEMBL
      A0A0S2Z453

    17. XM_054377943.1 → XP_054233918.1  myocyte-specific enhancer factor 2A isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z4N0

    18. XM_054377946.1 → XP_054233921.1  myocyte-specific enhancer factor 2A isoform X6

      UniProtKB/TrEMBL
      A0A0S2Z417

    19. XM_054377937.1 → XP_054233912.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVQ4

    20. XM_054377945.1 → XP_054233920.1  myocyte-specific enhancer factor 2A isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z454
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02078.1 GenPept UniProtKB/Swiss-Prot:Q02078

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