SRC SRC proto-oncogene, non-receptor tyrosine kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRCprovided by HGNC
Official Full Name: SRC proto-oncogene, non-receptor tyrosine kinaseprovided by HGNC
Primary source: HGNC:HGNC:11283
See related: Ensembl:ENSG00000197122 MIM:190090; AllianceGenome:HGNC:11283
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ASV; SRC1; THC6; c-SRC; p60-Src
Summary: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in stomach (RPKM 19.0), testis (RPKM 19.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q11.23

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (37344699..37406050)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (39068774..39130114)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (35973102..36034453)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oxidative Stress Participates in Age-Related Cataract Formation by Disrupting Connection between Lens Epithelial Cells through c-Src/VEGF Pathway.
Title: Oxidative Stress Participates in Age-Related Cataract Formation by Disrupting Connection between Lens Epithelial Cells through c-Src/VEGF Pathway.
ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.
Title: ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.
Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression.
Title: Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression.
TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization.
Title: TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization.
c-Src regulates delta-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6.
Title: c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6.
Compartment-specific multiomic profiling identifies SRC and GNAS as candidate drivers of epithelial-to-mesenchymal transition in ovarian carcinosarcoma.
Title: Compartment-specific multiomic profiling identifies SRC and GNAS as candidate drivers of epithelial-to-mesenchymal transition in ovarian carcinosarcoma.
An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function.
Title: An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function.
Identification and functional validation of SRC and RAPGEF1 as new direct targets of miR-203, involved in regulation of epidermal homeostasis.
Title: Identification and functional validation of SRC and RAPGEF1 as new direct targets of miR-203, involved in regulation of epidermal homeostasis.
The activated CD36-Src axis promotes lung adenocarcinoma cell proliferation and actin remodeling-involved metastasis in high-fat environment.
Title: The activated CD36-Src axis promotes lung adenocarcinoma cell proliferation and actin remodeling-involved metastasis in high-fat environment.
SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway.
Title: SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (735)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Colorectal cancer MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome	Compare labs
Thrombocytopenia 6 MedGen: C4310789 OMIM: 616937 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide association study of retinopathy in individuals without diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 activates SRC in monocyte derived dendritic cells	PubMed
Knockdown of c-SRC tyrosine kinase by siRNA enhances HIV-1 infectivity in Jurkat cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells	PubMed
	env	Interaction of SLIT2 with Robo4 significantly inhibits HIV-1 gp120-induced phosphorylation of c-Src in human lymphatic endothelial cells	PubMed
Nef	nef	Activation and translocation of Src kinase is critical for Nef-mediated CD80 and CD86 internalization	PubMed
	nef	HIV-1 Nef-mediated downregulation of MHC-I requires Nef motif EEEE(65)-dependent binding to the sorting protein PACS-2, which targets Nef to the paranuclear region and enables Nef PXXP(75) to bind and activate a trans-Golgi network localized Src kinase	PubMed
	nef	High throughput screening identifies compounds targeting the Nef SH3 binding surface and that efficiently compete for Nef-SH3 interactions	PubMed
	nef	HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner	PubMed
	nef	The RT loop region (residues 90-108) in the Src SH3 domain binds to HIV-1 Nef, but this binding is looser than that of the Hck SH3 domain to HIV-1 Nef	PubMed
Tat	tat	HIV-1 Tat increases permeability of human glomerular endothelial cells by activating Rho-A, pMLC, and c-Src pathways, which involves VEGF-A or FGF-2.	PubMed
	tat	HIV-1 Tat stimulates the tyrosine phosphorylation and activation of c-Src kinase resulting in the activation of the intrinsic kinase activity of c-Src, an effect associated with Tat-induced angiogenesis and Kaposi's sarcoma	PubMed
	tat	HIV-1 Tat and cocaine treatment upregulates the expreesion of phophorylated SRC protein in human pulmonary arterial smooth muscle cells	PubMed
	tat	HIV-1 Tat potentiates NMDA-evoked (Ca2+)I responses involve LRP and a Src family kinase via the NOS/sGC/PKG pathway	PubMed
	tat	Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes	PubMed
	tat	Adhesion of endothelial cells to HIV-1 Tat triggers a signal transduction pathway, which leads to phosphorylation of VEGFR2 and pp60src and activation of ERK1/2	PubMed
	tat	HIV-1 Tat inhibits autophagy in bystander macrophages/monocytic cells through Tat-mediated activation and phosphorylation of Src-Akt signaling	PubMed
	tat	HIV-1 Tat treatment of human neurons results in tyrosine (Y) phosphorylation at position 1325 of the NMDAR subunit 2A (NR2A) in a src kinase-dependent manner	PubMed
	tat	HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src	PubMed
reverse transcriptase	gag-pol	Knockdown of c-Src or Pyk2 by siRNA followed by HIV-1 infection in Jurkat T-cells leads to increased reverse transcriptase activity, viral cDNA, and integrated viral genome, suggesting that c-Src and PYK2 interact with HIV-1 RT	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SRC_1807 (e-PCR)
- UniSTS:277768

SRC (e-PCR)
- UniSTS:266007

SHGC-132356 (e-PCR)
- UniSTS:170791

RH98828 (e-PCR)
- UniSTS:87438

NoName (e-PCR)
- UniSTS:7066

Z94309 (e-PCR)
- UniSTS:7836

D20S570E (e-PCR)
- UniSTS:38822

RH12300 (e-PCR)
- UniSTS:65458

D20S834 (e-PCR), detects polymorphism
- UniSTS:79302

WI-14593 (e-PCR)
- UniSTS:44757

PMC115282P1 (e-PCR)
- UniSTS:270298

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISS Inferred from Sequence or Structural Similarity more info
enables BMP receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables SH2 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables connexin binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	TAS Traceable Author Statement more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables phospholipase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ERBB2 signaling pathway	TAS Traceable Author Statement more info
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis	TAS Traceable Author Statement more info
involved_in T cell costimulation	TAS Traceable Author Statement more info
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info
involved_in angiotensin-activated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone resorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in branching involved in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fatty acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fluid shear stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to peptide hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to platelet-derived growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to progesterone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to prolactin	IEA Inferred from Electronic Annotation more info
involved_in entry of bacterium into host cell	TAS Traceable Author Statement more info
involved_in ephrin receptor signaling pathway	TAS Traceable Author Statement more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	TAS Traceable Author Statement more info
involved_in focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain development	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-6-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intestinal epithelial cell development	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in learning or memory	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration	TAS Traceable Author Statement more info
involved_in macroautophagy	TAS Traceable Author Statement more info
involved_in myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of anoikis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response to antigenic stimulus	TAS Traceable Author Statement more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of telomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotrophin TRK receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in odontogenesis	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	NAS Non-traceable Author Statement more info	PubMed
involved_in platelet activation	TAS Traceable Author Statement more info
involved_in platelet-derived growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone resorption	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of integrin activation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of lamellipodium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of male germ cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-membrane spanning protein tyrosine kinase activity	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of ovarian follicle development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS Traceable Author Statement more info
involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of podosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of small GTPase mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in primary ovarian follicle growth	IEA Inferred from Electronic Annotation more info
involved_in progesterone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in progesterone receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein destabilization	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of bone resorption	TAS Traceable Author Statement more info	PubMed
involved_in regulation of caveolin-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell projection assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of early endosome to late endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate by cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of intracellular estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of toll-like receptor 3 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of vascular permeability	TAS Traceable Author Statement more info	PubMed
involved_in response to acidic pH	IEA Inferred from Electronic Annotation more info
involved_in response to electrical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to interleukin-1	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to mineralocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal complex assembly	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in skeletal muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in stimulatory C-type lectin receptor signaling pathway	TAS Traceable Author Statement more info
involved_in stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in transcytosis	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in uterus development	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	IDA Inferred from Direct Assay more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic filopodium	IEA Inferred from Electronic Annotation more info
located_in dendritic growth cone	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in podosome	IEA Inferred from Electronic Annotation more info
located_in postsynaptic specialization, intracellular component	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proto-oncogene tyrosine-protein kinase Src

Names: proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

NP_005408.1

EC 2.7.10.2

NP_938033.1

EC 2.7.10.2

XP_016883515.1

EC 2.7.10.2

XP_047296352.1

EC 2.7.10.2

XP_047296353.1

EC 2.7.10.2

XP_047296354.1

EC 2.7.10.2

XP_047296355.1

EC 2.7.10.2

XP_047296356.1

EC 2.7.10.2

XP_047296357.1

EC 2.7.10.2

XP_047296358.1

EC 2.7.10.2

XP_047296359.1

EC 2.7.10.2

XP_047296360.1

EC 2.7.10.2

XP_047296361.1

EC 2.7.10.2

XP_047296362.1

EC 2.7.10.2

XP_047296363.1

EC 2.7.10.2

XP_047296364.1

EC 2.7.10.2

XP_047296365.1

EC 2.7.10.2

XP_047296366.1

EC 2.7.10.2

XP_047296367.1

EC 2.7.10.2

XP_047296368.1

EC 2.7.10.2

XP_047296369.1

EC 2.7.10.2

XP_054179874.1

EC 2.7.10.2

XP_054179875.1

EC 2.7.10.2

XP_054179876.1

EC 2.7.10.2

XP_054179877.1

EC 2.7.10.2

XP_054179878.1

EC 2.7.10.2

XP_054179879.1

EC 2.7.10.2

XP_054179880.1

EC 2.7.10.2

XP_054179881.1

EC 2.7.10.2

XP_054179882.1

EC 2.7.10.2

XP_054179883.1

EC 2.7.10.2

XP_054179884.1

EC 2.7.10.2

XP_054179885.1

EC 2.7.10.2

XP_054179886.1

EC 2.7.10.2

XP_054179887.1

EC 2.7.10.2

XP_054179888.1

EC 2.7.10.2

XP_054179889.1

EC 2.7.10.2

XP_054179890.1

EC 2.7.10.2

XP_054179891.1

EC 2.7.10.2

XP_054179892.1

EC 2.7.10.2

XP_054189256.1

EC 2.7.10.2

XP_054189257.1

EC 2.7.10.2

XP_054189258.1

EC 2.7.10.2

XP_054189259.1

EC 2.7.10.2

XP_054189260.1

EC 2.7.10.2

XP_054189261.1

EC 2.7.10.2

XP_054189262.1

EC 2.7.10.2

XP_054189263.1

EC 2.7.10.2

XP_054189264.1

EC 2.7.10.2

XP_054189265.1

EC 2.7.10.2

XP_054189266.1

EC 2.7.10.2

XP_054189267.1

EC 2.7.10.2

XP_054189268.1

EC 2.7.10.2

XP_054189269.1

EC 2.7.10.2

XP_054189270.1

EC 2.7.10.2

XP_054189271.1

EC 2.7.10.2

XP_054189272.1

EC 2.7.10.2

XP_054189273.1

EC 2.7.10.2

XP_054189274.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023033.1 RefSeqGene

Range

6444..65748

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1018

mRNA and Protein(s)

NM_005417.5 → NP_005408.1 proto-oncogene tyrosine-protein kinase Src

See identical proteins and their annotated locations for NP_005408.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AL034422, AL133293, KF456893

Consensus CDS

CCDS13294.1

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8

Conserved Domains (3) summary

cd10365
Location:147 → 247

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 143

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:260 → 536

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
NM_198291.3 → NP_938033.1 proto-oncogene tyrosine-protein kinase Src

See identical proteins and their annotated locations for NP_938033.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AL133293, AW135290, BC051270, CD364525, HY016645

Consensus CDS

CCDS13294.1

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8

Related

ENSP00000362680.2, ENST00000373578.7

Conserved Domains (3) summary

cd10365
Location:147 → 247

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 143

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:260 → 536

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

37344699..37406050

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047440399.1 → XP_047296355.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_047440400.1 → XP_047296356.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_047440407.1 → XP_047296363.1 proto-oncogene tyrosine-protein kinase Src isoform X3
XM_047440396.1 → XP_047296352.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_047440402.1 → XP_047296358.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_047440411.1 → XP_047296367.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_047440405.1 → XP_047296361.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_047440408.1 → XP_047296364.1 proto-oncogene tyrosine-protein kinase Src isoform X3
XM_047440397.1 → XP_047296353.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_047440401.1 → XP_047296357.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_047440410.1 → XP_047296366.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_047440406.1 → XP_047296362.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_047440398.1 → XP_047296354.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_047440403.1 → XP_047296359.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_047440413.1 → XP_047296369.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_047440409.1 → XP_047296365.1 proto-oncogene tyrosine-protein kinase Src isoform X3
XM_017028026.2 → XP_016883515.1 proto-oncogene tyrosine-protein kinase Src isoform X1

UniProtKB/Swiss-Prot

P12931

Related

ENSP00000362659.2, ENST00000373558.2

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_047440412.1 → XP_047296368.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8

Related

ENSP00000362668.2, ENST00000373567.6
XM_047440404.1 → XP_047296360.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8

Reference GRCh38.p14 PATCHES

Genomic

NW_025791812.1 Reference GRCh38.p14 PATCHES

Range

254201..315552

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333285.1 → XP_054189260.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_054333286.1 → XP_054189261.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_054333293.1 → XP_054189268.1 proto-oncogene tyrosine-protein kinase Src isoform X3
XM_054333281.1 → XP_054189256.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_054333288.1 → XP_054189263.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054333297.1 → XP_054189272.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054333291.1 → XP_054189266.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054333294.1 → XP_054189269.1 proto-oncogene tyrosine-protein kinase Src isoform X3
XM_054333282.1 → XP_054189257.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_054333287.1 → XP_054189262.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054333296.1 → XP_054189271.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054333292.1 → XP_054189267.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054333283.1 → XP_054189258.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_054333289.1 → XP_054189264.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054333299.1 → XP_054189274.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054333295.1 → XP_054189270.1 proto-oncogene tyrosine-protein kinase Src isoform X3
XM_054333284.1 → XP_054189259.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_054333298.1 → XP_054189273.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054333290.1 → XP_054189265.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8

Alternate T2T-CHM13v2.0

Genomic

NC_060944.1 Alternate T2T-CHM13v2.0

Range

39068774..39130114

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054323903.1 → XP_054179878.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_054323904.1 → XP_054179879.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_054323911.1 → XP_054179886.1 proto-oncogene tyrosine-protein kinase Src isoform X3
XM_054323899.1 → XP_054179874.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_054323906.1 → XP_054179881.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054323915.1 → XP_054179890.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054323909.1 → XP_054179884.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054323912.1 → XP_054179887.1 proto-oncogene tyrosine-protein kinase Src isoform X3
XM_054323900.1 → XP_054179875.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_054323905.1 → XP_054179880.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054323914.1 → XP_054179889.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054323910.1 → XP_054179885.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054323901.1 → XP_054179876.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_054323907.1 → XP_054179882.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054323917.1 → XP_054179892.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054323913.1 → XP_054179888.1 proto-oncogene tyrosine-protein kinase Src isoform X3
XM_054323902.1 → XP_054179877.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_054323916.1 → XP_054179891.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
XM_054323908.1 → XP_054179883.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8