RAB9A RAB9A, member RAS oncogene family [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB9Aprovided by HGNC
Official Full Name: RAB9A, member RAS oncogene familyprovided by HGNC
Primary source: HGNC:HGNC:9792
See related: Ensembl:ENSG00000123595 MIM:300284; AllianceGenome:HGNC:9792
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAB9
Summary: Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in negative regulation by host of symbiont catalytic activity; positive regulation of exocytosis; and regulation of protein localization. Located in late endosome; lysosome; and phagocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal (RPKM 21.5), bone marrow (RPKM 11.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xp22.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (13689128..13710504)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (13270511..13291900)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (13707247..13728623)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Noncanonical Rab9a action supports retromer-mediated endosomal exit of human papillomavirus during virus entry.
Title: Noncanonical Rab9a action supports retromer-mediated endosomal exit of human papillomavirus during virus entry.
Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.
Title: Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.
Loss of androgen receptor promotes HCC invasion and metastasis via activating circ-LNPEP/miR-532-3p/RAB9A signal under hypoxia.
Title: Loss of androgen receptor promotes HCC invasion and metastasis via activating circ-LNPEP/miR-532-3p/RAB9A signal under hypoxia.
RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells.
Title: RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells.
Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
Title: Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
Authors predicted the binding between RAB9A and miR-150-5p, and the direct interaction between RAB9A and miR-150-5p was confirmed by luciferase reporter and RNA immunoprecipitation assays. We also showed that RAB9A expression was regulated negatively by miR-150-5p, but was regulated positively by ZFAS1.
Title: Long noncoding RNA ZFAS1 promotes tumorigenesis through regulation of miR-150-5p/RAB9A in melanoma.
RAB9 competes with the catalytic subunit PPP2CA in binding to PPP2R1A. This competitive association has an important role in controlling the PP2A catalytic activity.
Title: A subset of RAB proteins modulates PP2A phosphatase activity.
protein kinase C modulates alpha1B-adrenergic receptor transfer to late endosomes and that Rab9 regulates this process and participates in G protein-mediated signaling turn-off.
Title: Protein Kinase C Activation Promotes α(1B)-Adrenoceptor Internalization and Late Endosome Trafficking through Rab9 Interaction. Role in Heterologous Desensitization.
Rab9A and its co-regulatory GTPases control STX13-mediated cargo delivery to maturing melanosomes.
Title: Rab9A is required for delivery of cargo from recycling endosomes to melanosomes.
Rab9-complexed TIP47 plays an essential role for the proper release of hepatitis C viral particles.
Title: TIP47 is associated with the hepatitis C virus and its interaction with Rab9 is required for release of viral particles.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of RAB9A, member RAS oncogene family (RAB9A) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef disrupts Rab9-GCC2 interaction (in HEK-293 cells) resulting in delocalization of CI-MPR resulting in elevated secretion of hexosaminidase in HEK-293 cells	PubMed
Pr55(Gag)	gag	HIV-1 Gag co-localizes with Rab9 and TGN38 in endosomes and trans-Golgi compartments	PubMed
	gag	HIV-1 Gag co-localizes with Rab7-, Rab9-, and LAMP1-containing membranes at cytoplasmic and juxtanuclear sites in Staufen1-depleted cells	PubMed
	gag	Depletion of Rab9 by siRNA sequesters HIV-1 Gag within cells and causes a reduction in particle release	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-37e4 (e-PCR)
- UniSTS:258391

RAB9A_1416 (e-PCR)
- UniSTS:277650

RAB9A_v466 (e-PCR)
- UniSTS:277650

STS-R66378 (e-PCR)
- UniSTS:41894

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation by host of symbiont catalytic activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in melanosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in phagocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	TAS Traceable Author Statement more info
located_in transport vesicle	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ras-related protein Rab-9A

Names: RAB9, member RAS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195328.2 → NP_001182257.1 ras-related protein Rab-9A

See identical proteins and their annotated locations for NP_001182257.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC003037, AK290505, BC017265, CF528703, DA141710

Consensus CDS

CCDS14156.1

UniProtKB/Swiss-Prot

A8K390, P51151, Q6ICN1

Related

ENSP00000480777.1, ENST00000618931.2

Conserved Domains (1) summary

cd04116
Location:3 → 172

Rab9; Rab GTPase family 9 (Rab9)
NM_004251.5 → NP_004242.1 ras-related protein Rab-9A

See identical proteins and their annotated locations for NP_004242.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC003037, BC017265, CF528703, DA141710

Consensus CDS

CCDS14156.1

UniProtKB/Swiss-Prot

A8K390, P51151, Q6ICN1

Related

ENSP00000420127.1, ENST00000464506.2

Conserved Domains (1) summary

cd04116
Location:3 → 172

Rab9; Rab GTPase family 9 (Rab9)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

13689128..13710504

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047442645.1 → XP_047298601.1 ras-related protein Rab-9A isoform X1

UniProtKB/Swiss-Prot

A8K390, P51151, Q6ICN1
XM_047442644.1 → XP_047298600.1 ras-related protein Rab-9A isoform X1

UniProtKB/Swiss-Prot

A8K390, P51151, Q6ICN1

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

13270511..13291900

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054328136.1 → XP_054184111.1 ras-related protein Rab-9A isoform X1

UniProtKB/Swiss-Prot

A8K390, P51151, Q6ICN1
XM_054328135.1 → XP_054184110.1 ras-related protein Rab-9A isoform X1

UniProtKB/Swiss-Prot

A8K390, P51151, Q6ICN1