PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing [Homo sapiens (human)] - Gene

Summary

Official Symbol: PIKFYVEprovided by HGNC
Official Full Name: phosphoinositide kinase, FYVE-type zinc finger containingprovided by HGNC
Primary source: HGNC:HGNC:23785
See related: Ensembl:ENSG00000115020 MIM:609414; AllianceGenome:HGNC:23785
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CFD; FAB1; HEL37; PIP5K; PIP5K3; ZFYVE29
Summary: Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. The protein plays a key role in cell entry of ebola virus and SARS-CoV-2 by endocytosis Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. [provided by RefSeq, Jul 2021]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression: Ubiquitous expression in bone marrow (RPKM 9.7), lymph node (RPKM 8.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q34

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (208266056..208358746)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (208744537..208838556)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (209130979..209223470)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases.
Title: PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases.
PIKfyve-Dependent Phosphoinositide Dynamics in Megakaryocyte/Platelet Granule Integrity and Platelet Functions.
Title: PIKfyve-Dependent Phosphoinositide Dynamics in Megakaryocyte/Platelet Granule Integrity and Platelet Functions.
Autophagy Inhibition by Targeting PIKfyve Potentiates Response to Immune Checkpoint Blockade in Prostate Cancer.
Title: Autophagy Inhibition by Targeting PIKfyve Potentiates Response to Immune Checkpoint Blockade in Prostate Cancer.
AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation.
Title: AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation.
Disruption of PIKFYVE causes congenital cataract in human and zebrafish.
Title: Disruption of PIKFYVE causes congenital cataract in human and zebrafish.
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.
Title: Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.
Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2.
Title: Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2.
PIKfyve inhibition leads to impaired degradative capacity, ion dysregulation, abated autophagic flux and a massive enlargement of lysosomes.
Title: Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence.
this study shows that PIKfyve coordinates the neutrophil immune response through the activation of the Rac GTPase
Title: The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase.
in PC-3 cells inhibition of PIKfyve by apilimod or depletion by siRNA increased the secretion of the exosomal fraction.
Title: PIKfyve inhibition increases exosome release and induces secretory autophagy.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Fleck corneal dystrophy MedGen: C1562113 OMIM: 121850 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Overexpression of phosphatidylinositol 4 phosphate 5-kinase (PIP5K) suppresses HIV-1 Tat-mediated inhibition of growth hormone secretion from cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2S1317 (e-PCR)
- UniSTS:41737

D2S2289 (e-PCR), detects polymorphism
- UniSTS:61477

RH16641 (e-PCR)
- UniSTS:41257

RH120259 (e-PCR)
- UniSTS:132715

D2S325 (e-PCR), detects polymorphism
- UniSTS:14192

RH123501 (e-PCR)
- UniSTS:135876

A005D48 (e-PCR)
- UniSTS:28613

GDB:386618 (e-PCR)
- UniSTS:157149

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	TAS Traceable Author Statement more info	PubMed
enables 1-phosphatidylinositol-5-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-5-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-5-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in melanosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanosome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in myelin assembly	IEA Inferred from Electronic Annotation more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagosome maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in phagosome-lysosome fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagosome-lysosome fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol 5-phosphate metabolic process	IC Inferred by Curator more info	PubMed
involved_in phosphatidylinositol 5-phosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol biosynthetic process	TAS Traceable Author Statement more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis of virus by host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of reactive oxygen species biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of reactive oxygen species biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retrograde transport, endosome to Golgi	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	TAS Traceable Author Statement more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	TAS Traceable Author Statement more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 1-phosphatidylinositol 3-phosphate 5-kinase

Names: PIPkin-III; epididymis luminal protein 37; phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; serine-protein kinase PIKFYVE; type III PIP kinase; zinc finger, FYVE domain containing 29

NP_001171471.1

EC 2.7.1.150

EC 2.7.11.1

NP_055855.2

EC 2.7.1.150

EC 2.7.11.1

NP_689884.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509080.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509081.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509082.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509083.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509084.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509085.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509086.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509087.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509088.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509089.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509090.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509091.1

EC 2.7.1.150

EC 2.7.11.1

XP_011509094.1

EC 2.7.1.150

EC 2.7.11.1

XP_016859057.1

EC 2.7.1.150

EC 2.7.11.1

XP_016859058.1

EC 2.7.1.150

EC 2.7.11.1

XP_016859059.1

EC 2.7.1.150

EC 2.7.11.1

XP_016859060.1

EC 2.7.1.150

EC 2.7.11.1

XP_016859063.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299623.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299626.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299627.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299628.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299629.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299630.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299632.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299633.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299635.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299636.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299637.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299638.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299642.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299643.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299645.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299646.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299651.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299652.1

EC 2.7.1.150

EC 2.7.11.1

XP_047299654.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196941.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196942.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196943.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196944.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196945.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196946.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196947.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196948.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196949.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196950.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196951.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196952.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196953.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196954.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196955.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196956.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196957.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196958.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196959.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196960.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196961.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196962.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196963.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196964.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196965.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196966.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196967.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196968.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196969.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196970.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196971.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196972.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196973.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196974.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196975.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196976.1

EC 2.7.1.150

EC 2.7.11.1

XP_054196977.1

EC 2.7.1.150

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_021188.2 RefSeqGene

Range

5201..97692

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178000.2 → NP_001171471.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform 4

See identical proteins and their annotated locations for NP_001171471.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks all of the 3' coding region and UTR, compared to variant 2. The encoded protein (isoform 4) has an identical N-terminus but a short novel C-terminus, compared to isoform 2.

Source sequence(s)

AC016697, BC032389, BC125053

Consensus CDS

CCDS54431.1

UniProtKB/Swiss-Prot

Q9Y2I7

Related

ENSP00000384356.1, ENST00000407449.5

Conserved Domains (2) summary

cd04448
Location:357 → 438

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

cd15725
Location:154 → 215

FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
NM_015040.4 → NP_055855.2 1-phosphatidylinositol 3-phosphate 5-kinase isoform 2

See identical proteins and their annotated locations for NP_055855.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).

Source sequence(s)

AC012362, AC016697

Consensus CDS

CCDS2382.1

UniProtKB/Swiss-Prot

Q08AR7, Q08AR8, Q53ST3, Q53T36, Q8N5H0, Q8NB67, Q9Y2I7

Related

ENSP00000264380.4, ENST00000264380.9

Conserved Domains (4) summary

cd00139
Location:1772 → 2085

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:617 → 877

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:357 → 438

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

cd15725
Location:154 → 215

FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
NM_152671.4 → NP_689884.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform 3

See identical proteins and their annotated locations for NP_689884.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two in-frame exons in the 5' coding region and all of the 3' coding region and UTR, compared to variant 2. The encoded protein (isoform 3) has a shorter N-terminus and a short novel C-terminus, compared to isoform 2.

Source sequence(s)

AC016697, BC032389

Consensus CDS

CCDS33368.1

UniProtKB/Swiss-Prot

Q9Y2I7

Related

ENSP00000376038.3, ENST00000392202.7

Conserved Domains (1) summary

cd04448
Location:260 → 341

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

208266056..208358746

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011510779.3 → XP_011509081.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

See identical proteins and their annotated locations for XP_011509081.1

Conserved Domains (4) summary

cd00139
Location:1784 → 2097

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:629 → 889

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:369 → 450

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

cd15725
Location:166 → 227

FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
XM_047443667.1 → XP_047299623.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

UniProtKB/Swiss-Prot

Q08AR7, Q08AR8, Q53ST3, Q53T36, Q8N5H0, Q8NB67, Q9Y2I7
XM_047443672.1 → XP_047299628.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X11
XM_047443674.1 → XP_047299630.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X16
XM_011510778.4 → XP_011509080.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

See identical proteins and their annotated locations for XP_011509080.1

Conserved Domains (4) summary

cd00139
Location:1784 → 2097

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:629 → 889

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:369 → 450

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

cd15725
Location:166 → 227

FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
XM_011510782.4 → XP_011509084.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X6

Conserved Domains (4) summary

cd00139
Location:1735 → 2042

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:629 → 889

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:369 → 450

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

cd15725
Location:166 → 227

FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
XM_011510783.4 → XP_011509085.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X7

Conserved Domains (4) summary

cd00139
Location:1728 → 2041

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:573 → 833

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:369 → 450

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

cd15725
Location:166 → 227

FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
XM_011510781.4 → XP_011509083.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

Conserved Domains (4) summary

cd00139
Location:1778 → 2091

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:623 → 883

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:369 → 450

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

cd15725
Location:166 → 227

FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
XM_011510785.4 → XP_011509087.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X9

Conserved Domains (4) summary

cd00139
Location:1722 → 2035

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:567 → 827

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:369 → 450

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

cd15725
Location:166 → 227

FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
XM_011510786.4 → XP_011509088.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X14

Conserved Domains (3) summary

cd00139
Location:1687 → 2000

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:532 → 792

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:272 → 353

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
XM_047443680.1 → XP_047299636.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X20
XM_011510780.3 → XP_011509082.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

Conserved Domains (4) summary

cd00139
Location:1783 → 2096

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:628 → 888

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:368 → 449

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

cd15725
Location:165 → 226

FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
XM_011510784.3 → XP_011509086.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X8

Conserved Domains (4) summary

cd00139
Location:1727 → 2040

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:572 → 832

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:368 → 449

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

cd15725
Location:165 → 226

FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
XM_011510787.2 → XP_011509089.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X15

Conserved Domains (3) summary

cd00139
Location:1686 → 1999

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:531 → 791

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:271 → 352

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
XM_047443670.1 → XP_047299626.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X10
XM_047443671.1 → XP_047299627.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X11
XM_047443677.1 → XP_047299633.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X18
XM_017003568.2 → XP_016859057.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X5
XM_047443673.1 → XP_047299629.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X12
XM_017003569.2 → XP_016859058.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X13
XM_047443679.1 → XP_047299635.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X19
XM_011510788.2 → XP_011509090.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X16

Conserved Domains (3) summary

cd00139
Location:1675 → 1988

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:520 → 780

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:260 → 341

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
XM_047443681.1 → XP_047299637.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X22
XM_017003570.2 → XP_016859059.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X23
XM_047443690.1 → XP_047299646.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X29
XM_047443676.1 → XP_047299632.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X17
XM_047443686.1 → XP_047299642.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X25
XM_047443687.1 → XP_047299643.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X26
XM_047443696.1 → XP_047299652.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X31
XM_011510789.3 → XP_011509091.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X21

Conserved Domains (3) summary

cd00139
Location:1625 → 1938

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:470 → 730

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:210 → 291

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
XM_047443689.1 → XP_047299645.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X27
XM_017003571.2 → XP_016859060.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X28
XM_047443682.1 → XP_047299638.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X24
XM_047443695.1 → XP_047299651.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X30
XM_011510792.4 → XP_011509094.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X33

UniProtKB/TrEMBL

E9PDH4

Related

ENSP00000405736.1, ENST00000452564.1

Conserved Domains (3) summary

cd03334
Location:629 → 889

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:369 → 450

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

cd15725
Location:166 → 227

FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
XM_017003574.2 → XP_016859063.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X32

Conserved Domains (3) summary

cd00139
Location:1453 → 1766

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cd03334
Location:298 → 558

Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...

cd04448
Location:38 → 119

DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
XM_047443698.1 → XP_047299654.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X32

RNA

XR_007070607.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

208744537..208838556

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054340970.1 → XP_054196945.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

UniProtKB/TrEMBL

V9HWG4
XM_054340978.1 → XP_054196953.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X11
XM_054340967.1 → XP_054196942.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1
XM_054340984.1 → XP_054196959.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X16
XM_054340966.1 → XP_054196941.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1
XM_054340972.1 → XP_054196947.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X6
XM_054340973.1 → XP_054196948.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X7
XM_054340969.1 → XP_054196944.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X3
XM_054340975.1 → XP_054196950.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X9
XM_054340981.1 → XP_054196956.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X14
XM_054340988.1 → XP_054196963.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X20
XM_054340968.1 → XP_054196943.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X2
XM_054340974.1 → XP_054196949.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X8
XM_054340982.1 → XP_054196957.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X15
XM_054340976.1 → XP_054196951.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X10
XM_054340977.1 → XP_054196952.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X11
XM_054340986.1 → XP_054196961.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X18
XM_054340971.1 → XP_054196946.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X5
XM_054340979.1 → XP_054196954.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X12
XM_054340980.1 → XP_054196955.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X13
XM_054340987.1 → XP_054196962.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X19
XM_054340983.1 → XP_054196958.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X16
XM_054340990.1 → XP_054196965.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X22
XM_054340991.1 → XP_054196966.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X23
XM_054340997.1 → XP_054196972.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X29
XM_054340985.1 → XP_054196960.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X17
XM_054340993.1 → XP_054196968.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X25
XM_054340994.1 → XP_054196969.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X26
XM_054340999.1 → XP_054196974.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X31
XM_054340989.1 → XP_054196964.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X21
XM_054340995.1 → XP_054196970.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X27
XM_054340996.1 → XP_054196971.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X28
XM_054340992.1 → XP_054196967.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X24
XM_054340998.1 → XP_054196973.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X30
XM_054341002.1 → XP_054196977.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X33
XM_054341001.1 → XP_054196976.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X32
XM_054341000.1 → XP_054196975.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X32

RNA

XR_008486304.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001002881.1: Suppressed sequence

Description

NM_001002881.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.