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    Cap1 cyclase associated actin cytoskeleton regulatory protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 12331, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cap1provided by MGI
    Official Full Name
    cyclase associated actin cytoskeleton regulatory protein 1provided by MGI
    Primary source
    MGI:MGI:88262
    See related
    Ensembl:ENSMUSG00000028656 AllianceGenome:MGI:88262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 69.4), thymus adult (RPKM 59.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cap1 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.27 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (122752841..122779869, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (122859048..122886076, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30548 Neighboring gene STARR-seq mESC enhancer starr_11275 Neighboring gene predicted gene 12873 Neighboring gene STARR-seq mESC enhancer starr_11276 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:122504971-122505172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:122525696-122525897 Neighboring gene STARR-positive B cell enhancer ABC_E2709 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:122549318-122549471 Neighboring gene STARR-seq mESC enhancer starr_11277 Neighboring gene STARR-seq mESC enhancer starr_11278 Neighboring gene STARR-positive B cell enhancer ABC_E3510 Neighboring gene STARR-positive B cell enhancer mm9_chr4:122616319-122616620 Neighboring gene CDC28 protein kinase regulatory subunit 2 pseudogene Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin. Zhou GL, et al. J Cell Sci, 2014 Dec 1. PMID 25315833, Free PMC Article
    2. Mammalian and malaria parasite cyclase-associated proteins catalyze nucleotide exchange on G-actin through a conserved mechanism. Makkonen M, et al. J Biol Chem, 2013 Jan 11. PMID 23184938, Free PMC Article
    3. Cyclase-associated proteins: CAPacity for linking signal transduction and actin polymerization. Hubberstey AV, et al. FASEB J, 2002 Apr. PMID 11919151
    4. Glutathione alters the mode of calcium-mediated regulation of adenylyl cyclase in membranes from mouse brain. Nakamura J, et al. Biochim Biophys Acta, 1997 May 23. PMID 9187244
    5. A complex containing lysine-acetylated actin inhibits the formin INF2. A M, et al. Nat Cell Biol, 2019 May. PMID 30962575, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyclase-associated protein interacts with actin filament barbed ends to promote depolymerization and formin displacement.
      Title: Cyclase-associated protein interacts with actin filament barbed ends to promote depolymerization and formin displacement.
    2. Loss of the actin regulator cyclase-associated protein 1 (CAP1) modestly affects dendritic spine remodeling during synaptic plasticity.
      Title: Loss of the actin regulator cyclase-associated protein 1 (CAP1) modestly affects dendritic spine remodeling during synaptic plasticity.
    3. Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons.
      Title: Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons.
    4. CAP1, a target of miR-144/451, negatively regulates erythroid differentiation and enucleation.
      Title: CAP1, a target of miR-144/451, negatively regulates erythroid differentiation and enucleation.
    5. Results provide evidence for the importance of dynamic actin recycling by CAP1 and cofilin in the asymmetric division of mouse female gametes.
      Title: CAP1-mediated actin cycling via ADF/cofilin proteins is essential for asymmetric division in mouse oocytes.
    6. we purified an INF2 inhibitor from mouse brain tissue, and identified it as a complex of lysine-acetylated actin (KAc-actin) and cyclase-associated protein (CAP). Inhibition of INF2 by CAP-KAc-actin is dependent on the INF2 diaphanous inhibitory domain (DID).
      Title: A complex containing lysine-acetylated actin inhibits the formin INF2.
    7. The structural basis of actin monomer re-charging by CAP1 protein has been reported.
      Title: Structural basis of actin monomer re-charging by cyclase-associated protein.
    8. Phosphorylation regulates CAP1 function through association with cofilin and actin in order to control the actin cytoskeleton.
      Title: Phosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin.
    9. a novel inhibitory interaction between CAP1/Prss8 and nexin-1, opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity
      Title: The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition.
    10. lkj o hpoi oihl hip oihpo ih
      Title: Structure and mechanism of mouse cyclase-associated protein (CAP1) in regulating actin dynamics.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ameboidal-type cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modification of postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modification of postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenylyl cyclase-associated protein 1
    Names
    CAP, adenylate cyclase-associated protein 1
    adenylyl cyclase-associated CAP protein, yeast homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301067.2 → NP_001287996.1  adenylyl cyclase-associated protein 1

      See identical proteins and their annotated locations for NP_001287996.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a 474 aa protein. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AK053351, AK137222, AK171388, DN175073
      Consensus CDS
      CCDS18604.1
      UniProtKB/Swiss-Prot
      P40124, Q8BPT7
      UniProtKB/TrEMBL
      Q3UVJ2
      Related
      ENSMUSP00000068260.6, ENSMUST00000069533.12
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    2. NM_001358035.1 → NP_001344964.1  adenylyl cyclase-associated protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AK053351, AK137222, DN175073
      Consensus CDS
      CCDS18604.1
      UniProtKB/Swiss-Prot
      P40124, Q8BPT7
      UniProtKB/TrEMBL
      Q3UVJ2
      Related
      ENSMUSP00000101864.4, ENSMUST00000106257.10
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    3. NM_001358036.1 → NP_001344965.1  adenylyl cyclase-associated protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AK053351, AK137222, BY309560, DN175073
      Consensus CDS
      CCDS18604.1
      UniProtKB/Swiss-Prot
      P40124, Q8BPT7
      UniProtKB/TrEMBL
      Q3UVJ2
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    4. NM_007598.5 → NP_031624.2  adenylyl cyclase-associated protein 1

      See identical proteins and their annotated locations for NP_031624.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AK053351, AK137222, DN175073
      Consensus CDS
      CCDS18604.1
      UniProtKB/Swiss-Prot
      P40124, Q8BPT7
      UniProtKB/TrEMBL
      Q3UVJ2
      Related
      ENSMUSP00000101862.2, ENSMUST00000106255.8
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      122752841..122779869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40124.4 GenPept UniProtKB/Swiss-Prot:P40124

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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