SNCA synuclein alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: SNCAprovided by HGNC
Official Full Name: synuclein alphaprovided by HGNC
Primary source: HGNC:HGNC:11138
See related: Ensembl:ENSG00000145335 MIM:163890; AllianceGenome:HGNC:11138
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PD1; NACP; PARK1; PARK4
Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Expression: Biased expression in brain (RPKM 59.2), bone marrow (RPKM 24.6) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q22.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (89724099..89838304, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (93055378..93169553, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (90645250..90759455, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.
Title: Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.
Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications.
Title: Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications.
Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP.
Title: Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP.
Alpha-Synuclein and GM1 Ganglioside Co-Localize in Neuronal Cytosol Leading to Inverse Interaction-Relevance to Parkinson's Disease.
Title: Alpha-Synuclein and GM1 Ganglioside Co-Localize in Neuronal Cytosol Leading to Inverse Interaction-Relevance to Parkinson's Disease.
Peripheral Upregulation of Parkinson's Disease-Associated Genes Encoding alpha-Synuclein, beta-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression.
Title: Peripheral Upregulation of Parkinson's Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression.
Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein.
Title: Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein.
Protein-protein interactions regulating alpha-synuclein pathology.
Title: Protein-protein interactions regulating α-synuclein pathology.
Misfolded alpha-synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment.
Title: Misfolded alpha-synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment.
Molecular Behavior of alpha-Synuclein Is Associated with Membrane Transport, Lipid Metabolism, and Ubiquitin-Proteasome Pathways in Lewy Body Disease.
Title: Molecular Behavior of α-Synuclein Is Associated with Membrane Transport, Lipid Metabolism, and Ubiquitin-Proteasome Pathways in Lewy Body Disease.
Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease.
Title: Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease.

Submit: New GeneRIF Correction See all GeneRIFs (1965)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autosomal dominant Parkinson disease 1 MedGen: C1868595 OMIM: 168601 GeneReviews: Parkinson Disease Overview	Compare labs
Autosomal dominant Parkinson disease 4 MedGen: C1854182 OMIM: 605543 GeneReviews: Parkinson Disease Overview	Compare labs
Lewy body dementia MedGen: C0752347 OMIM: 127750 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. EBI GWAS Catalog EBI GWAS CatalogPubMed
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study reveals genetic risk underlying Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of a novel Parkinson's disease locus via stratified genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. EBI GWAS Catalog EBI GWAS CatalogPubMed
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A009P36 (e-PCR)
- UniSTS:58127

GDB:593720 (e-PCR)
- UniSTS:157968

GDB:593735 (e-PCR)
- UniSTS:157969

STS-R93996 (e-PCR)
- UniSTS:40469

GDB:594029 (e-PCR)
- UniSTS:157985

D4S3299 (e-PCR)
- UniSTS:16423

SHGC-50183 (e-PCR)
- UniSTS:16424

SHGC-173536 (e-PCR)
- UniSTS:185387

SHGC-59776 (e-PCR)
- UniSTS:8251

D4S2505E (e-PCR)
- UniSTS:15680

D4S3159 (e-PCR)
- UniSTS:34112

SHGC-67637 (e-PCR)
- UniSTS:69452

G32748 (e-PCR)
- UniSTS:117329

G33009 (e-PCR)
- UniSTS:117586

RH102522 (e-PCR)
- UniSTS:96856

RH120340 (e-PCR)
- UniSTS:132480

SNCA_s25 (e-PCR)
- UniSTS:513685

1332 (e-PCR)
- UniSTS:33225

A009Z12 (e-PCR)
- UniSTS:61918

SHGC-13157 (e-PCR)
- UniSTS:63982

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IPI Inferred from Physical Interaction more info	PubMed
enables alpha-tubulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables cuprous ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables cuprous ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
enables dynein complex binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables ferrous iron binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	EXP Inferred from Experiment more info	PubMed
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables phospholipase D inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables tau protein binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	TAS Traceable Author Statement more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in SNARE complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in adult locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in amyloid fibril formation	EXP Inferred from Experiment more info	PubMed
NOT involved_in calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to copper ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to epinephrine stimulus	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to oxidative stress	IC Inferred by Curator more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopamine biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in dopamine uptake involved in synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in localization	EXP Inferred from Experiment more info	PubMed
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	TAS Traceable Author Statement more info	PubMed
involved_in mitochondrial ATP synthesis coupled electron transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial membrane organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chaperone-mediated autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dopamine uptake involved in synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mitochondrial electron transport, NADH to ubiquinone	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of norepinephrine uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein kinase activity	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of serotonin uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of thrombin-activated receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in neutral lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SNARE complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization to cell periphery	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor recycling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in protein destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein tetramerization	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of acyl-CoA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopamine secretion	TAS Traceable Author Statement more info	PubMed
involved_in regulation of glutamate secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of locomotion	IEA Inferred from Electronic Annotation more info
involved_in regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in regulation of norepinephrine uptake	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of phospholipase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of reactive oxygen species biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in regulation of synaptic vesicle recycling	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to interleukin-1	IDA Inferred from Direct Assay more info	PubMed
involved_in response to iron(II) ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to magnesium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in supramolecular fiber organization	TAS Traceable Author Statement more info	PubMed
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle priming	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in inclusion body	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	TAS Traceable Author Statement more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with platelet alpha granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in supramolecular fiber	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-synuclein

Names: I+/--synuclein; non A-beta component of AD amyloid; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011851.1 RefSeqGene

Range

6136..119198

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000345.4 → NP_000336.1 alpha-synuclein isoform NACP140

See identical proteins and their annotated locations for NP_000336.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as NACP140) is the longest transcript and encodes the longer isoform (NACP140). Variants 1, 2, and 3 all encode the same isoform.

Source sequence(s)

AC097478, AI815523, BC108275

Consensus CDS

CCDS3634.1

UniProtKB/Swiss-Prot

A8K2A4, P37840, Q13701, Q4JHI3, Q6IAU6

UniProtKB/TrEMBL

A0A669KBH5

Related

ENSP00000378442.4, ENST00000394991.8

Conserved Domains (1) summary

pfam01387
Location:1 → 131

Synuclein
NM_001146054.2 → NP_001139526.1 alpha-synuclein isoform NACP140

See identical proteins and their annotated locations for NP_001139526.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (NACP140).

Source sequence(s)

AC093759, AC097478, BC013293

Consensus CDS

CCDS3634.1

UniProtKB/Swiss-Prot

A8K2A4, P37840, Q13701, Q4JHI3, Q6IAU6

UniProtKB/TrEMBL

A0A669KBH5

Related

ENSP00000378437.1, ENST00000394986.5

Conserved Domains (1) summary

pfam01387
Location:1 → 131

Synuclein
NM_001146055.2 → NP_001139527.1 alpha-synuclein isoform NACP140

See identical proteins and their annotated locations for NP_001139527.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (NACP140).

Source sequence(s)

AC093759, AC097478, DA391115

Consensus CDS

CCDS3634.1

UniProtKB/Swiss-Prot

A8K2A4, P37840, Q13701, Q4JHI3, Q6IAU6

UniProtKB/TrEMBL

A0A669KBH5

Related

ENSP00000338345.3, ENST00000336904.7

Conserved Domains (1) summary

pfam01387
Location:1 → 131

Synuclein
NM_001375285.1 → NP_001362214.1 alpha-synuclein isoform NACP140

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variants 1-3 and 6-8, encodes isoform NACP140.

Source sequence(s)

AC093759, AC097478

Consensus CDS

CCDS3634.1

UniProtKB/Swiss-Prot

A8K2A4, P37840, Q13701, Q4JHI3, Q6IAU6

UniProtKB/TrEMBL

A0A669KBH5

Conserved Domains (1) summary

pfam01387
Location:1 → 131

Synuclein
NM_001375286.1 → NP_001362215.1 alpha-synuclein isoform NACP140

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variants 1-3, 5, 7, and 8, encodes isoform NACP140.

Source sequence(s)

AC093759, AC097478

Consensus CDS

CCDS3634.1

UniProtKB/Swiss-Prot

A8K2A4, P37840, Q13701, Q4JHI3, Q6IAU6

UniProtKB/TrEMBL

A0A669KBH5

Related

ENSP00000422238.1, ENST00000506244.5

Conserved Domains (1) summary

pfam01387
Location:1 → 131

Synuclein
NM_001375287.1 → NP_001362216.1 alpha-synuclein isoform NACP140

Status: REVIEWED

Description

Transcript Variant: This variant (7), as well as variants 1-3, 5, 6, and 8, encodes isoform NACP140.

Source sequence(s)

AC093759, AC097478

Consensus CDS

CCDS3634.1

UniProtKB/Swiss-Prot

A8K2A4, P37840, Q13701, Q4JHI3, Q6IAU6

UniProtKB/TrEMBL

A0A669KBH5

Related

ENSP00000500990.1, ENST00000673718.1

Conserved Domains (1) summary

pfam01387
Location:1 → 131

Synuclein
NM_001375288.1 → NP_001362217.1 alpha-synuclein isoform NACP140

Status: REVIEWED

Description

Transcript Variant: This variant (8), as well as variants 1-3 and 5-7, encodes isoform NACP140.

Source sequence(s)

AC093759, AC097478

Consensus CDS

CCDS3634.1

UniProtKB/Swiss-Prot

A8K2A4, P37840, Q13701, Q4JHI3, Q6IAU6

UniProtKB/TrEMBL

A0A669KBH5

Related

ENSP00000426955.1, ENST00000508895.5

Conserved Domains (1) summary

pfam01387
Location:1 → 131

Synuclein
NM_001375290.1 → NP_001362219.1 alpha-synuclein isoform 3

Status: REVIEWED

Source sequence(s)

AC097478

Related

ENST00000673766.1

Conserved Domains (1) summary

pfam01387
Location:54 → 83

Synuclein
NM_007308.3 → NP_009292.1 alpha-synuclein isoform NACP112

See identical proteins and their annotated locations for NP_009292.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as NACP112) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (NACP112) has the same N- and C-termini but is shorter compared to isoform NACP140.

Source sequence(s)

AC093759, AC097478, D31839

Consensus CDS

CCDS43252.1

UniProtKB/TrEMBL

H6UYS5, Q4W5L2

Related

ENSP00000396241.2, ENST00000420646.6

Conserved Domains (1) summary

pfam01387
Location:1 → 112

Synuclein

RNA

NR_164674.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC093759, AC097478
NR_164675.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC093759, AC097478
NR_164676.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC093759, AC097478