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    Atad5 ATPase family, AAA domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 237877, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Atad5provided by MGI
    Official Full Name
    ATPase family, AAA domain containing 5provided by MGI
    Primary source
    MGI:MGI:2442925
    See related
    Ensembl:ENSMUSG00000017550 AllianceGenome:MGI:2442925
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm17; FRAG1; C130052G03Rik
    Summary
    Predicted to enable DNA binding activity and DNA clamp unloader activity. Involved in cell population proliferation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and nuclear DNA replication. Acts upstream of or within several processes, including intracellular signal transduction; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of B cell activation. Located in nucleus. Is expressed in liver; metanephros; midbrain ventricular layer; renal cortex; and telencephalon ventricular layer. Orthologous to human ATAD5 (ATPase family AAA domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14 (RPKM 5.8), CNS E11.5 (RPKM 5.5) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 47.48 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79980205..80026623)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80089379..80135797)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SUZ12 polycomb repressive complex 2 subunit Neighboring gene STARR-positive B cell enhancer ABC_E9368 Neighboring gene cytokine receptor-like factor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:79881110-79881263 Neighboring gene STARR-seq mESC enhancer starr_30136 Neighboring gene STARR-seq mESC enhancer starr_30137 Neighboring gene STARR-seq mESC enhancer starr_30138 Neighboring gene transcription elongation factor, mitochondrial Neighboring gene ArfGAP with dual PH domains 2, opposite strand Neighboring gene ArfGAP with dual PH domains 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Elg1, a central player in genome stability. Gazy I, et al. Mutat Res Rev Mutat Res, 2015 Jan-Mar. PMID 25795125
    2. ATAD5 deficiency decreases B cell division and Igh recombination. Zanotti KJ, et al. J Immunol, 2015 Jan 1. PMID 25404367, Free PMC Article
    3. Predisposition to cancer caused by genetic and functional defects of mammalian Atad5. Bell DW, et al. PLoS Genet, 2011 Aug. PMID 21901109, Free PMC Article
    4. Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Ishii H, et al. Proc Natl Acad Sci U S A, 2005 Jul 5. PMID 15983387, Free PMC Article
    5. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ12735

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA clamp unloader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA clamp unloader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of isotype switching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of nucleic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle G2/M phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitotic cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Elg1 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATPase family AAA domain-containing protein 5
    Names
    chromosome fragility associated gene 1
    chromosome fragility-associated gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029856.2 → NP_001025027.1  ATPase family AAA domain-containing protein 5

      See identical proteins and their annotated locations for NP_001025027.1

      Status: VALIDATED

      Source sequence(s)
      AL591113, AL663057, AL672178
      Consensus CDS
      CCDS25127.1
      UniProtKB/Swiss-Prot
      Q3TMG5, Q3UW85, Q3V306, Q3V3T9, Q4QY64, Q5SSK4, Q8BUH4, Q8CGG7
      UniProtKB/TrEMBL
      B2RUJ4
      Related
      ENSMUSP00000017694.6, ENSMUST00000017694.7
      Conserved Domains (1) summary
      cl21455
      Location:1115 → 1160
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      79980205..80026623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533234.4 → XP_006533297.1  ATPase family AAA domain-containing protein 5 isoform X3

      Conserved Domains (1) summary
      PRK04195
      Location:1036 → 1154
      PRK04195; replication factor C large subunit; Provisional

    2. XM_006533233.3 → XP_006533296.1  ATPase family AAA domain-containing protein 5 isoform X2

      Conserved Domains (1) summary
      PRK04195
      Location:1036 → 1154
      PRK04195; replication factor C large subunit; Provisional

    3. XM_006533232.4 → XP_006533295.1  ATPase family AAA domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      B2RUJ4, Z4YKQ9
      Related
      ENSMUSP00000103874.2, ENSMUST00000108239.7
      Conserved Domains (1) summary
      PRK04195
      Location:1036 → 1151
      PRK04195; replication factor C large subunit; Provisional

    4. XM_011248989.4 → XP_011247291.1  ATPase family AAA domain-containing protein 5 isoform X4

      Conserved Domains (1) summary
      PRK04195
      Location:398 → 516
      PRK04195; replication factor C large subunit; Provisional

    5. XM_017314529.2 → XP_017170018.1  ATPase family AAA domain-containing protein 5 isoform X5

      Related
      ENSMUST00000151815.8
      Conserved Domains (1) summary
      PRK04195
      Location:177 → 295
      PRK04195; replication factor C large subunit; Provisional

    RNA

    1. XR_004936950.1 RNA Sequence

    2. XR_001780002.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QY64.1 GenPept UniProtKB/Swiss-Prot:Q4QY64

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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