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    Sfrp4 secreted frizzled-related protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89803, updated on 18-Apr-2019

    Summary

    Official Symbol
    Sfrp4provided by RGD
    Official Full Name
    secreted frizzled-related protein 4provided by RGD
    Primary source
    RGD:621075
    See related
    Ensembl:ENSRNOG00000054957
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Wnt binding protein involved in modulation of Wnt signaling [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Uterus (RPKM 198.2), Muscle (RPKM 100.3) and 4 other tissues See more
    Orthologs

    Genomic context

    See Sfrp4 in Genome Data Viewer
    Location:
    17q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (47383983..47394065, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (56095166..56105248)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene probable G-protein coupled receptor 141-like Neighboring gene uncharacterized LOC102546469 Neighboring gene NME/NM23 family member 8 Neighboring gene ependymin related 1 Neighboring gene hypothetical LOC100361770

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Wnt-protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    bone morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    bone morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    decidualization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mammary gland involution IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of non-canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of non-canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of sodium-dependent phosphate transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of sodium-dependent phosphate transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphate ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of epidermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epidermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of keratinocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of keratinocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    secreted frizzled-related protein 4
    Names
    DDC-4 protein
    FRP
    frizzled related protein
    sFRP-4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053544.1NP_445996.1  secreted frizzled-related protein 4 precursor

      See identical proteins and their annotated locations for NP_445996.1

      Status: PROVISIONAL

      Source sequence(s)
      AF012891
      UniProtKB/Swiss-Prot
      Q9JLS4
      Related
      ENSRNOP00000075046.1, ENSRNOT00000079368.1
      Conserved Domains (2) summary
      cl02447
      Location:20146
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
      cl02512
      Location:188296
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      47383983..47394065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      51198532..51208589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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