Olig2 oligodendrocyte transcription factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Olig2provided by MGI
Official Full Name: oligodendrocyte transcription factor 2provided by MGI
Primary source: MGI:MGI:1355331
See related: Ensembl:ENSMUSG00000039830 AllianceGenome:MGI:1355331
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RK17; Olg-2; Bhlhb1; Oligo2; bHLHe19
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding activity; and identical protein binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; epidermis; future brain; genitourinary system; and retina. Orthologous to human OLIG2 (oligodendrocyte transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 9.5), cortex adult (RPKM 8.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 52.6 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (91016745..91025567)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (91225550..91228677)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

bHLH transcription factors Hes1, Ascl1 and Oligo2 exhibit different expression patterns in the process of physiological electric fields-induced neuronal differentiation.
Title: bHLH transcription factors Hes1, Ascl1 and Oligo2 exhibit different expression patterns in the process of physiological electric fields-induced neuronal differentiation.
OLIG2 is an in vivo bookmarking transcription factor in the developing neural tube in mouse.
Title: OLIG2 is an in vivo bookmarking transcription factor in the developing neural tube in mouse.
Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss-Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities.
Title: Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss-Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities.
Disruption of the anterior commissure in Olig2 deficient mice.
Title: Disruption of the anterior commissure in Olig2 deficient mice.
Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination.
Title: Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination.
OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma.
Title: OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma.
The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents.
Title: The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents.
Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice.
Title: Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice.
Effects of taxol on neuronal differentiation of postnatal neural stem cells cultured from mouse subventricular zone.
Title: Effects of taxol on neuronal differentiation of postnatal neural stem cells cultured from mouse subventricular zone.
Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2.
Title: Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2.

Submit: New GeneRIF Correction See all GeneRIFs (79)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

REN83531 (e-PCR)
- UniSTS:408329

REN83532 (e-PCR)
- UniSTS:408330

Olig2 (e-PCR), detects polymorphism
- UniSTS:259114

Olig2 (e-PCR), detects polymorphism
- UniSTS:259641

Olig2 (e-PCR), detects polymorphism
- UniSTS:545974

AI604895 (e-PCR)
- UniSTS:186081

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables HMG box domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nervous system development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte cell fate specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of oligodendrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spinal cord oligodendrocyte cell fate specification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within thalamus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: oligodendrocyte transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016967.2 → NP_058663.2 oligodendrocyte transcription factor 2

See identical proteins and their annotated locations for NP_058663.2

Status: VALIDATED

Source sequence(s)

BC051967

Consensus CDS

CCDS28323.1

UniProtKB/Swiss-Prot

Q9EQW6, Q9JKN4

UniProtKB/TrEMBL

Q542S0

Related

ENSMUSP00000036797.9, ENSMUST00000035608.10

Conserved Domains (1) summary

cd18940
Location:95 → 179

bHLH_TS_OLIG2; basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 2 (Oligo2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

91016745..91025567

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160000.1 → XP_036015893.1 oligodendrocyte transcription factor 2 isoform X1

UniProtKB/Swiss-Prot

Q9EQW6, Q9JKN4

UniProtKB/TrEMBL

Q542S0

Conserved Domains (1) summary

cd18940
Location:95 → 179

bHLH_TS_OLIG2; basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 2 (Oligo2) and similar proteins