Itga7 integrin alpha 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itga7provided by MGI
Official Full Name: integrin alpha 7provided by MGI
Primary source: MGI:MGI:102700
See related: Ensembl:ENSMUSG00000025348 AllianceGenome:MGI:102700
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: [a]7; alpha7
Summary: This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded transmembrane protein is the alpha subunit that forms a noncovalent heterodimer with the beta subunit to form the functional integrin receptor that binds to laminin. Mice lacking the encoded protein exhibit symptoms of progressive muscular dystrophy, impaired axonal regeneration and cerebral vascular defects. [provided by RefSeq, Aug 2016]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 28.3), heart adult (RPKM 26.2) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.2 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128769633..128794155)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128933421..128958286)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of alpha7 versus alpha3beta4 nicotinic receptor subtypes in mouse hippocampal neurons.
Title: Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of α7 versus α3β4 nicotinic receptor subtypes in mouse hippocampal neurons.
Integrin alpha7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice.
Title: Integrin α7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice.
Association between Decreased ITGA7 Levels and Increased Muscle alpha-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease.
Title: Association between Decreased ITGA7 Levels and Increased Muscle α-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease.
ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption.
Title: ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption.
Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7).
Title: Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7).
miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice.
Title: miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice.
Ptrh2 levels were up-regulated in dystrophin deficient mdx muscle, which correlates with the elevated levels of the a7b1 integrin observed in mdx muscle and Duchenne muscular dystrophy patients. Similar to the a7 integrin, Ptrh2 expression was decreased in laminin-a2 null gastrocnemius muscle
Title: PTRH2 gene mutation causes progressive congenital skeletal muscle pathology.
Deletion of integrin alpha7 subunit does not aggravate the phenotype of laminin alpha2 chain-deficient mice. laminin-211 and integrin alpha7beta1 have intersecting roles in skeletal muscle.
Title: Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.
Sarcospan-mediated amelioration of muscular dystrophy in mouse model is dependent on the presence of both utrophin and alpha7beta1 integrin.
Title: Sarcospan integration into laminin-binding adhesion complexes that ameliorate muscular dystrophy requires utrophin and α7 integrin.
loss of alpha7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice
Title: Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itga7 (e-PCR), detects polymorphism
- UniSTS:143623

Itga7 (e-PCR), detects polymorphism
- UniSTS:143624

AI266817 (e-PCR)
- UniSTS:160041

Itga7 (e-PCR), detects polymorphism
- UniSTS:256617

L23423 (e-PCR)
- UniSTS:124879

D10Mit269 (e-PCR), detects polymorphism
- UniSTS:126173

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
contributes_to laminin binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to laminin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell shape	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin alpha7-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha7-beta1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in muscle tendon junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: integrin alpha-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001330160.2 → NP_001317089.1 integrin alpha-7 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC122380

Consensus CDS

CCDS88118.1

UniProtKB/Swiss-Prot

O88731, O88732, P70350, Q61737, Q61738, Q61741

UniProtKB/TrEMBL

Q3TZS3

Related

ENSMUSP00000151960.2, ENSMUST00000218290.2

Conserved Domains (2) summary

smart00191
Location:381 → 433

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:475 → 965

Integrin_alpha2; Integrin alpha
NM_001406285.1 → NP_001393214.1 integrin alpha-7 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC122380
NM_001406286.1 → NP_001393215.1 integrin alpha-7 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC122380
NM_001406287.1 → NP_001393216.1 integrin alpha-7 isoform 5

Status: VALIDATED

Source sequence(s)

AC122380
NM_008398.3 → NP_032424.2 integrin alpha-7 isoform 1 precursor

See identical proteins and their annotated locations for NP_032424.2

Status: VALIDATED

Source sequence(s)

AC122380

Consensus CDS

CCDS24300.1

UniProtKB/Swiss-Prot

O88731, O88732, P70350, Q61737, Q61738, Q61741

UniProtKB/TrEMBL

G3X9Q1

Related

ENSMUSP00000096712.3, ENSMUST00000099112.4

Conserved Domains (2) summary

smart00191
Location:377 → 429

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:471 → 961

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

128769633..128794155

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244914.2 → XP_030100774.1 integrin alpha-7 isoform X4

Conserved Domains (2) summary

smart00191
Location:214 → 266

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:308 → 798

Integrin_alpha2; Integrin alpha
XM_006513270.4 → XP_006513333.1 integrin alpha-7 isoform X5

Conserved Domains (2) summary

smart00191
Location:213 → 265

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:307 → 797

Integrin_alpha2; Integrin alpha
XM_036155649.1 → XP_036011542.1 integrin alpha-7 isoform X6

Conserved Domains (2) summary

smart00191
Location:209 → 261

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:303 → 793

Integrin_alpha2; Integrin alpha
XM_030244916.2 → XP_030100776.1 integrin alpha-7 isoform X8

UniProtKB/Swiss-Prot

O88731, O88732, P70350, Q61737, Q61738, Q61741

Conserved Domains (2) summary

smart00191
Location:377 → 429

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:471 → 961

Integrin_alpha2; Integrin alpha
XM_030244915.2 → XP_030100775.1 integrin alpha-7 isoform X7

UniProtKB/Swiss-Prot

O88731, O88732, P70350, Q61737, Q61738, Q61741

UniProtKB/TrEMBL

A0A8V5L190

Related

ENSMUSP00000159495.1, ENSMUST00000240553.1

Conserved Domains (2) summary

smart00191
Location:421 → 473

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:515 → 1005

Integrin_alpha2; Integrin alpha
XM_017313813.3 → XP_017169302.1 integrin alpha-7 isoform X1

UniProtKB/Swiss-Prot

O88731, O88732, P70350, Q61737, Q61738, Q61741

Conserved Domains (2) summary

smart00191
Location:381 → 433

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:475 → 965

Integrin_alpha2; Integrin alpha
XM_006513269.5 → XP_006513332.1 integrin alpha-7 isoform X2

UniProtKB/Swiss-Prot

O88731, O88732, P70350, Q61737, Q61738, Q61741

Conserved Domains (2) summary

smart00191
Location:317 → 369

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:411 → 901

Integrin_alpha2; Integrin alpha
XM_030244913.2 → XP_030100773.1 integrin alpha-7 isoform X3

UniProtKB/Swiss-Prot

O88731, O88732, P70350, Q61737, Q61738, Q61741

Conserved Domains (2) summary

smart00191
Location:313 → 365

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:407 → 897

Integrin_alpha2; Integrin alpha