Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3caprovided by MGI
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaprovided by MGI
Primary source: MGI:MGI:1206581
See related: Ensembl:ENSMUSG00000027665 AllianceGenome:MGI:1206581
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p110; caPI3K; p110alpha; 6330412C24Rik
Summary: Enables 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding activity; and protein kinase activator activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of peptidyl-serine phosphorylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including energy homeostasis; negative regulation of apoptotic process; and protein kinase B signaling. Located in intercalated disc and lamellipodium. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including early embryo; eye; and nervous system. Used to study CLOVES syndrome and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 6.2), cerebellum adult (RPKM 5.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 15.7 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (32451203..32520256)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (32397065..32466112)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Generating a Murine PTEN Null Cell Line to Discover the Key Role of p110beta-PAK1 in Castration-Resistant Prostate Cancer Invasion.
Title: Generating a Murine PTEN Null Cell Line to Discover the Key Role of p110β-PAK1 in Castration-Resistant Prostate Cancer Invasion.
Urothelium-Specific Expression of Mutationally Activated Pik3ca Initiates Early Lesions of Noninvasive Bladder Cancer.
Title: Urothelium-Specific Expression of Mutationally Activated Pik3ca Initiates Early Lesions of Noninvasive Bladder Cancer.
Respective roles of Pik3ca mutations and cyproterone acetate impregnation in mouse meningioma tumorigenesis.
Title: Respective roles of Pik3ca mutations and cyproterone acetate impregnation in mouse meningioma tumorigenesis.
JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.
Title: JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.
Endothelial hyperactivation of mutant MAP3K3 induces cerebral cavernous malformation enhanced by PIK3CA GOF mutation.
Title: Endothelial hyperactivation of mutant MAP3K3 induces cerebral cavernous malformation enhanced by PIK3CA GOF mutation.
Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway.
Title: Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway.
PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption.
Title: PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption.
Double Deletion of PI3K and PTEN Modifies Lens Postnatal Growth and Homeostasis.
Title: Double Deletion of PI3K and PTEN Modifies Lens Postnatal Growth and Homeostasis.
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment.
Title: PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment.
RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.
Title: RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.

Submit: New GeneRIF Correction See all GeneRIFs (204)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (18) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126565 (e-PCR)
- UniSTS:209691

Pik3ca (e-PCR), detects polymorphism
- UniSTS:144180

UniSTS:257081 (e-PCR)
- UniSTS:257081

Pik3ca (e-PCR), detects polymorphism
- UniSTS:257081

UniSTS:257082 (e-PCR)
- UniSTS:257082

Pik3ca (e-PCR), detects polymorphism
- UniSTS:257082

UniSTS:257083 (e-PCR)
- UniSTS:257083

Pik3ca (e-PCR), detects polymorphism
- UniSTS:257083

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS Traceable Author Statement more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor substrate binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within TORC2 signaling	ISO Inferred from Sequence Orthology more info	PubMed
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_negative_effect autosome genomic imprinting	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydrostatic pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of actin filament depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fibroblast apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in relaxation of cardiac muscle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to muscle stretch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of phosphatidylinositol 3-kinase complex	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class IA	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IA	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class IB	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Names: PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphoinositide-3-kinase catalytic alpha polypeptide; ptdIns-3-kinase subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA

NP_032865.2

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008839.3 → NP_032865.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

See identical proteins and their annotated locations for NP_032865.2

Status: VALIDATED

Source sequence(s)

AC110034, AC130281

Consensus CDS

CCDS38409.1

UniProtKB/Swiss-Prot

P42337, Q0VGQ5

Related

ENSMUSP00000103878.2, ENSMUST00000108243.8

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam00794
Location:173 → 292

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain