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    SOL2 Sol2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850437, updated on 27-Jan-2024

    Summary

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    Gene symbol
    SOL2
    Gene description
    Sol2p
    Primary source
    SGD:S000000718
    Locus tag
    YCR073W-A
    See related
    AllianceGenome:SGD:S000000718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YCRX13W
    Summary
    Predicted to enable 6-phosphogluconolactonase activity. Involved in tRNA export from nucleus. Located in cytosol. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (246963..247910)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Rsa4p Neighboring gene mitogen-activated protein kinase kinase kinase SSK22 Neighboring gene cystinosin-like protein ERS1 Neighboring gene Ego2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family. Shen WC, et al. Genetics, 1996 Jun. PMID 8725220, Free PMC Article
    2. Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism. Stanford DR, et al. Genetics, 2004 Sep. PMID 15454531, Free PMC Article
    3. The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast. Musso G, et al. Genome Res, 2008 Jul. PMID 18463300, Free PMC Article
    4. Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Pinsky BA, et al. Mol Cell Biol, 2006 Apr. PMID 16537909, Free PMC Article
    5. Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Mok J, et al. Sci Signal, 2010 Feb 16. PMID 20159853, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 6-phosphogluconolactonase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphogluconolactonase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sol2p
    NP_009999.2
    • Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      246963..247910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178815.1 → NP_009999.2  TPA: Sol2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009999.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR76, P37262
      UniProtKB/TrEMBL
      A0A6L0YPQ2, A6ZTP7, C7GUX3, G2WA83
      Conserved Domains (1) summary
      cd01400
      Location:87 → 292
      6PGL; 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37262.2

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