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    MKS1 Mks1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855648, updated on 7-Apr-2024

    Summary

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    Gene symbol
    MKS1
    Gene description
    Mks1p
    Primary source
    SGD:S000005020
    Locus tag
    YNL076W
    See related
    AllianceGenome:SGD:S000005020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LYS80
    Summary
    Involved in several processes, including mitochondria-nucleus signaling pathway; negative regulation of transcription by RNA polymerase II; and regulation of pseudohyphal growth. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (483556..485310)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Nis1p Neighboring gene Apj1p Neighboring gene snoRNA-binding rRNA-processing protein IMP4 Neighboring gene Mlf3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nitrogen source and the retrograde signalling pathway affect detection, not generation, of the [URE3] prion. Edskes HK, et al. Yeast, 2006 Aug. PMID 16921555
    2. Mutation affecting the specific regulatory control of lysine biosynthetic enzymes in Saccharomyces cerevisiae. Ramos F, et al. Mol Gen Genet, 1985. PMID 3929019
    3. Mitochondrial Retrograde Signaling Contributes to Metabolic Differentiation in Yeast Colonies. Plocek V, et al. Int J Mol Sci, 2021 May 25. PMID 34070491, Free PMC Article
    4. Interaction between Rtg2p and Mks1p in the regulation of the RTG pathway of Saccharomyces cerevisiae. Ferreira Júnior JR, et al. Gene, 2005 Jul 18. PMID 15967597
    5. Lys80p of Saccharomyces cerevisiae, previously proposed as a specific repressor of LYS genes, is a pleiotropic regulatory factor identical to Mks1p. Feller A, et al. Yeast, 1997 Nov. PMID 9392078

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that dynamic association between Mks1p and Rtg2p in high molecular weight complexes provides a means to regulate the RTG pathway.
      Title: Interaction between Rtg2p and Mks1p in the regulation of the RTG pathway of Saccharomyces cerevisiae.
    2. Tor signaling and Mks1p phosphorylation regulate expression of Rtg1.Rtg3p-dependent target genes
      Title: Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1.Rtg3p-dependent target genes.
    3. Mks1p is a central player of retrograde signaling (RS) and is acted upon by multiple regulators of the pathway.
      Title: A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondria-nucleus signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondria-nucleus signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nitrogen utilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mks1p
    NP_014323.1
    • Pleiotropic negative transcriptional regulator; involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      483556..485310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182914.1 → NP_014323.1  TPA: Mks1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014323.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1A3, P34072, Q02533
      UniProtKB/TrEMBL
      A0A8H4BY21, B3LNT5, C8ZGF4, N1NXZ2
      Conserved Domains (1) summary
      pfam08550
      Location:37 → 64
      DUF1752; Fungal protein of unknown function (DUF1752)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34072.2

    Gene LinkOut

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