SMB1 mRNA splicing protein SMB1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SMB1
Gene description: mRNA splicing protein SMB1
Primary source: SGD:S000000831
Locus tag: YER029C
See related: AllianceGenome:SGD:S000000831
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of U2-type prespliceosome and spliceosomal snRNP complex. Human ortholog(s) of this gene implicated in cerebrocostomandibular syndrome and mixed connective tissue disease. Orthologous to several human genes including SNRPB (small nuclear ribonucleoprotein polypeptides B and B1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (212587..213177, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables snRNP binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
part_of U1 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U1 snRNP	IDA Inferred from Direct Assay more info	PubMed
part_of U2 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type prespliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type prespliceosome	IDA Inferred from Direct Assay more info	PubMed
part_of U4 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U4/U6 x U5 tri-snRNP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U4/U6 x U5 tri-snRNP complex	IDA Inferred from Direct Assay more info	PubMed
part_of U5 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U5 snRNP	IDA Inferred from Direct Assay more info	PubMed
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular organelle	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mRNA splicing protein SMB1

NP_010946.3

Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

212587..213177 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178920.3 → NP_010946.3 TPA: mRNA splicing protein SMB1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010946.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLS8, P40018

UniProtKB/TrEMBL

A0A6A5Q0I3, A6ZQX8, B3LS42, B5VHG4, C7GSH6, C8Z731, G2WCR2, N1P528

Conserved Domains (1) summary

cd01717
Location:8 → 98

Sm_B; Sm protein B

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
3JCM_O.1
3JCM_S.1
5GM6_k.1
5GMK_k.1
5GMK_s.1
5WSG_F.1
5WSG_k.1
5Y88_a.1
5Y88_h.1
5YLZ_a.1
5YLZ_h.1
5ZWM_P.1
5ZWM_a.1
5ZWM_h.1
5ZWN_a.1
5ZWO_P.1
5ZWO_a.1
5ZWO_h.1
6BK8_f.1
6BK8_k.1
6EXN_b.1
6EXN_k.1
6J6G_k.1
6J6G_s.1
6J6H_k.1
6J6H_s.1
6J6N_k.1
6J6N_s.1
6J6Q_k.1
6J6Q_s.1
6N7P_K.1
6N7R_K.1
6N7X_K.1
P40018.1