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    GTS1 Gts1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852694, updated on 13-Apr-2024

    Summary

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    Gene symbol
    GTS1
    Gene description
    Gts1p
    Primary source
    SGD:S000003149
    Locus tag
    YGL181W
    See related
    AllianceGenome:SGD:S000003149
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FHT1; LSR1
    Summary
    Enables DNA-binding transcription factor binding activity and GTPase activator activity. Involved in endocytosis; negative regulation of phosphatidylinositol biosynthetic process; and positive regulation of transcription by RNA polymerase II. Located in actin cortical patch and nucleus. Orthologous to human SMAP1 (small ArfGAP 1) and SMAP2 (small ArfGAP2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GTS1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (157906..159096)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene cystathionine beta-lyase STR3 Neighboring gene Mnd1p Neighboring gene serine/threonine protein kinase ATG1 Neighboring gene serine/threonine protein kinase TOS3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of Gts1p in regulation of energy-metabolism oscillation in continuous cultures of the yeast Saccharomyces cerevisiae. Xu Z, et al. Yeast, 2007 Mar. PMID 17351907
    2. Severe reduction of superoxide dismutase activity in the yeast Saccharomyces cerevisae with the deletion or overexpression of GTS1. Abudugupur A, et al. FEMS Microbiol Lett, 2003 Jun 6. PMID 12799013
    3. The Gts1 protein stabilizes the autonomous oscillator in yeast. Adams CA, et al. Yeast, 2003 Apr 30. PMID 12722180
    4. Regulation of the Gts1p level by the ubiquitination system to maintain metabolic oscillations in the continuous culture of yeast. Saito T, et al. J Biol Chem, 2002 Sep 13. PMID 12070147
    5. Analysis of the upstream regulatory region of the GTS1 gene required for its oscillatory expression. Tonozuka H, et al. J Biochem, 2001 Nov. PMID 11686920

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggested that Gts1p in the actin patch is involved in the fluid-phase endocytosis and membrane trafficking for vacuole formation and that the putative ARF-GAP domain in Gts1p plays an important role in these functions.
      Title: Localization of Gts1p in cortical actin patches of yeast and its possible role in endocytosis.
    2. Gts1p bound to the repressor Sfl1p, and their interaction at the transcriptional level was shown by reporter gene assays using the FLO1 promoter, suggesting that Gts1p induces the expression of FLO1 by inhibiting Sfl1p.
      Title: The mechanism by which overexpression of Gts1p induces flocculation in a FLO8-inactive strain of the yeast Saccharomyces cerevisiae.
    3. Gts1p plays a major role in the oscillatory expression of TPS1 and SUC2 in continuous cultures of Saccharomyces cerevisiae.
      Title: Gts1p stabilizes oscillations in energy metabolism by activating the transcription of TPS1 encoding trehalose-6-phosphate synthase 1 in the yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of phosphatidylinositol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gts1p
    NP_011334.1
    • Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      157906..159096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181046.1 → NP_011334.1  TPA: Gts1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011334.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTX2, P40956
      UniProtKB/TrEMBL
      A0A8H4FCS9, C8Z871, N1P4A8
      Conserved Domains (1) summary
      COG5347
      Location:8 → 310
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40956.2

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