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    PWP1 rRNA-processing protein PWP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850893, updated on 13-Apr-2024

    Summary

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    Gene symbol
    PWP1
    Gene description
    rRNA-processing protein PWP1
    Primary source
    SGD:S000004186
    Locus tag
    YLR196W
    See related
    AllianceGenome:SGD:S000004186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in rRNA processing. Located in cytoplasm and nucleolus. Orthologous to human PWP1 (PWP1 homolog, endonuclein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (543968..545698)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ncw2p Neighboring gene glycylpeptide N-tetradecanoyltransferase NMT1 Neighboring gene snoRNP complex protein NOP56 Neighboring gene Pba1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The WD40-repeat protein Pwp1p associates in vivo with 25S ribosomal chromatin in a histone H4 tail-dependent manner. Suka N, et al. Nucleic Acids Res, 2006. PMID 16855292, Free PMC Article
    2. The functional landscape of mouse gene expression. Zhang W, et al. J Biol, 2004. PMID 15588312, Free PMC Article
    3. Comparative analysis of the beta transducin family with identification of several new members including PWP1, a nonessential gene of Saccharomyces cerevisiae that is divergently transcribed from NMT1. Duronio RJ, et al. Proteins, 1992 May. PMID 1594577
    4. Cloning of a cDNA encoding a novel human nuclear phosphoprotein belonging to the WD-40 family. Honoré B, et al. Gene, 1994 Dec 30. PMID 7828893
    5. Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control. Meydan S, et al. Mol Cell, 2020 Aug 20. PMID 32615089, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Misfolded pre-rRNAs are stable in the absence of Nop12 but rapidly turned over when Pwp1 is not present.
      Title: Ribosome assembly factors Pwp1 and Nop12 are important for folding of 5.8S rRNA during ribosome biogenesis in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rRNA-processing protein PWP1
    NP_013297.1
    • Protein with WD-40 repeats involved in rRNA processing; associates with rDNA chromatin in H4-tail-dependent manner; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      543968..545698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182083.1 → NP_013297.1  TPA: rRNA-processing protein PWP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013297.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYJ9, P21304
      UniProtKB/TrEMBL
      A0A8H4BX69, A7A186, B3RH87, C7GIS8, N1NZT2
      Conserved Domains (2) summary
      COG2319
      Location:280 → 554
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:289 → 327
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21304.1

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