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    Crabp1 cellular retinoic acid binding protein I [ Mus musculus (house mouse) ]

    Gene ID: 12903, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Crabp1provided by MGI
    Official Full Name
    cellular retinoic acid binding protein Iprovided by MGI
    Primary source
    MGI:MGI:88490
    See related
    Ensembl:ENSMUSG00000032291 AllianceGenome:MGI:88490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rbp-5; CrabpI; CRABP-I; Crabp-1
    Summary
    Predicted to enable fatty acid binding activity and retinoic acid binding activity. Predicted to be involved in fatty acid transport. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human CRABP1 (cellular retinoic acid binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 232.5), limb E14.5 (RPKM 196.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A5.3; 9 29.76 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54672032..54680394)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54764748..54773110)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member A4 Neighboring gene microRNA 5710 Neighboring gene STARR-positive B cell enhancer ABC_E3830 Neighboring gene SKI8 subunit of superkiller complex Neighboring gene STARR-seq mESC enhancer starr_24173 Neighboring gene STARR-seq mESC enhancer starr_24174 Neighboring gene RAB7, member RAS oncogene family, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_24177 Neighboring gene STARR-seq mESC enhancer starr_24179 Neighboring gene STARR-positive B cell enhancer ABC_E2292 Neighboring gene iron responsive element binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration. Nhieu J, et al. Int J Mol Sci, 2023 Mar 4. PMID 36902410, Free PMC Article
    2. Modulation of adipose inflammation by cellular retinoic acid-binding protein 1. Wei CW, et al. Int J Obes (Lond), 2022 Oct. PMID 35794192, Free PMC Article
    3. Crabp1 Modulates HPA Axis Homeostasis and Anxiety-like Behaviors by Altering FKBP5 Expression. Lin YL, et al. Int J Mol Sci, 2021 Nov 12. PMID 34830120, Free PMC Article
    4. A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1. Park SW, et al. Sci Rep, 2019 Jul 29. PMID 31358819, Free PMC Article
    5. Cellular retinoic acid binding protein 1 protects mice from high-fat diet-induced obesity by decreasing adipocyte hypertrophy. Lin YW, et al. Int J Obes (Lond), 2020 Feb. PMID 31164723, Free PMC Article

    See all (248) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration.
      Title: Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration.
    2. Modulation of adipose inflammation by cellular retinoic acid-binding protein 1.
      Title: Modulation of adipose inflammation by cellular retinoic acid-binding protein 1.
    3. Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation.
      Title: Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation.
    4. Crabp1 Modulates HPA Axis Homeostasis and Anxiety-like Behaviors by Altering FKBP5 Expression.
      Title: Crabp1 Modulates HPA Axis Homeostasis and Anxiety-like Behaviors by Altering FKBP5 Expression.
    5. Sonic Hedgehog-Gli1 Signaling and Cellular Retinoic Acid Binding Protein 1 Gene Regulation in Motor Neuron Differentiation and Diseases.
      Title: Sonic Hedgehog-Gli1 Signaling and Cellular Retinoic Acid Binding Protein 1 Gene Regulation in Motor Neuron Differentiation and Diseases.
    6. Cellular retinoic acid binding protein 1 protects mice from high-fat diet-induced obesity by decreasing adipocyte hypertrophy.
      Title: Cellular retinoic acid binding protein 1 protects mice from high-fat diet-induced obesity by decreasing adipocyte hypertrophy.
    7. A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1.
      Title: A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1.
    8. These are supported by the fact that CRABP1 gene knockout (KO) mice exhibit multiple phenotypes including hippocampal NSC expansion and spontaneous cardiac hypertrophy. This indicates that more potential processes/signaling pathways involving atRA-CRABP1 may exist, which remain to be identified.
      Title: All-trans Retinoic Acid as a Versatile Cytosolic Signal Modulator Mediated by CRABP1.
    9. This is the first report of a physiological role of cellular retinoic acid binding protein I( CRABP)1 as an endogenous regulator of calcium-calmodulin protein kinase II, which protects the heart from isoproterenol-induced damage.
      Title: CRABP1 protects the heart from isoproterenol-induced acute and chronic remodeling.
    10. The physiological role of Crabp1 in modulating stem cell proliferation and hippocampus-dependent brain activities such as learning and memory.
      Title: Cellular Retinoic Acid-Binding Protein 1 Modulates Stem Cell Proliferation to Affect Learning and Memory in Male Mice.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinoid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables retinol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cellular retinoic acid-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284507.1 → NP_001271436.1  cellular retinoic acid-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001271436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC159892
      Conserved Domains (1) summary
      cl10502
      Location:2 → 99
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    2. NM_013496.3 → NP_038524.1  cellular retinoic acid-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_038524.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC159892, AK144397, CD742428
      Consensus CDS
      CCDS23195.1
      UniProtKB/Swiss-Prot
      P62965, Q3UN78
      Related
      ENSMUSP00000034830.9, ENSMUST00000034830.9
      Conserved Domains (1) summary
      cd19460
      Location:2 → 137
      CRABP1; cellular retinoic acid-binding protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      54672032..54680394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62965.2 GenPept UniProtKB/Swiss-Prot:P62965

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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