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    CkIIbeta Casein kinase II beta subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32132, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CkIIbetaprovided by FlyBase
    Official Full Name
    Casein kinase II beta subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000259
    Locus tag
    Dmel_CG15224
    See related
    AllianceGenome:FB:FBgn0000259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    And; betaCK2; Cask-II-b; CCK2; CG15224; CK II; CK-2; CK-II beta; Ck-IIbeta; CK-IIbeta; CK2; CK2-beta; ck2beta; Ck2beta; CK2beta; CkII; CKII; CKII beta; CkII-beta; CKII-beta1; CKIIb; Ckiibeta; CKIIbeta; CkIIbeta1; dCK2beta; dCKII; dCKII beta; Dm-CK2-beta; DmCK2beta; DmCkIIbeta; DmCKIIbeta; Dmel\CG15224; Ds cas kin; KC2B_DROME; mbu
    Summary
    Enables protein kinase regulator activity. Involved in several processes, including locomotor rhythm; mushroom body development; and oocyte dorsal/ventral axis specification. Located in cytosol and nucleus. Part of protein kinase CK2 complex. Is expressed in adult head. Orthologous to human CSNK2B (casein kinase 2 beta). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    10E3-10E3; 1-36 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11792533..11801587)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11686566..11695620)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene dusky Neighboring gene antisense RNA:CR44962 Neighboring gene karl Neighboring gene Heat shock protein 70 cognate 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of proteins that interact with Drosophila melanogaster protein kinase CK2. Trott RL, et al. Mol Cell Biochem, 2001 Nov. PMID 11827179
    2. Multiple, closely spaced alternative 5' exons in the DmCKIIbeta gene of Drosophila melanogaster. Bidwai AP, et al. Mol Cell Biol Res Commun, 2000 May. PMID 10964752
    3. An inhibitory effect of actin on casein kinase II activity in vitro. Karino A, et al. FEBS Lett, 1996 Dec 2. PMID 8977130
    4. Acquisition and amplification of a testis-expressed autosomal gene, SSL, by the Drosophila Y chromosome. Kalmykova AI, et al. Proc Natl Acad Sci U S A, 1997 Jun 10. PMID 9177211, Free PMC Article
    5. Modulation of the protein kinase CK2 activity by a synthetic peptide corresponding to the N-terminus of its beta regulatory subunit. Valero E, et al. Biochem Biophys Res Commun, 1997 Mar 6. PMID 9125126

    See all (171) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data (including data from studies using transgenic animals) suggest that catalytic activity of casein kinase 2 (CkIIa/CkIIb) is essential for oogenesis in this species; Jabba, a lipid droplet-associated protein and substrate for casein kinase 2, is essential in modulating ovarian lipid metabolism. (CkIIa = casein kinase II alpha subunit; CkIIb = casein kinase II beta subunit)
      Title: The protein kinase CK2 substrate Jabba modulates lipid metabolism during Drosophila oogenesis.
    2. Drosophila splicing factor P element Somatic Inhibitor (PSI) is phosphorylated at at least two different sites by at minimum two different kinases, casein kinase II (CK II) and tousled-like kinase (tlk).
      Title: The Drosophila splicing factor PSI is phosphorylated by casein kinase II and tousled-like kinase.
    3. Coexpressing CK2alpha and CK2beta increases Smo accumulation and induces ectopic Hh target gene expression.
      Title: Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus.
    4. This study implicates a role for DmCK2beta in cell proliferation or cell survival during brain development.
      Title: In vivo functional analysis of Drosophila protein kinase casein kinase 2 (CK2) beta-subunit.
    5. CK2(beta)tes encodes a testis-specific isoform of the regulatory subunit of casein kinase 2
      Title: CK2(beta)tes gene encodes a testis-specific isoform of the regulatory subunit of casein kinase 2 in Drosophila melanogaster.
    6. ZFP47 is a new physiological partner and substrate of CK2.
      Title: A gene located at 72A in Drosophila melanogaster encodes a novel zinc-finger protein that interacts with protein kinase CK2.
    7. Identification and characterization of proteins that interact with Drosophila melanogaster protein kinase CK2
      Title: Identification and characterization of proteins that interact with Drosophila melanogaster protein kinase CK2.
    8. The DmCK2beta transcription unit encodes for functionally non-redundant protein isoforms.
      Title: The Drosophila melanogaster DmCK2beta transcription unit encodes for functionally non-redundant protein isoforms.
    9. results reveal a potential mechanism for regulation of the dMi-2 enzyme and point toward CK2 phosphorylation as a common feature of CHD family ATPases
      Title: dMi-2 chromatin binding and remodeling activities are regulated by dCK2 phosphorylation.
    10. CK2beta is localized within clock neurons and the clock proteins Period (Per) and Timeless (Tim) accumulate to abnormally high levels in the Andante mutant, suggesting a function for CK2-dependent phosphorylation in the molecular oscillator
      Title: A role for CK2 in the Drosophila circadian oscillator.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eclosion rhythm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular mRNA localization involved in pattern specification process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte dorsal/ventral axis specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oocyte dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhythmic behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of protein kinase CK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase CK2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein kinase CK2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase II beta subunit
    Names
    CG15224-PB
    CG15224-PC
    CG15224-PD
    CG15224-PE
    CG15224-PF
    CG15224-PG
    CG15224-PH
    CG15224-PI
    CG15224-PJ
    CG15224-PK
    CK2 (beta subunit)
    CkIIbeta-PB
    CkIIbeta-PC
    CkIIbeta-PD
    CkIIbeta-PE
    CkIIbeta-PF
    CkIIbeta-PG
    CkIIbeta-PH
    CkIIbeta-PI
    CkIIbeta-PJ
    CkIIbeta-PK
    andante
    casein kinase 2
    casein kinase 2 regulatory subunit
    casein kinase II
    casein kinase II beta
    mushroom bodies undersized

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11792533..11801587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206692.3 → NP_996415.1  casein kinase II beta subunit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996415.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08182, Q76NS4, Q9VYU4
      UniProtKB/TrEMBL
      C9QPE1
      Conserved Domains (1) summary
      smart01085
      Location:8 → 191
      CK_II_beta; Casein kinase II regulatory subunit

    2. NM_080762.4 → NP_542940.1  casein kinase II beta subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_542940.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4C1, C9QPE1
      Related
      FBpp0073403
      Conserved Domains (1) summary
      smart01085
      Location:8 → 191
      CK_II_beta; Casein kinase II regulatory subunit

    3. NM_001258701.2 → NP_001245630.1  casein kinase II beta subunit, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245630.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPE1, M9NGA3
      Conserved Domains (1) summary
      smart01085
      Location:8 → 191
      CK_II_beta; Casein kinase II regulatory subunit

    4. NM_001258699.1 → NP_001245628.1  casein kinase II beta subunit, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245628.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4C1, C9QPE1
      Conserved Domains (1) summary
      smart01085
      Location:8 → 191
      CK_II_beta; Casein kinase II regulatory subunit

    5. NM_001258700.2 → NP_001245629.1  casein kinase II beta subunit, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245629.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPE1, M9NDU6
      Conserved Domains (1) summary
      smart01085
      Location:8 → 191
      CK_II_beta; Casein kinase II regulatory subunit

    6. NM_001272533.1 → NP_001259462.1  casein kinase II beta subunit, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259462.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPE1, M9PHA6
      Conserved Domains (1) summary
      smart01085
      Location:8 → 191
      CK_II_beta; Casein kinase II regulatory subunit

    7. NM_167304.3 → NP_727561.1  casein kinase II beta subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727561.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4C1, C9QPE1
      Related
      FBpp0073405
      Conserved Domains (1) summary
      smart01085
      Location:8 → 191
      CK_II_beta; Casein kinase II regulatory subunit

    8. NM_001014731.2 → NP_001014731.1  casein kinase II beta subunit, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014731.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4C1, C9QPE1
      Conserved Domains (1) summary
      smart01085
      Location:8 → 191
      CK_II_beta; Casein kinase II regulatory subunit

    9. NM_078576.5 → NP_511131.3  casein kinase II beta subunit, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511131.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4C1, C9QPE1
      Conserved Domains (1) summary
      smart01085
      Location:8 → 191
      CK_II_beta; Casein kinase II regulatory subunit

    10. NM_167305.3 → NP_727562.1  casein kinase II beta subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727562.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4C1, C9QPE1
      Related
      FBpp0073406
      Conserved Domains (1) summary
      smart01085
      Location:8 → 191
      CK_II_beta; Casein kinase II regulatory subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V4C1 A4V4C1
    M9NDU6 M9NDU6
    M9NGA3 M9NGA3
    M9PHA6 M9PHA6
    P08182.2 P08182
    Q9NGY7 Q9NGY7
    Q9NGY8 Q9NGY8
    Q9NGY9 Q9NGY9

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