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    ATP8A ATPase 8A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36488, updated on 27-Mar-2024

    Summary

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    Official Symbol
    ATP8Aprovided by FlyBase
    Official Full Name
    ATPase 8Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259221
    Locus tag
    Dmel_CG42321
    See related
    AllianceGenome:FB:FBgn0259221
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0153538.54; Atp8a; CG17034; CG30061; CG42321; DmCG42321; Dmel\CG42321
    Old locus tag
    Dmel_CG17034; Dmel_CG30061
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to be integral component of membrane. Predicted to be active in plasma membrane and trans-Golgi network. Is expressed in several structures, including dorsal sensory complex proper primordium; embryonic Malpighian tubule; embryonic hindgut; embryonic/larval nervous system; and extended germ band embryo. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome. Orthologous to several human genes including ATP8A2 (ATPase phospholipid transporting 8A2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    50A5-50A8; 2-68 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13414978..13439051, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9302483..9326556, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Baramicin A1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Isoleucine-AAT 1-3 Neighboring gene transfer RNA:Leucine-CAA 2-1 Neighboring gene transfer RNA:Isoleucine-AAT 1-4 Neighboring gene transfer RNA:Isoleucine-AAT 1-5 Neighboring gene transfer RNA:Isoleucine-AAT 1-6 Neighboring gene transfer RNA:Isoleucine-AAT 1-7 Neighboring gene transfer RNA:Leucine-CAA 1-1 Neighboring gene transfer RNA:Isoleucine-AAT 1-8 Neighboring gene uncharacterized protein Neighboring gene Ser8 Neighboring gene centrosomin Neighboring gene uncharacterized protein Neighboring gene Golgin 97

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylserine Externalization Results from and Causes Neurite Degeneration in Drosophila. Sapar ML, et al. Cell Rep, 2018 Aug 28. PMID 30157423, Free PMC Article
    2. Functions of phospholipid flippases. Tanaka K, et al. J Biochem, 2011 Feb. PMID 21134888
    3. Proper recruitment of gamma-tubulin and D-TACC/Msps to embryonic Drosophila centrosomes requires Centrosomin Motif 1. Zhang J, et al. Mol Biol Cell, 2007 Oct. PMID 17671162, Free PMC Article
    4. Phagocytosis and self-destruction break down dendrites of Drosophila sensory neurons at distinct steps of Wallerian degeneration. Ji H, et al. Proc Natl Acad Sci U S A, 2022 Jan 25. PMID 35058357, Free PMC Article
    5. Extreme deformability of insect cell membranes is governed by phospholipid scrambling. Shiomi A, et al. Cell Rep, 2021 Jun 8. PMID 34107250

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATPase 8A
    Names
    ATP8A-PE
    ATP8A-PG
    ATP8A-PH
    ATP8A-PI
    ATP8A-PJ
    ATP8A-PK
    ATP8A-PL
    ATP8A-PM
    ATP8A-PN
    ATP8A-PO
    ATP8A-PP
    ATP8A-PQ
    ATP8A-PR
    ATP8A-PS
    CG42321-PE
    CG42321-PG
    CG42321-PH
    CG42321-PI
    CG42321-PJ
    CG42321-PK
    CG42321-PL
    CG42321-PM
    CG42321-PN
    CG42321-PO
    CG42321-PP
    CG42321-PQ
    CG42321-PR
    CG42321-PS
    NP_001137649.1
    NP_001137650.1
    NP_001137651.1
    NP_001137652.1
    NP_001137653.1
    NP_001137654.1
    NP_001137655.1
    NP_001137656.1
    NP_001188919.1
    NP_001246290.1
    NP_610873.1
    NP_725290.2
    NP_725291.2
    NP_725292.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13414978..13439051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144182.3 → NP_001137654.1  ATPase 8A, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137654.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z766, Q8T0I4
      Conserved Domains (6) summary
      TIGR01652
      Location:55 → 1073
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:112 → 197
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:471 → 567
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:44 → 106
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:814 → 1066
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:768 → 827
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_137029.4 → NP_610873.1  ATPase 8A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z766, Q8T0I4
      Related
      FBpp0289032
      Conserved Domains (6) summary
      TIGR01652
      Location:55 → 1073
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:112 → 197
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:471 → 567
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:44 → 106
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:814 → 1066
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:768 → 827
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    3. NM_001144180.3 → NP_001137652.1  ATPase 8A, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZF7, D0Z766
      Conserved Domains (6) summary
      TIGR01652
      Location:55 → 1073
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:112 → 197
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:471 → 567
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:44 → 106
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:814 → 1066
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:768 → 827
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    4. NM_165984.4 → NP_725290.2  ATPase 8A, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725290.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9C8, D0Z766
      Conserved Domains (6) summary
      TIGR01652
      Location:55 → 1073
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:112 → 197
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:471 → 567
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:44 → 106
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:814 → 1066
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:768 → 827
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    5. NM_001144177.3 → NP_001137649.1  ATPase 8A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137649.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZF5, D0Z766
      Conserved Domains (6) summary
      TIGR01652
      Location:229 → 1247
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:286 → 371
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:645 → 741
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:218 → 280
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:988 → 1240
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:942 → 1001
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    6. NM_001144179.3 → NP_001137651.1  ATPase 8A, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137651.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZF8
      Conserved Domains (6) summary
      TIGR01652
      Location:229 → 1247
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:286 → 371
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:645 → 741
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:218 → 280
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:988 → 1240
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:942 → 1001
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    7. NM_170625.4 → NP_725292.2  ATPase 8A, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725292.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZF6, D0Z766
      Conserved Domains (6) summary
      TIGR01652
      Location:180 → 1198
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:237 → 322
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:596 → 692
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:169 → 231
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:939 → 1191
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:893 → 952
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    8. NM_001144183.3 → NP_001137655.1  ATPase 8A, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137655.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZF6, D0Z766
      Conserved Domains (6) summary
      TIGR01652
      Location:180 → 1198
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:237 → 322
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:596 → 692
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:169 → 231
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:939 → 1191
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:893 → 952
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    9. NM_170624.4 → NP_725291.2  ATPase 8A, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725291.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z766, Q0E990
      Conserved Domains (6) summary
      TIGR01652
      Location:180 → 1198
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:237 → 322
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:596 → 692
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:169 → 231
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:939 → 1191
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:893 → 952
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    10. NM_001259361.1 → NP_001246290.1  ATPase 8A, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246290.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7Y0, D0Z766
      Conserved Domains (6) summary
      TIGR01652
      Location:49 → 1067
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:106 → 191
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:465 → 561
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:38 → 100
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:808 → 1060
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:762 → 821
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    11. NM_001144181.3 → NP_001137653.1  ATPase 8A, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZF9, D0Z766
      Conserved Domains (6) summary
      TIGR01652
      Location:55 → 1073
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:112 → 197
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:471 → 567
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:44 → 106
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:814 → 1066
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:768 → 827
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    12. NM_001144184.3 → NP_001137656.1  ATPase 8A, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137656.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZG0, D0Z766
      Conserved Domains (6) summary
      TIGR01652
      Location:229 → 1247
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:286 → 371
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:645 → 741
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:218 → 280
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:988 → 1240
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:942 → 1001
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    13. NM_001144178.3 → NP_001137650.1  ATPase 8A, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137650.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z766, Q6AWM7
      Conserved Domains (6) summary
      TIGR01652
      Location:180 → 1198
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:237 → 322
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:596 → 692
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:169 → 231
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:939 → 1191
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:893 → 952
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    14. NM_001201990.1 → NP_001188919.1  ATPase 8A, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188919.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD16, D0Z766
      Conserved Domains (6) summary
      TIGR01652
      Location:46 → 1064
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:103 → 188
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:462 → 558
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:35 → 97
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:805 → 1057
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:759 → 818
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD16 A0A0B4JD16
    A0A0B4K7Y0 A0A0B4K7Y0
    A1Z9C8 A1Z9C8
    B7YZF5 B7YZF5
    B7YZF6 B7YZF6
    B7YZF7 B7YZF7
    B7YZF8 B7YZF8
    B7YZF9 B7YZF9
    B7YZG0 B7YZG0
    Q0E990 Q0E990
    Q6AWM7 Q6AWM7
    Q8T0I4 Q8T0I4

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