E(spl)mgamma-HLH Enhancer of split mgamma, helix-loop-helix [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: E(spl)mgamma-HLHprovided by FlyBase
Official Full Name: Enhancer of split mgamma, helix-loop-helixprovided by FlyBase
Primary source: FLYBASE:FBgn0002735
Locus tag: Dmel_CG8333
See related: AllianceGenome:FB:FBgn0002735
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-1.49; bHLHb34; CG8333; clone 1.49; Dm-mB; Dmel\CG8333; E(Spl) HLH-m gamma; E(spl) m gamma; E(spl) mg; E(spl) mgamma; E(spl)-mgamma; E(spl)gamma; E(spl)m-gamma; E(spl)mB; e(spl)mgamma; E(spl)mgamma; E(spl)Mgamma; EE(spl)mgamma-HLH; Enhancer of split mgamma; gamma; HLH-mgamma; HLHmB; HlHmg; HLHmgamma; HLHMgamma; mB; mg; mgamma; Mgamma
Summary: Enables DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including neuronal stem cell population maintenance; positive regulation of neuroblast proliferation; and wing disc dorsal/ventral pattern formation. Located in nucleus. Is expressed in several structures, including extended germ band embryo; germ layer; larval optic anlage; presumptive embryonic/larval central nervous system; and thoracic segment. Used to study central nervous system cancer. Orthologous to human HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See E(spl)mgamma-HLH in Genome Data Viewer

Location:: 96F9-96F9; 3-89 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25999851..26000761)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21825573..21826483)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that E(spl) proteins m7 and mgamma are potent inhibitors of neural fate, even in the presence of excess Sc activity and even when their DNA-binding basic domain has been inactivated
Title: Two modes of recruitment of E(spl) repressors onto target genes.
the Sc C-terminal domain is required for E(spl) recruitment in an enhancer context-dependent fashion, suggesting that in some enhancers alternative interaction surfaces can be used to recruit E(spl) proteins
Title: Role of the Sc C terminus in transcriptional activation and E(spl) repressor recruitment.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	IGI Inferred from Genetic Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: enhancer of split mgamma, helix-loop-helix

Names: CG8333-PA; E(spl) region transcript g; E(spl) region transcript mgamma; E(spl)mgamma-HLH-PA; enhancer of split; enhancer of split mgamma; enhancer of split region transcript HLHmB; mgamma; split locus enhancer protein mB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

25999851..26000761

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079780.3 → NP_524504.2 enhancer of split mgamma, helix-loop-helix [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524504.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q01070, Q01898, Q5S4K4

Related

FBpp0084329

Conserved Domains (2) summary

smart00511
Location:91 → 135

ORANGE; Orange domain

cd00083
Location:15 → 77

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...