ABP1 Abp1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: ABP1
Gene description: Abp1p
Primary source: SGD:S000000684
Locus tag: YCR088W
See related: AllianceGenome:SGD:S000000684
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables actin filament binding activity. Involved in actin cortical patch assembly; protein localization to actin cortical patch; and regulation of actin filament organization. Located in actin cortical patch. Orthologous to several human genes including DBNL (drebrin like). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

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A disordered encounter complex is central to the yeast Abp1p SH3 domain binding pathway.
Title: A disordered encounter complex is central to the yeast Abp1p SH3 domain binding pathway.
Data iindicate a role for Abp1 in protecting filament junctions from glia maturation factor (GMF)-induced debranching by competing with GMF for Arp2/3 complex binding.
Title: Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF.
Data imply that the AbpSH3 must bind extended target sites to function efficiently inside the cell.
Title: Structural, functional, and bioinformatic studies demonstrate the crucial role of an extended peptide binding site for the SH3 domain of yeast Abp1p.
These data provide the first evidence of biological relevance for any Abp1p SH3 domain-mediated interaction.
Title: The biologically relevant targets and binding affinity requirements for the function of the yeast actin-binding protein 1 Src-homology 3 domain vary with genetic context.
a structural and functional view of the Abp1-actin interaction and demonstration that Abp1 has distinct cellular roles as an adapter, linking different sets of ligands for each function
Title: Structural and functional dissection of the Abp1 ADFH actin-binding domain reveals versatile in vivo adapter functions.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cortical patch assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in barbed-end actin filament capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to actin cortical patch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
located_in actin cortical patch	IEA Inferred from Electronic Annotation more info
colocalizes_with actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IEA Inferred from Electronic Annotation more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in mating projection tip	HDA more info	PubMed
is_active_in site of polarized growth	IBA Inferred from Biological aspect of Ancestor more info

NP_010012.1

Actin-binding protein of the cortical actin cytoskeleton; important for activation of actin nucleation mediated by the Arp2/Arp3 complex; inhibits actin filament elongation at the barbed-end; phosphorylation within its proline-rich region, mediated by Cdc28p and Pho85p, protects Abp1p from PEST sequence-mediated proteolysis; mammalian homolog of HIP-55 (hematopoietic progenitor kinase 1 [HPK1]-interacting protein of 55 kDa)

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