rln3a relaxin 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rln3aprovided by ZNC
Official Full Name: relaxin 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050310-3
See related: Ensembl:ENSDARG00000070780 AllianceGenome:ZFIN:ZDB-GENE-050310-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rln3; RFLC2; rlx3a; rlx 3a
Summary: Predicted to enable G protein-coupled receptor binding activity. Predicted to be located in extracellular region. Is expressed in several structures, including female organism; gonad; intestine; male organism; and nervous system. Orthologous to human RLN3 (relaxin 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (19207243..19210442)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (19057503..19060702)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we report the expression pattern of the duplicated zebrafish rln3b gene and compare it to the previously analyszd spatial expression pattern of the rln3a gene
Title: Duplicated zebrafish relaxin-3 gene shows a different expression pattern from that of the co-orthologue gene.
Ovarian expression of relaxin-3a, d and f genes, and the relaxin-3 receptor gene Rxfp3, was studied in Danio rerio.
Title: Relaxin-3 and RXFP3 expression, and steroidogenic actions in the ovary of teleost fish.
pattern indicates both conserved and divergent expression features of the relaxin-3 gene among developing zebrafish
Title: Two neuron clusters in the stem of postembryonic zebrafish brain specifically express relaxin-3 gene: first evidence of nucleus incertus in fish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: relaxin-3a

Names: relaxin 3; relaxin family locus C type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037803.1 → NP_001032892.1 relaxin-3a precursor

See identical proteins and their annotated locations for NP_001032892.1

Status: PROVISIONAL

Source sequence(s)

AY834223

UniProtKB/TrEMBL

B1AAQ7, F6NV39, Q2VT45

Related

ENSDARP00000082236.4, ENSDART00000087803.5

Conserved Domains (1) summary

cd04365
Location:27 → 152

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...