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Tcf7l2 transcription factor 7 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 679869, updated on 11-Apr-2024

Summary

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Symbol: Tcf7l2provided by RGD
Full Name: transcription factor 7 like 2provided by RGD
Primary source: RGD:1583621
See related: Ensembl:ENSRNOG00000049232 AllianceGenome:RGD:1583621
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; armadillo repeat domain binding activity; and beta-catenin binding activity. Involved in negative regulation of apoptotic process and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of beta-catenin-TCF7L2 complex and protein-DNA complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 33.3), Kidney (RPKM 29.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Tcf7l2 in Genome Data Viewer

Location:: 1q55

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (264791335..264984225)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (254785956..254978967)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (276686911..276730517)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-212 Promotes Cardiomyocyte Hypertrophy through Regulating Transcription Factor 7 Like 2.
Title: miR-212 Promotes Cardiomyocyte Hypertrophy through Regulating Transcription Factor 7 Like 2.
The TCF7L2-dependent high-voltage activated calcium channel subunit alpha2delta-1 controls calcium signaling in rodent pancreatic beta-cells.
Title: The TCF7L2-dependent high-voltage activated calcium channel subunit α2δ-1 controls calcium signaling in rodent pancreatic beta-cells.
Findings reveal a crucial role for the diabetes-associated transcription factor TCF7L2 in regulating the function of nicotinic acetylcholine receptors in the habenula and in controlling nicotine intake.
Title: Habenular TCF7L2 links nicotine addiction to diabetes.
miR-182 exacerbated acute kidney injury by targeting and regulation of TCF7L2/Wnt/beta-catenin signaling.
Title: miR-182 enhances acute kidney injury by promoting apoptosis involving the targeting and regulation of TCF7L2/Wnt/β-catenins pathway.
Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-Tp53INP1-dependent pathway.
Title: Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.
It was shown that TCF7L2 is an important regulator of hepatic glucose production in vitro and binds directly to genes that are important in pathways of glucose metabolism in the liver.
Title: Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism.
TCF7L2 downregulation affects the normal growth of the beta-cells. TCF7L2 knockdown significantly alters the process of beta-cell regeneration in diabetic rats.
Title: Neonatal growth and regeneration of beta-cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats.
Inhibition of Wnt signaling by small interfering RNAs to beta-catenin or a dominant-negative TCF7L2 decreases both basal and exendin-4-induced beta cell proliferation
Title: Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation.
While TCF7L2 mRNA levels were increased in isolated islets from the diabetic rat, protein levels were decreased.
Title: Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.
TGF-beta signaling enhances TCF-4 and lymphoid enhancing factor-1 mRNA expression and increases TCF-4 transcriptional activity.
Title: Novel links among Wnt and TGF-beta signaling and Runx2.

Submit: New GeneRIF Correction

General gene information

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Markers

Tcf7l2 (e-PCR), detects polymorphism
- UniSTS:239190

RH138714 (e-PCR)
- UniSTS:220801

BF398115 (e-PCR)
- UniSTS:246684

D1Got256 (e-PCR)
- UniSTS:114344

BE106867 (e-PCR)
- UniSTS:246453

RH142640 (e-PCR)
- UniSTS:231887

AI502021 (e-PCR)
- UniSTS:261357

Tcf7l2 (e-PCR), detects polymorphism
- UniSTS:507888

BF396325 (e-PCR)
- UniSTS:245746

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic hindgut morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within face morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycogen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within insulin metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in maintenance of DNA repeat elements	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myoblast fate commitment	ISO Inferred from Sequence Orthology more info
involved_in myoblast fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type B pancreatic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of organ growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pituitary gland development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of hormone metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within secretory granule localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin-TCF7L2 complex	ISO Inferred from Sequence Orthology more info
part_of catenin-TCF7L2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin-TCF7L2 complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor 7-like 2

Names: transcription factor 7-like 2 (T-cell specific, HMG-box)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415805.2 → NP_001402734.1 transcription factor 7-like 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

264791335..264984225

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090214.2 → XP_038946142.1 transcription factor 7-like 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:406 → 473

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 307

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090218.2 → XP_038946146.1 transcription factor 7-like 2 isoform X4

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:401 → 468

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 307

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090216.2 → XP_038946144.1 transcription factor 7-like 2 isoform X3

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:402 → 469

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 307

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090221.2 → XP_038946149.1 transcription factor 7-like 2 isoform X6

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:397 → 464

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 307

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090215.2 → XP_038946143.1 transcription factor 7-like 2 isoform X2

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:405 → 472

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 306

CTNNB1_binding; N-terminal CTNNB1 binding
XM_063273365.1 → XP_063129435.1 transcription factor 7-like 2 isoform X5
XM_063273382.1 → XP_063129452.1 transcription factor 7-like 2 isoform X7
XM_039090232.2 → XP_038946160.1 transcription factor 7-like 2 isoform X10

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:358 → 425

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_063273464.1 → XP_063129534.1 transcription factor 7-like 2 isoform X33
XM_063273402.1 → XP_063129472.1 transcription factor 7-like 2 isoform X14
XM_039090268.2 → XP_038946196.1 transcription factor 7-like 2 isoform X13

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:358 → 425

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090377.2 → XP_038946305.1 transcription factor 7-like 2 isoform X38

UniProtKB/TrEMBL

A6JI05

Conserved Domains (2) summary

cd01388
Location:358 → 425

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090352.2 → XP_038946280.1 transcription factor 7-like 2 isoform X34

Conserved Domains (2) summary

cd01388
Location:353 → 420

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090276.2 → XP_038946204.1 transcription factor 7-like 2 isoform X16

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:353 → 420

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090271.2 → XP_038946199.1 transcription factor 7-like 2 isoform X15

UniProtKB/TrEMBL

A0A8I6A9A2, A0A8I6AGH1

Related

ENSRNOP00000092403.1
XM_039090379.2 → XP_038946307.1 transcription factor 7-like 2 isoform X39

UniProtKB/TrEMBL

A0A8I6A761, A6JI05

Related

ENSRNOP00000086842.1

Conserved Domains (2) summary

cd01388
Location:353 → 420

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090241.2 → XP_038946169.1 transcription factor 7-like 2 isoform X11

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:354 → 421

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090263.2 → XP_038946191.1 transcription factor 7-like 2 isoform X12

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:349 → 416

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090360.2 → XP_038946288.1 transcription factor 7-like 2 isoform X35

Conserved Domains (2) summary

cd01388
Location:349 → 416

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_063273415.1 → XP_063129485.1 transcription factor 7-like 2 isoform X18
XM_039090388.2 → XP_038946316.1 transcription factor 7-like 2 isoform X41

UniProtKB/TrEMBL

A6JI05

Conserved Domains (2) summary

cd01388
Location:349 → 416

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090226.2 → XP_038946154.1 transcription factor 7-like 2 isoform X8

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:382 → 449

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 283

CTNNB1_binding; N-terminal CTNNB1 binding
XM_063273389.1 → XP_063129459.1 transcription factor 7-like 2 isoform X9
XM_063273458.1 → XP_063129528.1 transcription factor 7-like 2 isoform X30
XM_039090344.2 → XP_038946272.1 transcription factor 7-like 2 isoform X32
XM_039090279.2 → XP_038946207.1 transcription factor 7-like 2 isoform X17

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:335 → 402

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090384.2 → XP_038946312.1 transcription factor 7-like 2 isoform X40

UniProtKB/TrEMBL

A6JI05

Conserved Domains (2) summary

cd01388
Location:335 → 402

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_063273435.1 → XP_063129505.1 transcription factor 7-like 2 isoform X23
XM_039090292.2 → XP_038946220.1 transcription factor 7-like 2 isoform X22

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:335 → 402

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090409.2 → XP_038946337.1 transcription factor 7-like 2 isoform X45

UniProtKB/TrEMBL

A6JI05

Conserved Domains (2) summary

cd01388
Location:335 → 402

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090283.2 → XP_038946211.1 transcription factor 7-like 2 isoform X20

UniProtKB/TrEMBL

A0A8I6A9A2, D3Z9D1

Related

ENSRNOP00000050120.5

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090393.2 → XP_038946321.1 transcription factor 7-like 2 isoform X42

UniProtKB/TrEMBL

A6JI05

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090300.2 → XP_038946228.1 transcription factor 7-like 2 isoform X25

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090297.2 → XP_038946225.1 transcription factor 7-like 2 isoform X24

UniProtKB/TrEMBL

A0A8I6A9A2, A0A8I6ARM6

Related

ENSRNOP00000095963.1

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090415.2 → XP_038946343.1 transcription factor 7-like 2 isoform X46

UniProtKB/TrEMBL

A6JI05

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_063273417.1 → XP_063129487.1 transcription factor 7-like 2 isoform X19
XM_039090286.2 → XP_038946214.1 transcription factor 7-like 2 isoform X21

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090397.2 → XP_038946325.1 transcription factor 7-like 2 isoform X43

UniProtKB/TrEMBL

A6JI05

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090305.2 → XP_038946233.1 transcription factor 7-like 2 isoform X26

UniProtKB/TrEMBL

A0A8I6A9A2

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090417.2 → XP_038946345.1 transcription factor 7-like 2 isoform X47

UniProtKB/TrEMBL

A6JI05

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090317.2 → XP_038946245.1 transcription factor 7-like 2 isoform X28

Conserved Domains (2) summary

cd01388
Location:406 → 473

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 307

CTNNB1_binding; N-terminal CTNNB1 binding
XM_063273456.1 → XP_063129526.1 transcription factor 7-like 2 isoform X29
XM_039090306.2 → XP_038946234.1 transcription factor 7-like 2 isoform X27

Conserved Domains (2) summary

cd01388
Location:406 → 473

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 307

CTNNB1_binding; N-terminal CTNNB1 binding
XM_063273461.1 → XP_063129531.1 transcription factor 7-like 2 isoform X31
XM_039090370.2 → XP_038946298.1 transcription factor 7-like 2 isoform X36

Conserved Domains (2) summary

cd01388
Location:335 → 402

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090375.2 → XP_038946303.1 transcription factor 7-like 2 isoform X37

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_039090403.2 → XP_038946331.1 transcription factor 7-like 2 isoform X44

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_063273448.1 → XP_063129518.1 transcription factor 7-like 2 isoform X27

RNA

XR_005492199.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001191052.2: Suppressed sequence

Description

NM_001191052.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.