Htr1a 5-hydroxytryptamine receptor 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Htr1aprovided by RGD
Official Full Name: 5-hydroxytryptamine receptor 1Aprovided by RGD
Primary source: RGD:2845
See related: Ensembl:ENSRNOG00000010254 AllianceGenome:RGD:2845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 5HT1A; RAT5HT1A
Summary: Enables several functions, including G protein-coupled serotonin receptor activity; G-protein alpha-subunit binding activity; and serotonin binding activity. Involved in several processes, including NMDA glutamate receptor clustering; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and regulation of secretion. Located in axon hillock. Is active in GABA-ergic synapse. Is integral component of presynaptic membrane. Used to study Parkinson's disease and panic disorder. Human ortholog(s) of this gene implicated in anxiety disorder; mental depression; and panic disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 2q13

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (38427169..38431733)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (36693462..36698026)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (36246628..36247896)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of 5-HT1A Receptors Normalizes the Overexpression of Presynaptic 5-HT1A Receptors and Alleviates Diabetic Neuropathic Pain.
Title: Activation of 5-HT1A Receptors Normalizes the Overexpression of Presynaptic 5-HT1A Receptors and Alleviates Diabetic Neuropathic Pain.
Chronic mild stress induces differential depression-like symptoms and c-Fos and 5HT1A protein levels in high-anxiety female Long Evans rats.
Title: Chronic mild stress induces differential depression-like symptoms and c-Fos and 5HT1A protein levels in high-anxiety female Long Evans rats.
Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo.
Title: Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo.
Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex.
Title: Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex.
A Comparative In Vitro Study of the Neuroprotective Effect Induced by Cannabidiol, Cannabigerol, and Their Respective Acid Forms: Relevance of the 5-HT1A Receptors.
Title: A Comparative In Vitro Study of the Neuroprotective Effect Induced by Cannabidiol, Cannabigerol, and Their Respective Acid Forms: Relevance of the 5-HT(1A) Receptors.
Role of 5-HT1A and 5-HT3 receptors in serotonergic activation of sensory neurons in relation to itch and pain behavior in the rat.
Title: Role of 5-HT1A and 5-HT3 receptors in serotonergic activation of sensory neurons in relation to itch and pain behavior in the rat.
5-HT1A receptor agonism in the basolateral amygdala increases mutual-reward choices in rats.
Title: 5-HT(1A) receptor agonism in the basolateral amygdala increases mutual-reward choices in rats.
Down-regulation of HTR1As modulates anterior cingulate cortex activation probably through activating ERK and Akt pathways, thus contributes to the formation of stress-induced visceral hyperalgesia.
Title: Down-regulation of HTR1A-modulated ACC activation contributes to stress-induced visceral hyperalgesia in rats.
miR-18a-5p may be a negative epigenetic regulator of 5-HT1AR.
Title: Resilient Phenotype in Chronic Mild Stress Paradigm Is Associated with Altered Expression Levels of miR-18a-5p and Serotonin 5-HT(1a) Receptor in Dorsal Part of the Hippocampus.
5-HT1A receptors in the retina were downregulated after intraocular pressure elevation. Activation of 5-HT1A receptors in retinas facilitated presynaptic GABA release functions by suppressing cAMP-PKA signaling and decreasing PKA phosphorylation, which could lead to the de-excitation of RGC circuits and suppress excitotoxic processes in glaucoma.
Title: Activation of 5-HT1A Receptors Promotes Retinal Ganglion Cell Function by Inhibiting the cAMP-PKA Pathway to Modulate Presynaptic GABA Release in Chronic Glaucoma.

Submit: New GeneRIF Correction See all GeneRIFs (152)

General gene information

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Markers

D2Rat114 (e-PCR)
- UniSTS:118655

D2Wox65 (e-PCR)
- UniSTS:518798

D2Mit31 (e-PCR), detects polymorphism
- UniSTS:240029

D2Wox63 (e-PCR)
- UniSTS:518871

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor-receptor interaction	ISO Inferred from Sequence Orthology more info
enables serotonin binding	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in NMDA glutamate receptor clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in behavioral fear response	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in exploration behavior	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gamma-aminobutyric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of serotonin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of serotonin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in serotonin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in serotonin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in serotonin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axon hillock	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynaptic membrane	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1A

Names: 5-HT-1A; 5-HT1A; 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; serotonin 1A receptor; serotonin 5-HT1A receptor; serotonin receptor 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.