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    ntr-1 G-protein coupled receptors family 1 profile domain-containing protein;Nematocin receptor 1 [ Caenorhabditis elegans ]

    Gene ID: 188227, updated on 11-Apr-2024

    Summary

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    Gene symbol
    ntr-1
    Gene description
    G-protein coupled receptors family 1 profile domain-containing protein;Nematocin receptor 1
    Primary source
    WormBase:WBGene00011582
    Locus tag
    CELE_T07D10.2
    See related
    AllianceGenome:WB:WBGene00011582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in intestine and neurons. Human ortholog(s) of this gene implicated in autism spectrum disorder; hypertension; mood disorder (multiple); nephrogenic diabetes insipidus; and nephrogenic syndrome of inappropriate antidiuresis. Orthologous to several human genes including AVPR1B (arginine vasopressin receptor 1B) and AVPR2 (arginine vasopressin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (12615921..12624241)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CX domain-containing protein Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FMRF-Like Peptide Neighboring gene C2H2-type domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans. Beets I, et al. Science, 2012 Oct 26. PMID 23112336
    2. The long and the short of it - a perspective on peptidergic regulation of circuits and behaviour. Jékely G, et al. J Exp Biol, 2018 Feb 8. PMID 29439060
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ntc-1 encodes a VP/OT-related peptide, nematocin, that signals through the NTR-1 receptor.[NTR-1]
      Title: Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein;Nematocin receptor 1
    NP_001360454.1
    • Confirmed by transcript evidence
    NP_493193.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12615921..12624241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373647.2 → NP_001360454.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WV28
      Conserved Domains (1) summary
      cd15196
      Location:53 → 361
      7tmA_Vasopressin_Oxytocin; vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_060792.2 → NP_493193.1  Nematocin receptor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493193.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02300
      Conserved Domains (1) summary
      pfam00001
      Location:61 → 340
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02300.1

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