ELM1 serine/threonine protein kinase ELM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ELM1
Gene description: serine/threonine protein kinase ELM1
Primary source: SGD:S000001531
Locus tag: YKL048C
See related: AllianceGenome:SGD:S000001531
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LDB9
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of protein autophosphorylation; protein localization to septin ring; and pseudohyphal growth. Acts upstream of or within maltose metabolic process. Located in cellular bud neck septin ring. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (347214..349136, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling.
Title: Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling.
The LKB1-like Kinase Elm1 Controls Septin Hourglass Assembly and Stability by Regulating Filament Pairing.
Title: The LKB1-like Kinase Elm1 Controls Septin Hourglass Assembly and Stability by Regulating Filament Pairing.
Findings suggest that Elm1 plays a key role in sensing bud emergence.
Title: Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1.
Dma1 and Dma2 control septin dynamics and the SPOC by promoting the efficient recruitment of Elm1 to the bud neck
Title: Budding yeast dma proteins control septin dynamics and the spindle position checkpoint by promoting the recruitment of the Elm1 kinase to the bud neck.
Hsl1p activation involves the phosphorylation of threonine 273, promoted by the septin-associated kinase Elm1p.
Title: The checkpoint kinase Hsl1p is activated by Elm1p-dependent phosphorylation.
Elm1 regulates the septin assembly-dependent cellular events by directly phosphorylating and activating the Gin4-dependent pathway
Title: Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast.
ELM1, and genes encoding related serine/threonine protein kinases, are required for regulation of multidrug resistance involving, at least in part, control of PDR5 transcription.
Title: ELM1 is required for multidrug resistance in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in budding cell bud growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maltose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to septin ring	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in pseudohyphal growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septin ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck	HDA more info	PubMed
located_in cellular bud neck septin ring	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck septin ring	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine protein kinase ELM1

NP_012876.1

EC 2.7.11.1

Serine/threonine protein kinase; regulates the orientation checkpoint, the morphogenesis checkpoint and the metabolic switch from fermentative to oxidative metabolism by phosphorylating the activation loop of Kin4p, Hsl1p and Snf1p respectively; cooperates with Hsl7p in recruiting Hsl1p to the septin ring, a prerequisite for subsequent recruitment, phosphorylation, and degradation of Swe1p; forms part of the bud neck ring; regulates cytokinesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

347214..349136 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179614.1 → NP_012876.1 TPA: serine/threonine protein kinase ELM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012876.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXN9, P32801

UniProtKB/TrEMBL

A0A8H4F8U2, A6ZZR8, B3LR41, B5VMA9, C7GP26, N1NZ87

Conserved Domains (1) summary

cl21453
Location:95 → 402

PKc_like; Protein Kinases, catalytic domain