ISA1 Fe-binding Fe/S cluster assembly protein ISA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: ISA1
Gene description: Fe-binding Fe/S cluster assembly protein ISA1
Primary source: SGD:S000003950
Locus tag: YLL027W
See related: AllianceGenome:SGD:S000003950
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables iron ion binding activity. Involved in biotin biosynthetic process; iron-sulfur cluster assembly; and protein maturation by [4Fe-4S] cluster transfer. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 5. Orthologous to human ISCA1 (iron-sulfur cluster assembly 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IDA Inferred from Direct Assay more info	PubMed
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	ISA Inferred from Sequence Alignment more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biotin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in biotin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in iron-sulfur cluster assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein maturation by [4Fe-4S] cluster transfer	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein maturation by iron-sulfur cluster transfer	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation by iron-sulfur cluster transfer	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_013073.1

Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins; human ISCA1 can complement isa1 null mutant

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