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    Park7 Parkinson disease (autosomal recessive, early onset) 7 [ Mus musculus (house mouse) ]

    Gene ID: 57320, updated on 9-Apr-2017
    Official Symbol
    Park7provided by MGI
    Official Full Name
    Parkinson disease (autosomal recessive, early onset) 7provided by MGI
    Primary source
    MGI:MGI:2135637
    See related
    Ensembl:ENSMUSG00000028964 Vega:OTTMUSG00000010158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dj1; DJ-1
    Orthologs
    Location:
    4; 4 E2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (150897133..150909921, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (150271242..150284030, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700045H11 gene Neighboring gene 40S ribosomal protein S15a-like Neighboring gene ERBB receptor feedback inhibitor 1 Neighboring gene tumor necrosis factor receptor superfamily, member 9 Neighboring gene predicted gene, 30120

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
    • Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
      Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    L-dopa decarboxylase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    cupric ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    cuprous ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    mercury ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity, acting on peroxide as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peroxiredoxin activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein deglycase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    superoxide dismutase copper chaperone activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    tyrosine 3-monooxygenase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-like protein conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to glyoxal IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to glyoxal ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detoxification of copper ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detoxification of copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    detoxification of mercury ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detoxification of mercury ion ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine uptake involved in synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enzyme active site formation via L-cysteine sulfinic acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutathione deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    glycolate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycolate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    glyoxal metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glyoxal metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    hydrogen peroxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hydrogen peroxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    lactate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane hyperpolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of TRAIL-activated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hydrogen peroxide-induced cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hydrogen peroxide-induced neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of hydrogen peroxide-induced neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative stress-induced cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative stress-induced neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ubiquitin-protein transferase activity IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-arginine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-cysteine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-lysine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of L-dopa biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of L-dopa decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NAD(P)H oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of acute inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of androgen receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial electron transport, NADH to ubiquinone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of oxidative phosphorylation uncoupler activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pyrroline-5-carboxylate reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of reactive oxygen species biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of superoxide dismutase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine 3-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein deglycation, glyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with mitochondrial respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    protein DJ-1
    Names
    RNA-binding protein regulatory subunit
    parkinson disease protein 7 homolog
    protein deglycase DJ-1
    NP_065594.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020569.3NP_065594.2  protein DJ-1

      See identical proteins and their annotated locations for NP_065594.2

      Status: VALIDATED

      Source sequence(s)
      AB015652, CA456587, CD776363
      Consensus CDS
      CCDS18975.1
      UniProtKB/Swiss-Prot
      Q99LX0
      Related
      ENSMUSP00000030805.7, OTTMUSP00000010787, ENSMUST00000030805.13, OTTMUST00000023609
      Conserved Domains (2) summary
      cd03135
      Location:6172
      GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
      TIGR01383
      Location:5184
      not_thiJ; DJ-1 family protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      150897133..150909921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187025.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      1202157..1214994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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