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    AIP aryl hydrocarbon receptor interacting protein [ Homo sapiens (human) ]

    Gene ID: 9049, updated on 12-Mar-2017
    Official Symbol
    AIPprovided by HGNC
    Official Full Name
    aryl hydrocarbon receptor interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:358
    See related
    Ensembl:ENSG00000110711 MIM:605555; Vega:OTTHUMG00000167674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARA9; XAP2; XAP-2; FKBP16; FKBP37; SMTPHN
    Summary
    The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
    Orthologs
    Location:
    11q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (67483029..67491108)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67250505..67258579)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4 Neighboring gene transmembrane protein 134 Neighboring gene microRNA 6752 Neighboring gene phosphatidylinositol transfer protein membrane associated 1 Neighboring gene cyclin dependent kinase 2 associated protein 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Aryl Hydrocarbon Receptor, organism-specific biosystem (from WikiPathways)
      Aryl Hydrocarbon Receptor, organism-specific biosystemThe Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or...
    • Aryl Hydrocarbon Receptor Pathway, organism-specific biosystem (from WikiPathways)
      Aryl Hydrocarbon Receptor Pathway, organism-specific biosystemThe aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic m...
    • Aryl hydrocarbon receptor signalling, organism-specific biosystem (from REACTOME)
      Aryl hydrocarbon receptor signalling, organism-specific biosystemThe aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that belongs to the basic helix-loop-helix/PER-ARNT-SIM family of DNA binding proteins and controls the expression of a ...
    • Biological oxidations, organism-specific biosystem (from REACTOME)
      Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
      Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GAF domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aryl hydrocarbon receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein maturation by protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein targeting to mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of nucleic acid-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein kinase A signaling IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    aryl hydrocarbon receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    AH receptor-interacting protein
    Names
    HBV X-associated protein 2
    immunophilin homolog ARA9
    NP_001289888.1
    NP_001289889.1
    NP_003968.2
    NP_003968.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008969.1 RefSeqGene

      Range
      4996..13075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_460

    mRNA and Protein(s)

    1. NM_001302959.1NP_001289888.1  AH receptor-interacting protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in place of the first exon in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      BQ054206, CN480874, U31913, U78521
      UniProtKB/Swiss-Prot
      O00170
      Conserved Domains (1) summary
      sd00006
      Location:124166
      TPR; TPR repeat [structural motif]
    2. NM_001302960.1NP_001289889.1  AH receptor-interacting protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction in the 3' end of the coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BQ420398, CN480874, HY065637, U31913, U78521
      UniProtKB/Swiss-Prot
      O00170
      Conserved Domains (1) summary
      cl19519
      Location:2990
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    3. NM_003977.3NP_003968.3  AH receptor-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_003968.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      CN480874, HY065637, U31913, U78521
      Consensus CDS
      CCDS8168.1
      UniProtKB/Swiss-Prot
      O00170
      UniProtKB/TrEMBL
      G9I2H4
      Related
      ENSP00000279146, OTTHUMP00000236412, ENST00000279146, OTTHUMT00000395516
      Conserved Domains (2) summary
      sd00006
      Location:183225
      TPR; TPR repeat [structural motif]
      cl19519
      Location:2990
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      67483029..67491108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      67133543..67141623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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