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    GPX2 glutathione peroxidase 2 [ Homo sapiens (human) ]

    Gene ID: 2877, updated on 3-Dec-2017
    Official Symbol
    GPX2provided by HGNC
    Official Full Name
    glutathione peroxidase 2provided by HGNC
    Primary source
    HGNC:HGNC:4554
    See related
    Ensembl:ENSG00000176153 MIM:138319; Vega:OTTHUMG00000171677
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPRP; GPx-2; GI-GPx; GPRP-2; GPx-GI; GSHPx-2; GSHPX-GI
    Summary
    The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in gall bladder (RPKM 164.4), stomach (RPKM 114.6) and 8 other tissues See more
    Orthologs
    Location:
    14q23.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (64939152..64942905, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65405870..65409623, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene CHURC1-FNTB readthrough Neighboring gene ribonuclease P RNA component H1, 2 pseudogene Neighboring gene churchill domain containing 1 Neighboring gene RAB15, member RAS oncogene family Neighboring gene uncharacterized LOC107984655 Neighboring gene farnesyltransferase, CAAX box, beta

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat GPX2 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
    tat HIV-1 Tat causes a greater than 50% decrease in intracellular reduced glutathione (GSH), leading to the extracellular appearance of acidic FGF-1, an effect that is partially mediated through modulation of GSH biosynthetic enzymes PubMed
    tat Expression of HIV-1 Tat in HeLa cells downregulates cytoplasmic glutathione peroxidase while upregulating phospholipid hydroperoxide glutathione peroxidase, thereby deregulating intracellular oxidant/antioxidant balance and amplifying UV sensitivity PubMed
    nucleocapsid gag Glutathione peroxidase 2 (GPX2) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    electron transfer activity TAS
    Traceable Author Statement
    more info
    PubMed 
    glutathione peroxidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidative stress TAS
    Traceable Author Statement
    more info
     
    electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    glutathione peroxidase 2
    Names
    gastrointestinal glutathione peroxidase
    glutathione peroxidase 2 (gastrointestinal)
    glutathione peroxidase-related protein 2
    NP_002074.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002083.3NP_002074.2  glutathione peroxidase 2

      See identical proteins and their annotated locations for NP_002074.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      BC022820, BG429974
      Consensus CDS
      CCDS41964.1
      UniProtKB/Swiss-Prot
      P18283
      Related
      ENSP00000374265.5, OTTHUMP00000246692, ENST00000389614.5, OTTHUMT00000414708
      Conserved Domains (1) summary
      cd00340
      Location:7182
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    RNA

    1. NR_046320.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK225871, BC022820, BG429974
      Related
      ENST00000553522.1, OTTHUMT00000414707
    2. NR_046321.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK225871, AL139022, BC022820, BF207526, BG429974
    3. NR_138078.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an additional internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA135289, BC022820, BF207526, BF759921, BG429974, BI015236

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      64939152..64942905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      65344036..65347793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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