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    GPX8 glutathione peroxidase 8 (putative) [ Homo sapiens (human) ]

    Gene ID: 493869, updated on 3-Sep-2017
    Official Symbol
    GPX8provided by HGNC
    Official Full Name
    glutathione peroxidase 8 (putative)provided by HGNC
    Primary source
    HGNC:HGNC:33100
    See related
    Ensembl:ENSG00000164294 MIM:617172; Vega:OTTHUMG00000162601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPx-8; UNQ847; EPLA847; GSHPx-8
    Orthologs
    Location:
    5q11.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (55160118..55167301)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54455984..54463129)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene granzyme A pseudogene 1 Neighboring gene granzyme A Neighboring gene cell division cycle 20B Neighboring gene microRNA 449a Neighboring gene microRNA 449b

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peroxidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidative stress TAS
    Traceable Author Statement
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    probable glutathione peroxidase 8
    NP_001008398.2
    NP_001293126.1
    NP_001293127.1
    NP_001293130.1
    XP_006714694.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008397.3NP_001008398.2  probable glutathione peroxidase 8 isoform a

      See identical proteins and their annotated locations for NP_001008398.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK074216, BM988796, BX537894, BX647770, CN390753
      Consensus CDS
      CCDS34156.1
      UniProtKB/Swiss-Prot
      Q8TED1
      Related
      ENSP00000423822.1, OTTHUMP00000222385, ENST00000503787.5, OTTHUMT00000369717
      Conserved Domains (1) summary
      TIGR02540
      Location:46198
      gpx7; putative glutathione peroxidase Gpx7
    2. NM_001306197.1NP_001293126.1  probable glutathione peroxidase 8 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' terminal exon, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK074216, AK298545, BM988796, BX537894, BX647770, CN390753
      Consensus CDS
      CCDS78009.1
      UniProtKB/Swiss-Prot
      Q8TED1
      UniProtKB/TrEMBL
      B4DPY0, E7ETY7
      Related
      ENSP00000427466.1, OTTHUMP00000222386, ENST00000515370.1, OTTHUMT00000369719
      Conserved Domains (1) summary
      cl00388
      Location:15147
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    3. NM_001306198.1NP_001293127.1  probable glutathione peroxidase 8 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK074216, AK307365, BM988796, BX537894, BX647770, CN390753
      Consensus CDS
      CCDS82997.1
      UniProtKB/Swiss-Prot
      Q8TED1
      UniProtKB/TrEMBL
      J3KNB5
      Related
      ENSP00000296734.6, OTTHUMP00000222387, ENST00000296734.6, OTTHUMT00000369720
      Conserved Domains (1) summary
      cl00388
      Location:4669
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    4. NM_001306201.1NP_001293130.1  probable glutathione peroxidase 8 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in both the 5' terminal exon and in an internal exon, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
      Source sequence(s)
      AK074216, BM988796, BX537894, BX647770, CN390753, DA660205
      UniProtKB/Swiss-Prot
      Q8TED1
      Conserved Domains (1) summary
      cl00388
      Location:14105
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RNA

    1. NR_131336.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) splices out an alternate segment in the 5' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK074216, BM988796, BX537894, BX647770, CN390753
      Related
      ENST00000506123.5
    2. NR_131337.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) splices out an alternate segment in the 5' terminal exon, and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK074216, BM835879, BM988796, BX537894, BX647770, CN390753
    3. NR_131338.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) splices out an alternate segment in the 5' terminal exon, and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK074216, BM988796, BX537894, BX647770, CN390753, HY174481
    4. NR_131340.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK074216, BG620710, BM988796, BX537894, BX647770, CN390753

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      55160118..55167301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714631.2XP_006714694.1  probable glutathione peroxidase 8 isoform X1

      Conserved Domains (1) summary
      TIGR02540
      Location:46199
      gpx7; putative glutathione peroxidase Gpx7

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      54459441..54466622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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