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    Gpnmb glycoprotein (transmembrane) nmb [ Mus musculus (house mouse) ]

    Gene ID: 93695, updated on 17-Sep-2017
    Official Symbol
    Gpnmbprovided by MGI
    Official Full Name
    glycoprotein (transmembrane) nmbprovided by MGI
    Primary source
    MGI:MGI:1934765
    See related
    Ensembl:ENSMUSG00000029816 Vega:OTTMUSG00000057401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ipd; Dchil; DC-HIL
    Orthologs
    Location:
    6 B2.3; 6 23.82 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (49036518..49058182)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (48986517..49008181)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930563H07 gene Neighboring gene seminal vesicle secretory protein 1 Neighboring gene amiloride binding protein 1 (amine oxidase, copper-containing) pseudogene Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene mitochondrial assembly of ribosomal large subunit 1 Neighboring gene predicted gene 7890

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    syndecan binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of tissue remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of tissue remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    transmembrane glycoprotein NMB
    Names
    dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand
    dendritic cell-associated transmembrane protein
    iris pigment dispersion
    osteoactivin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053110.4NP_444340.3  transmembrane glycoprotein NMB precursor

      See identical proteins and their annotated locations for NP_444340.3

      Status: VALIDATED

      Source sequence(s)
      AC153620, AK171465, AK171517, BY205729
      Consensus CDS
      CCDS20122.1
      UniProtKB/Swiss-Prot
      Q99P91
      Related
      ENSMUSP00000031840.7, OTTMUSP00000073829, ENSMUST00000031840.9, OTTMUST00000141205
      Conserved Domains (1) summary
      cd00146
      Location:256316
      PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      49036518..49058182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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