Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ets1 E26 avian leukemia oncogene 1, 5' domain [ Mus musculus (house mouse) ]

    Gene ID: 23871, updated on 31-Dec-2017
    Official Symbol
    Ets1provided by MGI
    Official Full Name
    E26 avian leukemia oncogene 1, 5' domainprovided by MGI
    Primary source
    MGI:MGI:95455
    See related
    Ensembl:ENSMUSG00000032035 Vega:OTTMUSG00000044662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    vs; Tpl1; Ets-1; AI196000; AI448617; D230050P06
    Expression
    Biased expression in thymus adult (RPKM 75.8), spleen adult (RPKM 42.2) and 13 other tissues See more
    Orthologs
    Location:
    9 A4; 9 17.97 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (32636210..32757820)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (32503627..32565405)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31871 Neighboring gene predicted gene, 31928 Neighboring gene predicted gene 3331 Neighboring gene predicted gene 27162

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Targeted (4)  1 citation
    • Chemically induced (ENU) (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC18571, MGC130355

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific double-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    PML body organization ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular component movement ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    pri-miRNA transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
     
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    protein C-ets-1
    Names
    avian erythroblastosis virus E26 oncogene 1
    p54
    tumor progression locus 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038642.1NP_001033731.1  protein C-ets-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter buy has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC139108, AY035702, BB621050
      Consensus CDS
      CCDS40572.1
      UniProtKB/TrEMBL
      E9PWI8, Q8K3Q9
      Related
      ENSMUSP00000051303.6, OTTMUSP00000065698, ENSMUST00000050797.13, OTTMUST00000117492
      Conserved Domains (2) summary
      cd08542
      Location:51138
      SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
      smart00413
      Location:247331
      ETS; erythroblast transformation specific domain
    2. NM_011808.2NP_035938.2  protein C-ets-1 isoform 1

      See identical proteins and their annotated locations for NP_035938.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AC139108, AK076233, BB621050, CD550586
      Consensus CDS
      CCDS22954.1
      UniProtKB/Swiss-Prot
      P27577
      UniProtKB/TrEMBL
      Q540Q5, Q8BVW8
      Related
      ENSMUSP00000034534.5, OTTMUSP00000065695, ENSMUST00000034534.12, OTTMUST00000117489
      Conserved Domains (2) summary
      cd08542
      Location:51138
      SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
      smart00413
      Location:334418
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      32636210..32757820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510269.1XP_006510332.1  protein C-ets-1 isoform X1

      Conserved Domains (2) summary
      cd08542
      Location:95182
      SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
      smart00413
      Location:378462
      ETS; erythroblast transformation specific domain
    Support Center