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    Pawr PRKC, apoptosis, WT1, regulator [ Mus musculus (house mouse) ]

    Gene ID: 114774, updated on 22-Nov-2017
    Official Symbol
    Pawrprovided by MGI
    Official Full Name
    PRKC, apoptosis, WT1, regulatorprovided by MGI
    Primary source
    MGI:MGI:2149961
    See related
    Ensembl:ENSMUSG00000035873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAR4; Par-4; 2310001G03Rik
    Orthologs
    Location:
    10; 10 D1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (108332189..108414391)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (107769245..107851447)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40754 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 12A Neighboring gene predicted gene, 40755 Neighboring gene uncharacterized LOC105245279 Neighboring gene predicted gene, 36283 Neighboring gene predicted gene, 36440 Neighboring gene synaptotagmin I

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    leucine zipper domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    calcium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    detection of mechanical stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    detection of temperature stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-2 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial to mesenchymal transition NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of action potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of amyloid precursor protein biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hindgut contraction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hydrogen peroxide-mediated programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neutrophil extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of relaxation of smooth muscle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    PRKC apoptosis WT1 regulator protein
    Names
    prostate apoptosis response 4 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054056.2NP_473397.1  PRKC apoptosis WT1 regulator protein

      See identical proteins and their annotated locations for NP_473397.1

      Status: VALIDATED

      Source sequence(s)
      AW123400, DQ363525, DV057979
      Consensus CDS
      CCDS36053.1
      UniProtKB/Swiss-Prot
      Q925B0
      Related
      ENSMUSP00000092951.3, ENSMUST00000095313.4
      Conserved Domains (1) summary
      cl00459
      Location:255331
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      108332189..108414391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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