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    Mapt microtubule-associated protein tau [ Mus musculus (house mouse) ]

    Gene ID: 17762, updated on 18-Jul-2017
    Official Symbol
    Maptprovided by MGI
    Official Full Name
    microtubule-associated protein tauprovided by MGI
    Primary source
    MGI:MGI:97180
    See related
    Ensembl:ENSMUSG00000018411 Vega:OTTMUSG00000003153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tau; Mtapt; AI413597; AW045860
    Orthologs
    Location:
    11 67.79 cM; 11 E1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (104231273..104332090)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (104092750..104193410)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene corticotropin releasing hormone receptor 1 Neighboring gene predicted gene, 35469 Neighboring gene signal peptide peptidase 2C Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene cell division cycle 27 Neighboring gene myosin, light polypeptide 4

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipoprotein particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule lateral binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor agonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adult walking behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    axo-dendritic transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intracellular distribution of mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of establishment of protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of long term synaptic depression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to synapse ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of catabolic autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    response to nutrient ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    supramolecular fiber organization ISO
    Inferred from Sequence Orthology
    more info
     
    synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axolemma ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell body ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    main axon ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with membrane ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    neurofibrillary tangle ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density of dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    somatodendritic compartment ISO
    Inferred from Sequence Orthology
    more info
     
    tubulin complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    microtubule-associated protein tau
    Names
    PHF-tau
    neurofibrillary tangle protein
    paired helical filament-tau

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038609.2NP_001033698.1  microtubule-associated protein tau isoform a

      See identical proteins and their annotated locations for NP_001033698.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK147636, BM950831, BY249380, CA450773, M18775
      Consensus CDS
      CCDS25527.1
      UniProtKB/Swiss-Prot
      P10637
      UniProtKB/TrEMBL
      Q3UH19
      Related
      ENSMUSP00000097919.4, OTTMUSP00000003083, ENSMUST00000100347.10, OTTMUST00000006516
      Conserved Domains (1) summary
      pfam00418
      Location:264293
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    2. NM_001285454.1NP_001272383.1  microtubule-associated protein tau isoform c

      See identical proteins and their annotated locations for NP_001272383.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple coding region differences and differs in the 3' UTR, compared to variant 1. The resulting isoform (c) lacks two internal segments and has a longer and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK147636, CA450773, M18776, W18770
      UniProtKB/Swiss-Prot
      P10637
      UniProtKB/TrEMBL
      Q3UH19
      Conserved Domains (1) summary
      pfam00418
      Location:206235
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    3. NM_001285455.1NP_001272384.1  microtubule-associated protein tau isoform d

      See identical proteins and their annotated locations for NP_001272384.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three consecutive exons in the 5' coding region, compared to variant 1. The resulting isoform (d) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AL593843, AL596383
      UniProtKB/Swiss-Prot
      P10637
      Conserved Domains (1) summary
      pfam00418
      Location:184213
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    4. NM_001285456.1NP_001272385.1  microtubule-associated protein tau isoform e

      See identical proteins and their annotated locations for NP_001272385.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two consecutive exons in the 5' coding region and an exon in the 3' coding region, compared to variant 1. The resulting isoform (e) lacks two internal segments, compared to isoform a.
      Source sequence(s)
      AK147636, BM950831, CA450773, M18775, W18770
      UniProtKB/Swiss-Prot
      P10637
      UniProtKB/TrEMBL
      Q3UH19
      Conserved Domains (1) summary
      pfam00418
      Location:206235
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    5. NM_010838.4NP_034968.3  microtubule-associated protein tau isoform b

      See identical proteins and their annotated locations for NP_034968.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive exons in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AK078167, AK147636, BM950831, BY249380, CA450773, M18775
      Consensus CDS
      CCDS25528.1
      UniProtKB/Swiss-Prot
      P10637
      UniProtKB/TrEMBL
      Q3UH19, Q547J4, Q8C5K4
      Related
      ENSMUSP00000102605.3, OTTMUSP00000003078, ENSMUST00000106992.9, OTTMUST00000006510
      Conserved Domains (1) summary
      pfam00418
      Location:206235
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      104231273..104332090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532410.3XP_006532473.1  microtubule-associated protein tau isoform X5

      Related
      ENSMUSP00000102602.1, OTTMUSP00000003080, ENSMUST00000106989.2, OTTMUST00000006512
      Conserved Domains (2) summary
      pfam00418
      Location:601630
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl21589
      Location:376546
      Relaxase; Relaxase/Mobilization nuclease domain
    2. XM_006532407.3XP_006532470.1  microtubule-associated protein tau isoform X2

      See identical proteins and their annotated locations for XP_006532470.1

      Conserved Domains (1) summary
      pfam00418
      Location:235264
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    3. XM_006532408.3XP_006532471.1  microtubule-associated protein tau isoform X3

      Conserved Domains (1) summary
      pfam00418
      Location:264293
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    4. XM_006532409.2XP_006532472.1  microtubule-associated protein tau isoform X4

      See identical proteins and their annotated locations for XP_006532472.1

      Conserved Domains (1) summary
      pfam00418
      Location:235264
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    5. XM_017314315.1XP_017169804.1  microtubule-associated protein tau isoform X1

    Reference GRCm38.p4 129X1/SvJ

    Genomic

    1. NT_039525.1 Reference GRCm38.p4 129X1/SvJ

      Range
      30428..133199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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