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    Me1 malic enzyme 1, NADP(+)-dependent, cytosolic [ Mus musculus (house mouse) ]

    Gene ID: 17436, updated on 8-Oct-2017
    Official Symbol
    Me1provided by MGI
    Official Full Name
    malic enzyme 1, NADP(+)-dependent, cytosolicprovided by MGI
    Primary source
    MGI:MGI:97043
    See related
    Ensembl:ENSMUSG00000032418 Vega:OTTMUSG00000045046
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mod1; Mdh-1; Mod-1; D9Ertd267e
    Orthologs
    Location:
    9 E3.1; 9 46.58 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (86581363..86695914, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (86474970..86589947, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene dopey family member 1 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene RIKEN cDNA A330041J22 gene Neighboring gene protease, serine 35 Neighboring gene synaptosomal-associated protein 91

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC91072

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    NADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    malate dehydrogenase (decarboxylating) (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    malate dehydrogenase (decarboxylating) (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    malate dehydrogenase (decarboxylating) (NADP+) activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    malate dehydrogenase (decarboxylating) (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    malate dehydrogenase (decarboxylating) (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    malic enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    malic enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxaloacetate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    malate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    malate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    protein tetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    NADP-dependent malic enzyme
    Names
    NADP-ME
    malic enzyme, supernatant
    NP_001185862.1
    NP_032641.2
    XP_011240968.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198933.1NP_001185862.1  NADP-dependent malic enzyme isoform 2

      See identical proteins and their annotated locations for NP_001185862.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon at its 5' UTR and 5' coding region, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK077968, AK163403, AV363687
      Consensus CDS
      CCDS81047.1
      UniProtKB/Swiss-Prot
      P06801
      UniProtKB/TrEMBL
      Q3TQP6
      Related
      ENSMUSP00000140887.1, OTTMUSP00000066083, ENSMUST00000185374.1, OTTMUST00000118381
      Conserved Domains (3) summary
      cd05312
      Location:250527
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:7531
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:59240
      malic; Malic enzyme, N-terminal domain
    2. NM_008615.2NP_032641.2  NADP-dependent malic enzyme isoform 1

      See identical proteins and their annotated locations for NP_032641.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK077968, AV363687, CJ070715
      Consensus CDS
      CCDS23383.1
      UniProtKB/Swiss-Prot
      P06801
      Related
      ENSMUSP00000034989.8, OTTMUSP00000066082, ENSMUST00000034989.14, OTTMUST00000118380
      Conserved Domains (3) summary
      cd05312
      Location:270547
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:2551
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:79260
      malic; Malic enzyme, N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      86581363..86695914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242666.2XP_011240968.1  NADP-dependent malic enzyme isoform X1

      Conserved Domains (3) summary
      cd05312
      Location:195472
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      COG0281
      Location:5474
      SfcA; Malic enzyme [Energy production and conversion]
      pfam00390
      Location:4185
      malic; Malic enzyme, N-terminal domain
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