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    Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A [ Mus musculus (house mouse) ]

    Gene ID: 20356, updated on 28-May-2017
    Official Symbol
    Sema5aprovided by MGI
    Official Full Name
    sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Aprovided by MGI
    Primary source
    MGI:MGI:107556
    See related
    Ensembl:ENSMUSG00000022231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    semF; Semaf; AI464145; 5930434A13; 9130201M22Rik
    Orthologs
    Location:
    15 B3.1; 15 13.02 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (32244742..32696341)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (32174568..32626096)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32499 Neighboring gene taste receptor, type 2, member 119 Neighboring gene small nucleolar RNA, C/D box 123 Neighboring gene small nucleolar RNA host gene 18 Neighboring gene predicted gene, 32562 Neighboring gene predicted gene, 41289 Neighboring gene predicted gene, 32618

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    axon guidance receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chondroitin sulfate proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    heparan sulfate proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    neuropilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    semaphorin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    syndecan binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    axon extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonal fasciculation ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    detection of light stimulus involved in visual perception IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    diencephalon development ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of axon extension involved in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron projection guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of axon extension involved in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catenin import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of extracellular matrix disassembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    semaphorin-plexin signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal clustering IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal clustering ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    semaphorin-5A
    Names
    M-Sema D
    sema F
    semaphorin F

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009154.2NP_033180.2  semaphorin-5A precursor

      See identical proteins and their annotated locations for NP_033180.2

      Status: VALIDATED

      Source sequence(s)
      AC110236, AK141612, BB643469
      Consensus CDS
      CCDS37055.1
      UniProtKB/TrEMBL
      Q3UPZ0
      Related
      ENSMUSP00000069024.6, ENSMUST00000067458.6
      Conserved Domains (3) summary
      cd11263
      Location:50485
      Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
      smart00209
      Location:598651
      TSP1; Thrombospondin type 1 repeats
      pfam01437
      Location:486533
      PSI; Plexin repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      32244742..32696341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245340.1XP_011243642.1  semaphorin-5A isoform X1

      See identical proteins and their annotated locations for XP_011243642.1

      UniProtKB/TrEMBL
      Q3UPZ0
      Conserved Domains (3) summary
      cd11263
      Location:50485
      Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
      smart00209
      Location:598651
      TSP1; Thrombospondin type 1 repeats
      pfam01437
      Location:486533
      PSI; Plexin repeat
    2. XM_006520043.3XP_006520106.1  semaphorin-5A isoform X1

      See identical proteins and their annotated locations for XP_006520106.1

      UniProtKB/TrEMBL
      Q3UPZ0
      Conserved Domains (3) summary
      cd11263
      Location:50485
      Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
      smart00209
      Location:598651
      TSP1; Thrombospondin type 1 repeats
      pfam01437
      Location:486533
      PSI; Plexin repeat
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