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    METTL7A methyltransferase like 7A [ Homo sapiens (human) ]

    Gene ID: 25840, updated on 9-Jul-2017
    Official Symbol
    METTL7Aprovided by HGNC
    Official Full Name
    methyltransferase like 7Aprovided by HGNC
    Primary source
    HGNC:HGNC:24550
    See related
    Ensembl:ENSG00000185432 Vega:OTTHUMG00000169484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AAM-B
    Orthologs
    Location:
    12q13.12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (50923811..50932517)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51317780..51326300)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 519, pseudogene Neighboring gene transmembrane protease, serine 12 Neighboring gene HIG1 hypoxia inducible domain family member 1C Neighboring gene solute carrier family 11 member 2 Neighboring gene RNA, U7 small nuclear 39 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp586A0522

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    lipid droplet IDA
    Inferred from Direct Assay
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    tertiary granule lumen TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    methyltransferase-like protein 7A
    Names
    protein AAM-B
    NP_054752.3
    XP_006719395.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014033.3NP_054752.3  methyltransferase-like protein 7A precursor

      See identical proteins and their annotated locations for NP_054752.3

      Status: VALIDATED

      Source sequence(s)
      AC008121, AY358797, BM805242
      Consensus CDS
      CCDS8804.1
      UniProtKB/Swiss-Prot
      Q9H8H3
      UniProtKB/TrEMBL
      A0A024R118
      Related
      ENSP00000331787.4, ENST00000332160.4
      Conserved Domains (1) summary
      pfam08241
      Location:75172
      Methyltransf_11; Methyltransferase domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      50923811..50932517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006719332.1XP_006719395.1  methyltransferase-like protein 7A isoform X1

      See identical proteins and their annotated locations for XP_006719395.1

      UniProtKB/Swiss-Prot
      Q9H8H3
      UniProtKB/TrEMBL
      A0A024R118
      Related
      ENSP00000448785.1, OTTHUMP00000241251, ENST00000548553.1, OTTHUMT00000404294
      Conserved Domains (1) summary
      pfam08241
      Location:75172
      Methyltransf_11; Methyltransferase domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      51284850..51292617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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